A5035458785- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Ultrasound and Hyperthermia Applications
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Advanced MRI Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Fungal Plant Pathogen Control
- Ultrasound Imaging and Elastography
- MRI in cancer diagnosis
- RNA regulation and disease
- Health Systems, Economic Evaluations, Quality of Life
- Cerebral Venous Sinus Thrombosis
- Radiomics and Machine Learning in Medical Imaging
- Alzheimer's disease research and treatments
- Systemic Sclerosis and Related Diseases
- Complement system in diseases
- Venous Thromboembolism Diagnosis and Management
- Vestibular and auditory disorders
- Viral Infections and Immunology Research
- Brain Tumor Detection and Classification
- Neuroinflammation and Neurodegeneration Mechanisms
- Long-Term Effects of COVID-19
University of Miami
2023-2024
University of Minnesota
2018-2023
Resonance Research (United States)
2019-2022
Twin Cities Orthopedics
2018-2022
University of Minnesota System
2021
The University of Texas Health Science Center at Houston
2011-2021
The University of Texas at Austin
2009-2019
St. Michael's Hospital
2019
Harvard University
2019
University of Southern California
1981-2019
<h3>Importance</h3> Hematopoietic stem cell transplantation (HSCT) represents a potentially useful approach to slow or prevent progressive disability in relapsing-remitting multiple sclerosis (MS). <h3>Objective</h3> To compare the effect of nonmyeloablative HSCT vs disease-modifying therapy (DMT) on disease progression. <h3>Design, Setting, and Participants</h3> Between September 20, 2005, July 7, 2016, total 110 patients with MS, at least 2 relapses while receiving DMT prior year, an...
Accurate detection and classification of purely intracortical lesions in multiple sclerosis (MS) are important understanding their role disease progression impact on the clinical manifestations disease. However, these with conventional MR imaging remains a challenge. Although double inversion recovery (DIR) has been shown to improve sensitivity cortical lesions, this sequence low signal-to-noise ratio (SNR), poor delineation lesion borders, is prone image artifacts. We demonstrate that can...
A double-blind, randomized, controlled study was undertaken to determine whether combined use of interferon β-1a (IFN) 30 μg intramuscularly weekly and glatiramer acetate (GA) 20 mg daily is more efficacious than either agent alone in relapsing-remitting multiple sclerosis.A total 1,008 participants were randomized followed until the last participant enrolled completed 3 years. The primary endpoint reduction annualized relapse rate utilizing a strict definition relapse. Secondary outcomes...
Background: Accurate classification of multiple sclerosis (MS) lesions in the brain cortex may be important understanding their impact on cognitive impairment (CI). Improved accuracy identification/classification cortical was demonstrated a study combining two magnetic resonance imaging (MRI) sequences: double inversion recovery (DIR) and T1-weighted phase-sensitive (PSIR). Objective: To evaluate role intracortical (IC) MS-related CI compare it with mixed (MX), juxtacortical (JX), sum IC +...
Background Gray matter lesions are known to be common in multiple sclerosis (MS) and suspected play an important role disease progression clinical disability. A combination of magnetic resonance imaging (MRI) techniques, double-inversion recovery (DIR), phase-sensitive inversion (PSIR), has been used for detection classification cortical lesions. This study shows that high-resolution three-dimensional (3D) magnetization-prepared rapid acquisition with gradient echo (MPRAGE) improves the by...
The effect of aging on microglial and astrocytic activity in the hypothalamic arcuate nucleus was measured young middle-aged Wistar rats C57BL/6J mice. These putative correlates neuronal degeneration increased significantly between 6 14 months age intact female male rats, 4 13 Although steadily 4, 8.5, did not increase until months.
Objective: To evaluate teriflunomide as add-on therapy to ongoing stable-dosed interferon-β (IFNβ) in patients with relapsing forms of multiple sclerosis (RMS). Methods: A total 118 RMS were randomly assigned 1:1:1 receive oral placebo or teriflunomide, 7 14 mg, once daily for 24 weeks; 86 entered the 24-week extension. The primary objective was safety; secondary objectives effects treatment on disease activity assessed by MRI and relapse rate. Results: Teriflunomide well tolerated a low...
Objective: The purpose of this study was to determine the effects oral teriflunomide on multiple sclerosis (MS) pathology inferred by magnetic resonance imaging (MRI). Methods: Patients ( n=1088) with relapsing MS were randomized once-daily 7 mg or 14 mg, placebo, for 108 weeks. MRI recorded at baseline, 24, 48, 72 and Annualized relapse rate confirmed progression disability (sustained ≥12 weeks) primary key secondary outcomes. principal outcome change in total lesion volume. Results: After...
