A5015685758- Fungal Infections and Studies
- Reproductive System and Pregnancy
- Cervical Cancer and HPV Research
- Antifungal resistance and susceptibility
- Head and Neck Cancer Studies
- Cancer-related Molecular Pathways
- Phytochemicals and Antioxidant Activities
- Phytochemistry Medicinal Plant Applications
- Natural product bioactivities and synthesis
- Tannin, Tannase and Anticancer Activities
- Nail Diseases and Treatments
- Essential Oils and Antimicrobial Activity
- Immunotherapy and Immune Responses
- Plant-Derived Bioactive Compounds
- Women's cancer prevention and management
- Phytochemical compounds biological activities
- Nanoplatforms for cancer theranostics
- Oral and Maxillofacial Pathology
- SARS-CoV-2 and COVID-19 Research
- Endometriosis Research and Treatment
- Genomics, phytochemicals, and oxidative stress
- Ocular Surface and Contact Lens
- Traditional and Medicinal Uses of Annonaceae
- Histone Deacetylase Inhibitors Research
- Renal Transplantation Outcomes and Treatments
Universidade Estadual Paulista (Unesp)
2015-2024
Centro Universitário de Araraquara
2005-2023
Universidade de São Paulo
2003-2022
Fundação Araucária
2021
Universidade Federal de Pernambuco
2018
Pathways Behavioral Services
2018
Ospedale Policlinico San Martino
2015
Hospital Geral de Fortaleza
2008-2014
Central Institute of Medicinal and Aromatic Plants
2010
Council of Scientific and Industrial Research
2010
Human papillomavirus (HPV) is believed to promote the oncogenic process, and correlation between viral oncoproteins dysfunction of p16 INK4A tumor suppressor protein in oral lesions controversial. To test hypothesis that anogenital HPV types participate disruption regulation lesions, we analyzed 46 biopsy specimens for presence 6/11 16/18 by situ hybridization (ISH) expression immunohistochemistry (IHC). Eighteen (39%) were HPV-positive 28 (61%) HPV-negative. DNA was found 5 (11%) 13 (28%)...
Paracoccidioides brasiliensis yeast cells can enter mammalian and may manipulate the host cell environment to favour their own growth survival. Moreover, fibronectin several other extracellular matrix proteins are recognized by various components of extracts. The present study was designed isolate characterize a fibronectin-binding protein from P. brasiliensis. We also compared strain 18, tested before (Pb18a) after (Pb18b) animal passage, in relation its adhesion invasion processes....
Considering that downregulation of HLA expression could represent a potential mechanism for breast carcinogenesis and metastasis, the aim present study was to use immunohistochemical methods analyze HLA-Ia, HLA-DR, HLA-DQ, HLA-E, HLA-G in invasive ductal carcinoma (IDC) relate this profile anatomopathological parameters. Fifty-two IDC from biopsies were stratified according histological differentiation (well, moderately, poorly differentiated) presence metastases axillary lymph nodes. The...
The effect of replacing corn with low-tannin sorghum on broiler performance, carcass yield, integrity mucosa small intestine segments, and activity membrane enzymes the jejunum is investigated. A total 594 male Cobb-500 chicks were randomly assigned to 3 dietary treatments: 100% (control), 50% replacement (low sorghum), (high sorghum). Body weight gain, feed consumption, conversion, yield determined at 7, 21, 42 d, segments collected. Feed conversion gain impaired d in broilers fed...
As the mechanisms leading to persistence of hepatitis B virus (HBV) infection are poorly understood and as histocompatibility leucocyte antigen (HLA)-G is well described a tolerogenic molecule, we evaluated HLA-G expression in 74 specimens HBV liver biopsies 10 obtained from previously healthy cadaver donors. were reviewed classified by METAVIR score, was assessed immunohistochemistry. No observed control hepatocytes. In contrast, 57 (77%) showed soluble membrane-bound hepatocytes, biliary...
