A5034029053- COVID-19 Clinical Research Studies
- Inflammation biomarkers and pathways
- Lipid Membrane Structure and Behavior
- Pharmacological Receptor Mechanisms and Effects
- Extracellular vesicles in disease
- Diet and metabolism studies
- Sphingolipid Metabolism and Signaling
- Long-Term Effects of COVID-19
- Inflammasome and immune disorders
- Adipose Tissue and Metabolism
- Hemoglobinopathies and Related Disorders
- COVID-19 Impact on Reproduction
- Metabolomics and Mass Spectrometry Studies
- Healthcare Regulation
- Hepatitis C virus research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Cannabis and Cannabinoid Research
- Advanced Proteomics Techniques and Applications
- COVID-19 and Mental Health
- Bioactive Compounds and Antitumor Agents
- Nanopore and Nanochannel Transport Studies
- Complement system in diseases
- Herbal Medicine Research Studies
- Reproductive System and Pregnancy
Universidade de São Paulo
2020-2025
Universidade de Ribeirão Preto
2021-2025
Universidade Federal do Amazonas
2019-2024
Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas
2016-2021
Institute of Biomedical Science
2021
Weatherford College
2021
Patients with COVID-19 predominantly have a respiratory tract infection and acute lung failure is the most severe complication. While molecular basis of SARS-CoV-2 immunopathology still unknown, it well established that associated hyper-inflammation tissue damage. Matrix metalloproteinases (MMPs) contribute to destruction in many pathological situations, activity MMPs leads release bioactive mediators inflammatory properties. We sought characterize scenario which could influence pathogenesis...
Uncontrolled inflammatory responses play a critical role in coronavirus disease (COVID-19). In this context, because the triggering-receptor expressed on myeloid cells-1 (TREM-1) is considered an intrinsic amplifier of signals, study investigated soluble TREM-1 (sTREM-1) as biomarker severity and mortality COVID-19. Based their clinical scores, we enrolled COVID-19 positive patients (
Lipid and cholinergic mediators are inflammatory regulators, but their role in the immunopathology of COVID-19 is still unclear. Here, we used human blood tracheal aspirate (TA) to investigate whether acetylcholine (Ach), fatty acids (FAs), derived lipid (LMs) associated with severity. First, analyzed perturbation profile induced by SARS-CoV-2 infection transcriptional genes related ACh FA/LM pathways. Blood TA were for metabolomic lipidomic analyses quantification leukocytes, cytokines,...
Immunoglobulin G (IgG) antibodies play an important role in the immune response against viruses such as SARS-CoV-2. As effector functions of IgG are modulated by N -glycosylation Fc region, structure and possible function -glycome has been under investigation relation to divergent COVID-19 disease courses. Through LC-MS analysis we studied both total IgG1 spike protein-specific glycosylation 129 German 163 Brazilian patients representing diverse patient populations. We found that...
COVID-19 is associated with a dysregulated immune response. Currently, several medicines are licensed for the treatment of this disease. Due to their significant role in inhibiting pro-inflammatory cytokines and lipid mediators, glucocorticoids (GCs) have attracted great deal attention. Similarly, endocannabinoid (eCB) system regulates various physiological processes including immunological Additionally, during inflammatory thrombotic processes, phospholipids from cell membranes cleaved...
Recent evidence suggests that generation of neutrophil extracellular traps (NETosis), one the components immunothrombosis, is associated with pathogenesis both venous thromboembolism and sickle cell disease (SCD). NETosis a complex process regulated by several proteins such as peptidyl arginine deaminase 4 (PADI4), elastase (ELANE), myeloperoxidase (MPO). Among these regulators, PADI4 responsible histone citrullination, an essential step for NETosis. Accordingly, its inhibition has been...
The non-classical histocompatibility antigen G (HLA-G) is an immune checkpoint molecule that has been implicated in viral disorders. We evaluated the plasma soluble HLA-G (sHLA-G) 239 individuals, arranged COVID-19 patients (n = 189) followed up at home or a hospital, and healthy controls 50). Increased levels of sHLA-G were observed irrespective facility care, gender, age, presence comorbidities. Compared with controls, increased as far disease severity progressed; however, decreased...
