A5058080863- Galectins and Cancer Biology
- RNA Interference and Gene Delivery
- S100 Proteins and Annexins
- Signaling Pathways in Disease
- Inflammation biomarkers and pathways
- Muscle Physiology and Disorders
- Rabies epidemiology and control
- Inflammasome and immune disorders
- Cancer Genomics and Diagnostics
- Venomous Animal Envenomation and Studies
- Immune Response and Inflammation
- Education and Digital Technologies
- Sepsis Diagnosis and Treatment
- GDF15 and Related Biomarkers
- Alzheimer's disease research and treatments
- Streptococcal Infections and Treatments
- Clusterin in disease pathology
- Science and Education Research
- Leptospirosis research and findings
- Advanced biosensing and bioanalysis techniques
- Computational Drug Discovery Methods
- Virus-based gene therapy research
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
Universidade Federal de Uberlândia
2014-2025
Instituto Evandro Chagas
2023
Universidade de São Paulo
2020-2023
Patients with COVID-19 predominantly have a respiratory tract infection and acute lung failure is the most severe complication. While molecular basis of SARS-CoV-2 immunopathology still unknown, it well established that associated hyper-inflammation tissue damage. Matrix metalloproteinases (MMPs) contribute to destruction in many pathological situations, activity MMPs leads release bioactive mediators inflammatory properties. We sought characterize scenario which could influence pathogenesis...
Uncontrolled inflammatory responses play a critical role in coronavirus disease (COVID-19). In this context, because the triggering-receptor expressed on myeloid cells-1 (TREM-1) is considered an intrinsic amplifier of signals, study investigated soluble TREM-1 (sTREM-1) as biomarker severity and mortality COVID-19. Based their clinical scores, we enrolled COVID-19 positive patients (
Idiopathic pulmonary fibrosis (IPF) is a progressive and incurable chronic interstitial lung disease characterized by excessive impaired function. Current treatments, such as pirfenidone nintedanib, slow progression but fail to halt or reverse fibrosis, highlighting the need for novel approaches. Activin A, which belongs TGF-β superfamily, implicated in various fibrosis-related mechanisms, including epithelial–mesenchymal transition (EMT), process where epithelial cells acquire mesenchymal...
There is increasing evidence that cancer dissemination and metastasis establishment may not only be due to the movement of tumor cells. Content extracellular vesicles (EVs) secreted by cells also reflect origin these Some molecules constitute EVs have already been used as targets for detection specific tumors. However, best our knowledge, from biopsies plasma yet compared nor thoroughly investigated triggers malignant transformation metastatic niche formation. To evaluate role in cellular...
Abstract Cell-free DNA is present in different biological fluids and when released by tumor cells may contribute to pro-tumor events such as malignant transformation of adjacent the metastasis. Thus, this study analyzed effect cell-free DNA, isolated from blood prostate cancer patients, on non-tumor cell lines (RWPE-1 PNT-2). To achieve this, we performed quantification characterization assays, evaluation gene miRNA expression profiling focused progression EMT, metabolomics mass spectrometry...
COVID-19 has a broad spectrum of clinical manifestations associated with the host immune response heterogeneity. Despite advances in research, it is still crucial to seek panel molecular markers that enable accurate stratification patients. Here, we performed study combined analysis blood transcriptome, demographic data, aspects and laboratory findings from 66 participants classified into different degrees severity healthy subjects. We identified perturbation blood-leukocyte transcriptional...
Skeletal muscle has the intrinsic ability to self-repair through a multifactorial process, but many aspects of its cellular and molecular mechanisms are not fully understood. There is increasing evidence that some members mammalian β-galactoside-binding protein family (galectins) involved in muscular repair process (MRP), including galectin-3 (Gal-3). However, there questions about role this on self-repair. Here, we demonstrate endogenous Gal-3 required for: (i) vivo by using chloride-barium...
Gene therapy emerged as a mighty alternative for conventional treatment of multiple diseases. It has been defined product “that mediate their effects by transcription and/or translation transferred genetic material integrating into the host genome and that are administered nucleic acids, viruses, or genetically engineered microorganisms. The products may be used to modify cells in vivo ex prior administration recipient”. first therapeutic gene human trial was conducted 1990 Michael R....
Sepsis poses a significant challenge due its lethality, involving multiple organ dysfunction and impaired immune responses. Among several factors affecting sepsis, monocytes play crucial role; however, their phenotype, proteomic profile, function in septic shock remain unclear. Our aim was to fully characterize the subpopulations profiles of seen cases discuss possible impact on disease. Peripheral blood monocyte were phenotype based CD14/CD16 expression by flow cytometry, proteins extracted...
Rabies is an ancient neuroinvasive viral (genus Lyssavirus, family Rhabdoviridae) disease affecting approximately 59,000 people worldwide. The central nervous system (CNS) targeted, and rabies has a case fatality rate of almost 100% in humans animals. entirely preventable through proper vaccination, thus, the highest incidence typically observed developing countries, mainly Africa Asia. However, there are still cases European countries US. Recently, demographic, increasing income levels,...
"Embaralhando Mendel e suas leis" é um jogo facilitador da aprendizagem das leis de Mendel, voltado aos alunos do ensino médio. No desenvolvimento atividade, importantes conceitos Genética são abordados, tais como segregação independente, formação gametas, fecundação, genótipo, fenótipo transmissão características genéticas. Pretende-se por meio desse desenvolver uma atividade participativa, dinâmica integradora, que mistura conteúdo didático, competitividade atenção.
ABSTRACT Skeletal muscle has the intrinsic ability to self-repair through a multifactorial process, but many aspects of its cellular and molecular mechanisms are not fully understood. There is increasing evidence that some members mammalian β-galactoside-binding protein family (galectins) involved in muscular repair process (MRP), including galectin-3 (Gal-3). However, there questions about role this on self-repair. Here, we demonstrate endogenous Gal-3 required for: i) vivo using...
Background Leptospirosis is a zoonosis caused by the infection of pathogenic bacteria genera Leptospira, often transmitted direct or indirect contact with urine infected animal hosts [1]. In national territory, leptospirosis considered an endemic disease, high incidence in raining seasons, but occurring during whole year [2]. From all cases, 15% evolve to icteric form, serious clinic manifestations, as severe icteric, hemorrhages and kidney including lethal onset 50% cases [3]. membrane...
<b>Background:</b> Activin A has been reported to play a proinflammatory role in the development and progression of idiopathic pulmonary fibrosis (IPF). Follistatin, an activin inhibitor, is activated by feedback loop causing increased production, resulting fibrosis. <b>Aims:</b> To develop binding peptides with ability inhibiting action without triggering involving follistatin overexpression. We hypothesized that inhibition this mechanism can ameliorate IPF symptoms slow disease...
Abstract Cell free DNA (cfDNA) are present at various biological fluids and when released by tumor cells it can contribute with the induction of pro-tumorigenic events, such as malignant transformations metastasis. In this work we evaluated effects derived cfDNA, isolated from blood prostate cancer patients, in non-tumoral cellular linages RWPE-1 PNT-2. We quantified, characterized function cfDNA qPCR progression related genes MS-metabolomics. The results showed that was able to induce...