A5061587246- Reproductive System and Pregnancy
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Reproductive Physiology in Livestock
- Cervical Cancer and HPV Research
- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- T-cell and Retrovirus Studies
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Trypanosoma species research and implications
- Pancreatic function and diabetes
- Endometriosis Research and Treatment
- Urticaria and Related Conditions
- Cytomegalovirus and herpesvirus research
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Research on Leishmaniasis Studies
- Multiple Sclerosis Research Studies
- Reproductive Biology and Fertility
- Rheumatoid Arthritis Research and Therapies
- HIV Research and Treatment
- MicroRNA in disease regulation
Universidade de São Paulo
2016-2025
Clinics Hospital of Ribeirão Preto
2010-2025
Universidade de Ribeirão Preto
2014-2023
Theories and Approaches of Genomic Complexity
2023
Inserm
2023
Aix-Marseille Université
2023
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
1997-2023
Instituto do Coração
2023
Hospital do Coração
2023
Universidade Federal do Rio Grande do Norte
2023
HLA-G molecule has well-recognized tolerogenic properties, and the encoding gene shows lower frequency of polymorphism at coding region but higher variability regulatory 5’ 3’ untranslated (3’UTR) regions. At least three 3’UTR polymorphic sites have been associated with mRNA regulation, including 14 base pair (14bp) Insertion/Deletion, +3142C-G +3187A-G. We studied association (sequencing analysis, encompassing 14bp Ins-Del/+3003T-C/+3010C-G/+3027C-A/+3035C-T/+3142C-G/+3187A-G/+3196C-G...
Recent findings provide evidence of inflammasome critical role in the predisposition to autoimmune disorders. The involvement pathogenesis systemic lupus erythematosus (SLE) has been hypothesized even if no significant association within genes mutations or polymorphisms and reported yet. We analyzed 14 single nucleotide (SNPs) 7 (NLRP1, NLRP3, NLRC4, AIM2, CARD8, CASP1, IL1B) 144 patients affected by 158 healthy controls from Southern Brazilian (state São Paulo) with aim disclosing possible...
HLA-G molecule plays an important role on immune response regulation and has been implicated the inhibition of T natural killer cell cytolytic function allogeneic T-cell proliferation. Due to its immune-modulator properties, gene expression associated with outcome allograft autoimmune, infectious, malignant disorders. Several lines evidence indicate that polymorphisms at 5'-upstream regulatory region (5' URR) 3'-untranslated (3' UTR) may influence levels. Because Brazilians represent one...
Abstract Background Regardless the regulatory function of microRNAs (miRNA), their differential expression pattern has been used to define miRNA signatures and disclose disease biomarkers. To address question whether patients presenting different types diabetes mellitus could be distinguished on basis mRNA profiling, we obtained peripheral blood mononuclear cell (PBMC) RNAs from 7 type 1 (T1D), 2 (T2D), 6 gestational (GDM) patients, which were hybridized Agilent microarrays. Data...
Until recently, neuromyelitis optica (NMO) was considered to be a sub-type of multiple sclerosis (MS), which has strong predilection for Caucasian populations, whereas NMO is more frequent in non-Caucasian individuals. The objective this study compare the HLA-DRB profile Brazilian Mulatto patients with spectrum disorders (NMOSDs) that observed MS and healthy controls. Twenty seven NMOSD (20 women), all seropositive NMO-IgG, 29 28 blood donors were evaluated allele groups. HLA-DRB1*03 group...
Human Leucocyte Antigen G (HLA-G) belongs to the family of nonclassical HLA class I genes, located within major histocompatibility complex (MHC). HLA-G has been target most recent research regarding function genes. The main features that distinguish from classical genes are: a) limited protein variability; b) alternative splicing generating several membrane bound and soluble isoforms; c) short cytoplasmic tail; d) modulation immune response (immune tolerance); e) restricted expression...
Background Chronic Chagas cardiomyopathy (CCC), a life-threatening inflammatory dilated cardiomyopathy, affects 30% of the approximately 8 million patients infected by Trypanosoma cruzi. Even though Th1 T cell-rich myocarditis plays pivotal role in CCC pathogenesis, little is known about factors controlling cell migration to myocardium. Methods and Results Using confocal immunofluorescence quantitative PCR, we studied surface staining gene expression CXCR3, CCR4, CCR5, CCR7, CCR8 receptors...
Patients with COVID-19 predominantly have a respiratory tract infection and acute lung failure is the most severe complication. While molecular basis of SARS-CoV-2 immunopathology still unknown, it well established that associated hyper-inflammation tissue damage. Matrix metalloproteinases (MMPs) contribute to destruction in many pathological situations, activity MMPs leads release bioactive mediators inflammatory properties. We sought characterize scenario which could influence pathogenesis...
// Layale Yaghi 1, 2, 3 , Isabelle Poras 2 Renata T. Simoes 4 Eduardo A. Donadi 5 Jörg Tost 6, 7 Antoine Daunay 6 Bibiana Sgorla de Almeida Edgardo D. Carosella Philippe Moreau 1 Commissariat à l'Energie Atomique et aux Energies Alternatives, Institut des Maladies Emergentes Thérapies Innovantes, Service Recherches en Hémato-Immunologie, Hôpital Saint-Louis, Paris, France Université Paris-Diderot, Sorbonne Paris-Cité, UMR E5, Universitaire d'Hématologie, Lebanese University, School of...
Brain derived neurotrophic factor (BDNF) has been related to neuroprotection in a series of central nervous system diseases, although its role multiple sclerosis (MS) was only partially investigated. In this work, we aimed evaluate the plasma levels BDNF from 29 MS patients and 24 control subjects. had decreased comparison with healthy controls. increased significantly after relapse. Our results provide some evidence for involvement pathogenesis suggest neurotrophin during recovery acute...
Ionizing radiation (IR) imposes risks to human health and the environment. IR at low doses dose rates has potency initiate carcinogenesis. Genotoxic environmental agents such as trigger a cascade of signal transduction pathways for cellular protection. In this study, using cDNA microarray technique, we monitored gene expression profiles in lymphocytes derived from radiation-exposed individuals (radiation workers). Physical dosimetry records on these patients indicated that absorbed ranged...
Considering that downregulation of HLA expression could represent a potential mechanism for breast carcinogenesis and metastasis, the aim present study was to use immunohistochemical methods analyze HLA-Ia, HLA-DR, HLA-DQ, HLA-E, HLA-G in invasive ductal carcinoma (IDC) relate this profile anatomopathological parameters. Fifty-two IDC from biopsies were stratified according histological differentiation (well, moderately, poorly differentiated) presence metastases axillary lymph nodes. The...
Human leukocyte antigen-G (HLA-G) is a nonclassical major histocompatibility complex (MHC) class I molecule involved in immune tolerance processes, playing an important role the maintenance of semi-allogeneic fetus. Although HLA-G expression restricted normal tissues, it broadly expressed malignant tumors and may favor tumor escape. We analyzed protein mRNA samples from patients with glioblastoma collected France, Denmark, Brazil. found 65 108 20 21 samples. The absence was associated better...