Isabelle C. Guarneri
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Pharmacological Receptor Mechanisms and Effects
- Inflammation biomarkers and pathways
Universidade de Ribeirão Preto
2020-2021
Universidade de São Paulo
2020-2021
Abstract Cytokine storms and hyperinflammation, potentially controlled by glucocorticoids, occur in COVID-19; the roles of lipid mediators acetylcholine (ACh) how glucocorticoid therapy affects their release Covid-19 remain unclear. Blood bronchoalveolar lavage (BAL) samples from SARS-CoV-2- non-SARS-CoV-2-infected subjects were collected for metabolomic/lipidomic, cytokines, soluble CD14 (sCD14), ACh, CD36-expressing monocyte/macrophage subpopulation analyses. Transcriptome reanalysis...
Abstract Background The uncontrolled inflammatory response plays a critical role in the novel coronavirus disease (COVID-19) and triggering receptor expressed on myeloid cells-1 (TREM-1) is thought to be intricate signal amplification. This study aims investigate association between soluble TREM-1 (sTREM-1) COVID-19 as prognostic biomarker predict severity, lethality clinical management. Methods We enrolled 91 patients with domiciliary care (44 patients) or hospital (47 patients), who were...