Jonatan C. S. de Carvalho
A5083126153- COVID-19 Clinical Research Studies
- Lipid Membrane Structure and Behavior
- Pharmacological Receptor Mechanisms and Effects
- Inflammasome and immune disorders
- Extracellular vesicles in disease
- Sphingolipid Metabolism and Signaling
- Inflammation biomarkers and pathways
- Cannabis and Cannabinoid Research
- COVID-19 Impact on Reproduction
- Long-Term Effects of COVID-19
- Metabolomics and Mass Spectrometry Studies
- Stress Responses and Cortisol
- S100 Proteins and Annexins
- Nanopore and Nanochannel Transport Studies
- Mass Spectrometry Techniques and Applications
- Hormonal and reproductive studies
- Pancreatic function and diabetes
- Advanced Proteomics Techniques and Applications
- Ectopic Pregnancy Diagnosis and Management
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Nanoparticle-Based Drug Delivery
- Reproductive System and Pregnancy
- Chronic Obstructive Pulmonary Disease (COPD) Research
Universidade de São Paulo
2020-2025
Universidade de Ribeirão Preto
2020-2023
SUPERA Park of Innovation and Technology of Ribeirão Preto
2023
Patients with COVID-19 predominantly have a respiratory tract infection and acute lung failure is the most severe complication. While molecular basis of SARS-CoV-2 immunopathology still unknown, it well established that associated hyper-inflammation tissue damage. Matrix metalloproteinases (MMPs) contribute to destruction in many pathological situations, activity MMPs leads release bioactive mediators inflammatory properties. We sought characterize scenario which could influence pathogenesis...
Uncontrolled inflammatory responses play a critical role in coronavirus disease (COVID-19). In this context, because the triggering-receptor expressed on myeloid cells-1 (TREM-1) is considered an intrinsic amplifier of signals, study investigated soluble TREM-1 (sTREM-1) as biomarker severity and mortality COVID-19. Based their clinical scores, we enrolled COVID-19 positive patients (
Lipid and cholinergic mediators are inflammatory regulators, but their role in the immunopathology of COVID-19 is still unclear. Here, we used human blood tracheal aspirate (TA) to investigate whether acetylcholine (Ach), fatty acids (FAs), derived lipid (LMs) associated with severity. First, analyzed perturbation profile induced by SARS-CoV-2 infection transcriptional genes related ACh FA/LM pathways. Blood TA were for metabolomic lipidomic analyses quantification leukocytes, cytokines,...
COVID-19 is associated with a dysregulated immune response. Currently, several medicines are licensed for the treatment of this disease. Due to their significant role in inhibiting pro-inflammatory cytokines and lipid mediators, glucocorticoids (GCs) have attracted great deal attention. Similarly, endocannabinoid (eCB) system regulates various physiological processes including immunological Additionally, during inflammatory thrombotic processes, phospholipids from cell membranes cleaved...
The non-classical histocompatibility antigen G (HLA-G) is an immune checkpoint molecule that has been implicated in viral disorders. We evaluated the plasma soluble HLA-G (sHLA-G) 239 individuals, arranged COVID-19 patients (n = 189) followed up at home or a hospital, and healthy controls 50). Increased levels of sHLA-G were observed irrespective facility care, gender, age, presence comorbidities. Compared with controls, increased as far disease severity progressed; however, decreased...
SARS-CoV-2 infection triggers distinct patterns of disease development characterized by significant alterations in host regulatory responses. Severe cases exhibit profound lung inflammation and systemic repercussions. Remarkably, critically ill patients display a "lipid storm", influencing the inflammatory process tissue damage. Sphingolipids (SLs) play pivotal roles various cellular processes, including inflammation, metabolic disorders, cancer. In this study, we employed high-resolution...
COVID-19 has a broad spectrum of clinical manifestations associated with the host immune response heterogeneity. Despite advances in research, it is still crucial to seek panel molecular markers that enable accurate stratification patients. Here, we performed study combined analysis blood transcriptome, demographic data, aspects and laboratory findings from 66 participants classified into different degrees severity healthy subjects. We identified perturbation blood-leukocyte transcriptional...
Abstract Cytokine storms and hyperinflammation, potentially controlled by glucocorticoids, occur in COVID-19; the roles of lipid mediators acetylcholine (ACh) how glucocorticoid therapy affects their release Covid-19 remain unclear. Blood bronchoalveolar lavage (BAL) samples from SARS-CoV-2- non-SARS-CoV-2-infected subjects were collected for metabolomic/lipidomic, cytokines, soluble CD14 (sCD14), ACh, CD36-expressing monocyte/macrophage subpopulation analyses. Transcriptome reanalysis...
Abstract Background The uncontrolled inflammatory response plays a critical role in the novel coronavirus disease (COVID-19) and triggering receptor expressed on myeloid cells-1 (TREM-1) is thought to be intricate signal amplification. This study aims investigate association between soluble TREM-1 (sTREM-1) COVID-19 as prognostic biomarker predict severity, lethality clinical management. Methods We enrolled 91 patients with domiciliary care (44 patients) or hospital (47 patients), who were...
Abstract Lipidomics, a subfield of metabolomics, involves the comprehensive analysis lipids within biological systems and has become cornerstone biomedical research, driven by recent technological advancements. Lipids are crucial biomolecules in cellular functions have been increasingly recognized for their roles physiological pathological processes. This study focuses on innovative strategies developing, validating, applying analytical methods untargeted lipidomics using liquid...
SARS-CoV-2 infection triggers distinct patterns of disease development, characterized by significant alterations in host regulatory responses. Severe cases exhibit profound lung inflammation and systemic repercussions. Remarkably, critically ill patients display a "lipid storm", influencing the inflammatory process tissue damage. Sphingolipids (SL) play pivotal roles various cellular processes, including inflammation, metabolic disorders, cancer. In this study, we employed...
Background: Adequate management of COVID-19 needs data that predict its outcomes in men and explain sexual dimorphism. This study evaluated immunoendocrine mediators, gene expression profiles their correlations a large cohort controls patients with different clinical presentations.Methods: Analyses public databank confirmed the sex bias for unfavorable Brazilian infected SARS-CoV-2. A local was then assessed levels steroids immune mediators. global blood leukocytes were correlated....