A5059361037- Inflammatory Bowel Disease
- Microscopic Colitis
- COVID-19 and healthcare impacts
- Liver Diseases and Immunity
- Eosinophilic Esophagitis
- Diet and metabolism studies
- Biosimilars and Bioanalytical Methods
- Immunodeficiency and Autoimmune Disorders
- Adolescent and Pediatric Healthcare
- Gastrointestinal disorders and treatments
- Diet, Metabolism, and Disease
- Diverticular Disease and Complications
- COVID-19 Clinical Research Studies
- Esophageal and GI Pathology
- Trauma and Emergency Care Studies
- Celiac Disease Research and Management
- Wastewater Treatment and Reuse
- SARS-CoV-2 and COVID-19 Research
- Bayesian Methods and Mixture Models
- Liver Disease Diagnosis and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Tuberculosis Research and Epidemiology
- Diagnosis and treatment of tuberculosis
- Digestive system and related health
- Systemic Sclerosis and Related Diseases
Universidade de São Paulo
1982-2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2019-2024
Universidade Brasil
2021
Universidade do Estado do Rio de Janeiro
2013
Abstract Background Inflammatory bowel disease (IBD) patients often experience extraintestinal manifestations, which significantly impact their quality of life, contribute to disability, and impose substantial costs on healthcare systems. Osteoarticular manifestations are the most common type EIMs. Fibromyalgia (FM), second rheumatic disease, affects an estimated 2% 8% global population, with a higher prevalence among females. FM is characterized by widespread pain, frequently accompanied...
To assess the real-life, long-term effectiveness and safety of tofacitinib in a large cohort patients with refractory or difficult-to-treat ulcerative colitis (UC). This multicenter, retrospective, observational study included moderately to severely active UC who received for at least 8 weeks. Clinical remission response, endoscopic response remission, biochemical steroid-free clinical primary secondary loss drug discontinuation, need dose optimization, colectomy, adverse events were...
Therapeutic drug monitoring (TDM) during induction therapy with anti-tumor necrosis factor drugs has emerged as a strategy to optimize response these biologics and avoid undesired outcomes related inadequate exposure. This study aimed describe clinical, biological, endoscopic remission rates at six months in Brazilian inflammatory bowel disease (IBD) patients following proactive TDM algorithm guided by IFX trough levels (ITL) antibodies (ATI) induction, week six. A total of 111 IBD were...
In this paper, we present conditions on the likelihood function and prior distribution which permit us to assess effect of sample posterior distribution. Our work is inspired by Whitt (1979) J. Amer. Statist. Assoc. 74, based notions multivariate totally positive (strongly) mul-tivariate reverse rule functions introduced studied Karlin Rinott (1980a, b)
Patients with inflammatory bowel disease (IBD) are under increased risk of colonic dysplasia and neoplasia, approximately, 8 years after diagnosis.1 The development techniques that improve the diagnostic ability to detect those dysplasias has scientific, economic practical impact. NBI (narrow band image) been described as a valuable method comparable chromoendoscopy for detection many cancers upper digestive respiratory systems.2 two were compared in this study patients IBD at least from...
The excessive fat intake generally might induce obesity and metabolic disturbances. Thus, the goal of study was to assess role high-fat diets containing soybean or canola oil on intra-abdominal adiposity pancreatic morphology function young rats. After weaning, rats were fed with a control diet (7S) (19S) (19C) until they 60 days old, when sacrificed. Food (g/day), body mass length, retroperitoneal epididymal mass, HOMA-IR, HOMA-β area islets assessed. results considered different...
Abstract Background The management of inflammatory bowel disease (IBD) in the setting liver transplantation (LT) is a significant challenge. Previous data have described conflicting results on incidence relapses, risk colectomy and post-transplant prognosis. In addition, there no guidelines to recommend specific immunosuppressive regimens this scenario. Our aim describe IBD course cohort transplanted patients Latin America. Methods Medical records from two quaternary centers were reviewed...
Crystal-induced colitis, a rare complication of sevelamer therapy in Chronic Kidney Disease (CKD) patients, presents diagnostic challenges. We report case 39-year-old man with severe lower gastrointestinal bleeding attributed to sevelamer-induced colonic ulcers. Despite initial suspicion Crohn's disease, histopathological analysis revealed crystalline material suggestive sevelamer-associated colitis. Discontinuation led the cessation and stabilization patient's condition. This highlights...
Despite adequate treatment, a subgroup of patients with inflammatory bowel disease (IBD), including Crohn`s and ulcerative colitis, have persistent gastrointestinal symptoms that are not always related to mucosal damage. Recently, two autoantibodies, anti-CdtB anti-vinculin, were validated as post-infectious IBS (PI-IBS) markers, however there is limited evidence its diagnostic role in IBD population.
Inflammatory bowel diseases (IBD), comprising Crohn's disease and ulcerative colitis, are chronic inflammatory of the gastrointestinal tract that often have their onset among adolescents young adults (AYA). IBD characterized by episodes active interspersed with periods remission, its activity is inversely correlated health-related quality life (HRQL).This study aimed to determine whether AYA in remission or low would exhibit HRQL similar age-matched healthy individuals, demographic factors...
<b><i>Introduction:</i></b> The coronavirus disease 2019 (COVID-19) pandemic has increased concern regarding SARS-CoV-2 infection in inflammatory bowel (IBD) patients, especially those on immunosuppressive therapies or with active disease. There are limited reports describing the clinical features of COVID-19 an IBD population, and impact immunosuppression severity remains unclear. <b><i>Case Report:</i></b> A 33-year-old female patient a long...
Amyloidosis is a condition related to the extracellular deposition of abnormal fibrillar proteins. Gastric involvement may present as systemic or localized form disease. The endoscopic presentation can vary from nodular, ulcerated, infiltrative lesions. Clinical manifestations are nonspecific, including hyporexia, nausea, vomiting, weight loss, epigastralgia, and abdominal discomfort. Thus, amyloidosis clinically endoscopically mimic other diseases, such neoplasms, syphilis, tuberculosis,...
Abstract Background Despite adequate treatment, a subgroup of patients with inflammatory bowel disease (IBD), including Crohn's and ulcerative colitis, have persistent gastrointestinal symptoms that are not always related to mucosal damage. Recently, two autoantibodies, anti-CdtB anti-vinculin, were validated as post-infectious IBS (PI-IBS) markers, however there is limited evidence its diagnostic role in IBD population. Methods Patients more than 3 movements/day indication colonoscopy...
Crohn’s disease can occur throughout the entire gastrointestinal tract, often discontinuously, with ileum and colon being most common site. However, CD may involve any region of small bowel (SB) other than isolated SB present a diagnostic challenge. Double Balloon Enteroscopy (DBE) is an endoscopic modality for children that allow therapeutic procedures disease. Our aim was to evaluate by DBE in refractory treatment Between 2007 2010, 20 paediatric patients (age 2–17 years) diagnosis, were...
Abstract Background IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), are chronic recurrent inflammatory diseases of the gastrointestinal tract, most often diagnosed in adolescence young adulthood. Extra-intestinal manifestation (EIM) may be present initially up 50% or before IBD is diagnosed. its complications associated with morbidity has considerable impact upon patients’ health-related quality life (HRQoL). HRQoL an essential complement to examination clinical symptoms...