SARS-CoV-2 infection triggers distinct patterns of disease development characterized by significant alterations in host regulatory responses. Severe cases exhibit profound lung inflammation and systemic repercussions. Remarkably, critically ill patients display a "lipid storm", influencing the inflammatory process tissue damage. Sphingolipids (SLs) play pivotal roles various cellular processes, including inflammation, metabolic disorders, cancer. In this study, we employed high-resolution...
COVID-19 has a broad spectrum of clinical manifestations associated with the host immune response heterogeneity. Despite advances in research, it is still crucial to seek panel molecular markers that enable accurate stratification patients. Here, we performed study combined analysis blood transcriptome, demographic data, aspects and laboratory findings from 66 participants classified into different degrees severity healthy subjects. We identified perturbation blood-leukocyte transcriptional...
The therapeutic strategies used in the treatment of hepatitis C are essentially based on combination direct-acting antiviral agents (DAAs). This therapy has been shown to be very effective relation patient adherence and high rates sustained virological response (SVR). However, immunological dynamics patients infected with HCV is poorly understood. fact led us investigate immune system naive experienced patients, who we followed before three months after end treatment. In this study, 35...
Abstract Cytokine storms and hyperinflammation, potentially controlled by glucocorticoids, occur in COVID-19; the roles of lipid mediators acetylcholine (ACh) how glucocorticoid therapy affects their release Covid-19 remain unclear. Blood bronchoalveolar lavage (BAL) samples from SARS-CoV-2- non-SARS-CoV-2-infected subjects were collected for metabolomic/lipidomic, cytokines, soluble CD14 (sCD14), ACh, CD36-expressing monocyte/macrophage subpopulation analyses. Transcriptome reanalysis...
Abstract Background The uncontrolled inflammatory response plays a critical role in the novel coronavirus disease (COVID-19) and triggering receptor expressed on myeloid cells-1 (TREM-1) is thought to be intricate signal amplification. This study aims investigate association between soluble TREM-1 (sTREM-1) COVID-19 as prognostic biomarker predict severity, lethality clinical management. Methods We enrolled 91 patients with domiciliary care (44 patients) or hospital (47 patients), who were...
Objective/Background: Sickle cell anemia (SCA) is associated with increased levels of extracellular heme, which a key mediator inflammation in this condition. Despite abundant evidence supporting concept and animal models, few studies addressed the association between heme development severity acute vasoocclusive crises (VOC) humans. Methods: A cross-sectional study was conducted patients VOC. Total were measured both plasma serum at admission after convalescence, correlated other clinical...
<title>Abstract</title> COVID-19 caused the pandemic situation experienced since beginning of 2020, and many countries faced rapid spread severe. Mechanisms interaction between virus host were observed during acute phase, but few data are available when related to immunity dynamics in convalescents. We conducted a cross-sectional study, with 51 healthy donors 62 convalescent patients, which these had two-month follow-up after symptoms recovery. Venous blood sample was obtained from all...
The microbial naphthoquinone 3,5,8-TMON and its derivatives showed great anti-inflammatory activity, regulating cytokines with promising activity mitigating COVID-19 inflammatory impacts.
The aims were to identify the symptoms and comorbidities predictive for severe illness analyse mild-term health sequelae in Brazilian recovered from COVID-19. Eighty-four participants divided into mild (n = 16), moderate 51), 9) or critical 8) gravity. A standardized assessment included: anamnesis comorbidities; cardiorespiratory system, body composition, haematological immunological indicators, physical fitness analyze sequelae. Participants with higher gravity presented fever, fatigue...
Abstract Lipidomics, a subfield of metabolomics, involves the comprehensive analysis lipids within biological systems and has become cornerstone biomedical research, driven by recent technological advancements. Lipids are crucial biomolecules in cellular functions have been increasingly recognized for their roles physiological pathological processes. This study focuses on innovative strategies developing, validating, applying analytical methods untargeted lipidomics using liquid...
SARS-CoV-2 infection triggers distinct patterns of disease development, characterized by significant alterations in host regulatory responses. Severe cases exhibit profound lung inflammation and systemic repercussions. Remarkably, critically ill patients display a &quot;lipid storm&quot;, influencing the inflammatory process tissue damage. Sphingolipids (SL) play pivotal roles various cellular processes, including inflammation, metabolic disorders, cancer. In this study, we employed...