A5049908850- Multiple Sclerosis Research Studies
- Hereditary Neurological Disorders
- Peripheral Neuropathies and Disorders
- Peripheral Nerve Disorders
- Leprosy Research and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Neurological diseases and metabolism
- Genetic Neurodegenerative Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Nerve injury and regeneration
- Epilepsy research and treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Ophthalmology and Eye Disorders
- Systemic Lupus Erythematosus Research
- Trypanosoma species research and implications
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Nerve Injury and Rehabilitation
- Pain Mechanisms and Treatments
- Muscle activation and electromyography studies
- Heart Rate Variability and Autonomic Control
- Neurogenetic and Muscular Disorders Research
- Ion Transport and Channel Regulation
- Metabolism and Genetic Disorders
- Ion channel regulation and function
Universidade de São Paulo
2013-2023
Instituto de Neurociências e Comportamento
2016-2022
Clinics Hospital of Ribeirão Preto
1997-2021
Universidade de Ribeirão Preto
1992-2020
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2018
Universidade Brasil
2016
St. Elizabeth's Medical Center
2014
Tufts University
2014
Hospital Universitário da Universidade de São Paulo
2013
Mayo Clinic
2010
<h3>Importance</h3> Hematopoietic stem cell transplantation (HSCT) represents a potentially useful approach to slow or prevent progressive disability in relapsing-remitting multiple sclerosis (MS). <h3>Objective</h3> To compare the effect of nonmyeloablative HSCT vs disease-modifying therapy (DMT) on disease progression. <h3>Design, Setting, and Participants</h3> Between September 20, 2005, July 7, 2016, total 110 patients with MS, at least 2 relapses while receiving DMT prior year, an...
Coenzyme Q10 (CoQ10) transfers electrons from complexes I and II of the mitochondrial respiratory chain to complex III. There is one published report human CoQ10 deficiency describing two sisters with encephalopathy, proximal weakness, myoglobinuria, lactic acidosis. We a patient who had delayed motor milestones, premature exertional fatigue, episodes exercise-induced pigmenturia. She also developed partial-complex seizures. Serum creatine kinase was approximately four times upper limit...
Until recently, neuromyelitis optica (NMO) was considered to be a sub-type of multiple sclerosis (MS), which has strong predilection for Caucasian populations, whereas NMO is more frequent in non-Caucasian individuals. The objective this study compare the HLA-DRB profile Brazilian Mulatto patients with spectrum disorders (NMOSDs) that observed MS and healthy controls. Twenty seven NMOSD (20 women), all seropositive NMO-IgG, 29 28 blood donors were evaluated allele groups. HLA-DRB1*03 group...
Detection of aquaporin-4-specific immunoglobulin G (IgG) has expanded the spectrum neuromyelitis optica (NMO). Rare reports familial aggregation have suggested a component genetic susceptibility but these mostly antedated discovery NMO-IgG biomarker and recently updated diagnostic criteria.We report case series describing demographic, clinical, neuroimaging, serologic status 12 multiplex NMO pedigrees with total 25 affected individuals.Twenty-one patients (84%) were women. Families Asian (n...
Objectives: We performed responsiveness comparison between the patient-reported Inflammatory Rasch-built Overall Disability Scale (I-RODS) and widely used clinician-reported Neuropathy Cause Treatment–Overall Limitation (INCAT-ONLS) in patients with Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), immunoglobulin M–monoclonal gammopathy of undetermined significance related polyneuropathy (IgM-MGUSP). Methods: One hundred thirty-seven (GBS: 55,...
Delayed Information Processing Speed (IPS) often underlies attention deficits and is particularly evident in patients with traumatic brain injury, Parkinson's disease, depression, dementia, multiple sclerosis. Therefore, it of interest to determine the network that responsible for such essential cognitive function understand IPS develop effective rehabilitation programs. We assessed functional connectivity during performance an adapted version Symbol Digit Modalities Test. Using dynamic...
To investigate the reliability and validity of a Brazilian-Portuguese adaptation Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS).A Brazilian sample 58 multiple sclerosis (MS) patients healthy controls (HC) were administered BICAMS test battery, comprising Symbol Digit Modalities Test (SDMT), California Verbal Learning Second Edition (CVLT2), Visuospatial Memory Revised (BVMTR). Mean differences between groups on tests assessed using analysis covariance (ANCOVA),...
Abstract The phenotype of 16 members a family affected by late‐onset, dominant, progressive, motor and autonomic disorder is described. VAPB (Pro56Ser) mutation was detected in Brazilian families with different phenotypes neuron disorders. In this family, proximal axial muscle weakness atrophy, associated abdominal protrusion, defined the phenotype. Death occurred 10–15 years due to respiratory insufficiency. Tone tendon reflexes were decreased distal tremor common. Sensation preserved....
Abstract Mice were acutely and chronically infected with Trypanosoma cruzi then examined histologically for the presence of lesions in peripheral nervous system. In animals, small lymphocytic macrophagic infiltrates found nerves association intracellular parasites. Little or no nerve damage was present at this stage. large perivascular granulomatous multifocal, predominantly demyelinative neighboring fibers. Similar inflammatory muscles frequently associated vasculitis destruction muscle Our...
The pathology of relapsing-remitting multiple sclerosis (RR-MS) is largely attributed to activated autoreactive effector T lymphocytes. influence microRNAs on the immune response has been shown occur in different pathways lymphocyte differentiation and function. Here, expression miRNAs miR-15a/16-1 PBMC, CD4(+), CD8(+) from RR-MS patients investigated. BCL2, a known target, also analyzed. results have that downregulated CD4(+) cells, whereas BCL2 highly expressed only. Our data suggest can...
Autologous haematopoietic stem-cell transplantation (AHSCT) has been experimented as a treatment in patients affected by severe forms of multiple sclerosis (MS) who failed to respond standard immunotherapy. The rationale AHSCT is 'reboot' the immune system and reconstitute new adaptive immunity. aim our study was identify, through robust unbiased transcriptomic analysis, any changes gene expression T-cells potentially underlying effect underwent non-myeloablative for MS. We evaluated...
Abstract Disability in leprosy is a direct consequence of damage to the peripheral nervous system which usually worse patients with no skin manifestations, an underdiagnosed subtype known as primary neural leprosy. We evaluated clinical, neurophysiological and laboratory findings 164 definite probable diagnoses. To better understand disease progression improve clinical recognition we compared characteristics short (≤12 months) long (&gt;12 duration. Positive negative symptoms mediated by...
Abstract There is no literature report of a detailed morphologic study the aortic depressor nerve. The aim this was to describe general morphological aspects and obtain morphometric parameters for nerve normotensive Wistar rats (n=12). Before studies, nerves were isolated pressure-nerve activity curves obtained. Basal mean arterial pressure 117±5 mm Hg, systolic threshold 100±7 at 50% maximal 115±5 Hg baroreceptor gain 1.99±0.09%/mm Hg. Semithin thin sections proximal distal segments then...
The objective of the present study was to compare morphology unmyelinated fibers in aortic depressor nerves (ADN) spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY). In anesthetized rats, ADN identified by its spontaneous activity synchronous with arterial pulses. Thin sections proximal distal segments were analyzed electron microscopy, a morphometric Schwann cells performed. WKY SHR contain an average 335 ± 68 130 14 fibers, respectively ( P < 0.05), 337 46 242 77 0.05)....