HLA-G and HLA-E are two nonclassical class I molecules, which have been well recognized as modulators of innate adaptive immune responses, the expression these molecules in virus infected cells has associated with subversion response.In this study we performed a cross-sectional study, systematically comparing benign, pre-malignant malignant laryngeal lesions, correlating demographic clinical variables presence high-risk low-risk HPV types.Laryngeal lesions were collected from 109 patients...
Considering the reported activity of carvone in literature, this study aimed to evaluate antimicrobial, cytotoxic and chemopreventive activities (+)- (-)-carvone, (-)- hydroxydihydrocarvone α,β-epoxycarvone. (+)-Hydroxydihydrocarvone (HC+), (-)-hydroxydihydrocarvone (HC-) α,β-epoxycarvone (EP) were obtained by synthesis using (+)-carvone (C+) or (-)-carvone (C-) as precursors. The antifungal (MIC MFC) evaluated against Candida parapsilosis, C. tropicalis, krusei albicans antibacterial MBC)...
Gallic acid (3,4,5-trihydroxybenzoic acid), found in many plants either free-form or part of tannins, is known to possess anti-microbial, antioxidant and cytotoxic properties. NFκB regulates the expression several genes involved carcinogenesis. These include anti-apoptotic, cytokines cell cycle-regulatory genes. It well established that transcriptional factor deregulated forms cancer. Thus, agents can suppress activation have potential suppressing In present investigation, gallic was...
Methotrexate (MTX) is an immunosuppressive drug for systemic use in the treatment of skin diseases, however, MTX presents a number side effects, such as hepatotoxicity. To overcome this limitation, study developed delivery surfactant systems, microemulsion (ME) and liquid crystalline system (LCS), consisting glycol copolymer-based silicone fluid (SFGC) oil phase, polyether functional siloxane (PFS) surfactant, carbomer homopolymer type A (C971) dispersion at 0.5% (wt/wt) aqueous phase....
There have been few studies on the pharmacological properties of Rhamnus sphaerosperma var. pubescens , a native Brazilian species popularly known as “fruto‐de‐pombo.” The aim this study was to investigate scavenging capacity emodin, physcion, and ethanolic crude extract against reactive oxygen nitrogen species, well their role plausible mechanisms in prompting cell death changes AKT phosphorylation after cervical (SiHa C33A) oral (HSC‐3) squamous carcinoma treatments. Emodin shown be best...
Human leukocyte antigen-G (HLA-G) is a non-classical major histocompatibility complex class Ib molecule that acts as specific immunosuppressor. Some studies have demonstrated human papillomavirus (HPV) seems to be involved in lower or absent HLA-G expression, particularly cervical cancer. In this study, we performed cross-sectional systematically comparing the qualitative expression of HLA-G5 isoform invasive carcinoma (ICC), stratifying patients according presence [ICC with metastasis...
HLA-G is a nonclassical major histocompatibility complex molecule that has well-recognized immunomodulatory properties. The expression of in tumor cells been considered to be detrimental, permitting spreading and decreased survival. We evaluated the histologically normal thyroid tissue, goiter, benign malignant tumors, studied relationship between patient clinical variables.The immunohistochemistry was performed on 72 specimens papillary carcinoma (PTC), 19 follicular carcinomas (FTC), 22...
Photodynamic therapy (PDT) has proven to be a promising alternative current cancer treatments, especially if combined with conventional approaches. The technique is based on the administration of non-toxic photosensitizing agent patient subsequent localized exposure light source specific wavelength, resulting in cytotoxic response oxidative damage. present study intended evaluate vitro type induced death and genotoxic mutagenic effects PDT alone associated cisplatin.We used cell lines SiHa...
Aim: This study aimed to evaluate the activity of 2'-hydroxychalcone-loaded in nanoemulsion (NLS + 2'chalc), cytotoxic effect and toxicity against Paracoccidioides brasiliensis lutzii using a zebrafish model. Materials & methods: Preparation physical-chemical characterization (NLS) NLS 2'chalc were performed. MIC minimum fungicide concentration, cytotoxicity also evaluated Danio rerio Results: showed fungicidal spp. without MRC5 HepG2 lines. It had high selectivity index values no model...