Abstract Purpose To investigate the utility of caudate nuclei (CN) macro‐ and microstructural metrics as markers gray matter degeneration in healthy adults relapsing‐remitting multiple sclerosis (RRMS) patients. Materials Methods The normal age‐ pathology‐related changes volume (CNV), corresponding diffusion tensor metrics, T 2 relaxation times were measured a cohort 32 (12 men/20 women; age range 21–59 years) age‐matched RRMS patients (8 men/34 21–57 years). Results Smaller values both...
To prospectively perform a direct measurement of fractional anisotropy (FA) and mean diffusivity (MD) in cortical lesions patients with multiple sclerosis (MS).The study was approved by the institutional review board HIPAA compliant; informed consent obtained. Magnetic resonance (MR) images, including double inversion-recovery (DIR), phase-sensitive (PSIR), diffusion-tensor were acquired from nine MS (five women, four men; median age, 47 years) age- sex-matched volunteer control subjects....
Chronic cerebrospinal venous insufficiency (CCSVI) has been implicated in the pathophysiology of multiple sclerosis (MS). We sought to determine whether neurosonography (NS) provides reliable information on cerebral outflow patterns specific MS.This was a single-center, prospective case-control study volunteer MS and non-MS participants. A neurosonologist, blind subjects' diagnosis, used high-resolution B-mode imaging with color spectral Doppler systematically investigate, capture, record...
Quantitative measures derived from magnetic resonance imaging (MRI) have been widely investigated as non-invasive biomarkers in multiple sclerosis (MS). However, the correlation of single with Expanded Disability Status Scale (EDSS) is poor, especially for studies large population samples.To explore MRI-derived EDSS through composite MRI scores.Magnetic images 126 patients relapsing-remitting MS were segmented into white and gray matter, cerebrospinal fluid, T2-hyperintense lesions,...
Large demyelinating lesions with possible mass effect (tumefactive multiple sclerosis or tumefactive demyelination) can be mistaken for tumour-like space-occupying suggesting a malignant outcome.We reviewed our own experience of subjects (n = 28) demyelination to determine the relationship between clinical outcomes and lesion evolution, their different therapies. Patients central nervous system disease were identified from database over last 10 years.No patient increased in extended...
Distinct injuries to various limbic white matter pathways have been reported be associated with different aspects of cognitive dysfunction in multiple sclerosis (MS). Diffusion tensor imaging (DTI) offers a noninvasive method map tissue microstructural organization. We utilized quantitative magnetic resonance methods analyze the main system-white structures MS patients impairment (CI).Ten cognitively nonimpaired (MSNI) and 36 diagnosed CI (MSCI) underwent minimal assessment Cognitive...
Abstract The advent of magnetic resonance imaging has improved our understanding the pathophysiology and natural course multiple sclerosis (MS). ability to show evolution MS lesions on sequential scans brought it be one endpoints in clinical trials for disease-modifying therapies. Based most updated consensus guidelines from American (Consortium Centers) European (Magnetic Resonance Imaging MS) boards experts MS, this document shows relevant landmarks related findings, diagnostic criteria,...
The robustness of brain structural networks, estimated from diffusion MRI data, may be relevant to cognition. We investigate whether measures network robustness, such as Ollivier-Ricci curvature, can explain cognitive impairment in multiple sclerosis (MS). assessed local (i.e. cortical area) and/or global whole brain) differs between cognitively impaired (MSCI) and non-impaired (MSNI) MS patients. 50 patients, with Expanded Disability Status Scale mean (m): 3.2, disease duration m: 12 years,...
Purpose Postacquisition combination of three‐dimensional T2‐weighted (T2w) and fluid‐attenuated inversion recovery (FLAIR) images can improve the visualization brain lesions in multiple sclerosis (MS). However, an optimal way to combine these has not been described so far. The main objective this study is investigate T2w FLAIR conspicuity MS lesions. Materials Methods We determined parameters for a generalized multiplicative image which maximize contrast‐to‐noise ratio (CNR) between...
Introduction Previous studies reveal that a newly described white matter pathway, the frontal aslant tract (FAT), connecting inferior and superior gyri has role in speech language functions. We explored of this phonemic semantic fluency tasks cohort multiple sclerosis patients diagnosed with cognitive impairment.Methods Thirty-five MS varying degrees impairment underwent diffusion tensor imaging Controlled Associated Word Test. Fractional anisotropy (FA) FAT arcuate fasciculus (AF) were...
Alemtuzumab is effective in reducing relapse rate and disability, but limited data exist on its effect cognitive function relapsing multiple sclerosis (RMS). The present study assessed neurocognitive safety associated with alemtuzumab treatment RMS.This longitudinal, single-arm, prospective included people RMS (aged 25-55 years) who were treated clinical practice the United States of America Canada. first participant was enrolled December 2016. primary endpoint change from baseline to...