A5086059428- Multiple Sclerosis Research Studies
- Systemic Sclerosis and Related Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Peripheral Neuropathies and Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Microscopic Colitis
- Inflammatory Bowel Disease
- Mycobacterium research and diagnosis
- Family Support in Illness
- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Acute Lymphoblastic Leukemia research
- Polyomavirus and related diseases
- Powdery Mildew Fungal Diseases
- Chronic Disease Management Strategies
- Cytokine Signaling Pathways and Interactions
- Family and Disability Support Research
- Dementia and Cognitive Impairment Research
- Gut microbiota and health
- Pathogenesis and Treatment of Hiccups
- Cervical Cancer and HPV Research
- Mental Health Treatment and Access
- Health, psychology, and well-being
University of Manitoba
2016-2025
Dalhousie University
2015-2025
Nova Scotia Health Authority
2016-2025
Health Sciences Centre
2015-2024
Children's Hospital of Philadelphia
2013-2024
Montreal Neurological Institute and Hospital
2000-2024
McGill University
2002-2024
Hospital for Sick Children
2013-2024
Manitoba Health
2013-2024
The University of Texas Southwestern Medical Center
2022-2024
Background: High-quality epidemiologic data worldwide are needed to improve our understanding of disease risk, support health policy meet the diverse needs people with multiple sclerosis (MS) and advocacy efforts. Objectives: The Atlas MS is an open-source global compendium regarding epidemiology availability resources for reported at country, regional levels. Methods: Country representatives their sources via survey between September 2019 March 2020, covering prevalence incidence in males,...
<h3>Objective</h3> To generate a national multiple sclerosis (MS) prevalence estimate for the United States by applying validated algorithm to administrative health claims (AHC) datasets. <h3>Methods</h3> A was applied private, military, and public AHC datasets identify adult cases of MS between 2008 2010. In each dataset, we determined 3-year cumulative overall stratified age, sex, census region. We insurance-specific stratum-specific estimates 2010 US Census data pooled findings calculate...
To assess the characteristics of 6-min walk (6MW) in multiple sclerosis (MS) subjects varied disability, and controls. correlation 6MW to subjective measures fatigue, health status ambulation using modified fatigue impact scale (MFIS), short form-36 Health Questionnaire physical component score MS walking (MSWS).Forty expanded disability [(EDSS) 0-6.5] 20 control were recruited from a outpatient clinic. Subjects completed survey material three 6MWs with 1-h interval rest single study...
Objective To develop recommendations for disease-modifying therapy (DMT) multiple sclerosis (MS). Methods A multidisciplinary panel developed DMT recommendations, integrating findings from a systematic review; followed an Institute of Medicine–compliant process to ensure transparency and patient engagement; modified Delphi consensus–based concerning starting, switching, stopping DMTs pertinent people with relapsing-remitting MS, secondary progressive primary clinically isolated syndromes...
Vascular comorbidity adversely influences health outcomes in several chronic conditions. comorbidities are common multiple sclerosis (MS), but their impact on disease severity is unknown. may contribute to the poorly understood heterogeneity MS severity. Treatment of vascular represent an avenue for treating MS.
Immune-mediated inflammatory disease (IMID) represents a substantial health concern. It is widely recognized that IMID patients are at higher risk for developing secondary inflammation-related conditions. While an ambiguous etiology common to all IMIDs, in recent years, considerable knowledge has emerged regarding the plausible role of gut microbiome IMIDs. This study used 16S rRNA gene amplicon sequencing compare microbiota with Crohn's (CD; N = 20), ulcerative colitis (UC; 19), multiple...
<b>Objective:</b> Several studies suggest an increasing prevalence of multiple sclerosis (MS) in Canada. We aimed to validate a case definition for MS using administrative health insurance data, and describe the incidence Manitoba, <b>Methods:</b> used provincial claims data identify persons with demyelinating disease International Classification Diseases 9/10 codes prescription claims. To definition, questionnaires were mailed 2,000 randomly selected encounter disease, requesting permission...
Identifying the course of demyelinating disease associated with myelin oligodendrocyte glycoprotein (MOG) autoantibodies is critical to guide appropriate treatment choices.To characterize serial anti-MOG antibody serologies and clinical imaging features at presentation during follow-up in an inception cohort prospectively monitored children acquired demyelination.In this prospective study, study participants were recruited from July 2004 February 2017 through multicenter Canadian Pediatric...
Psychiatric comorbidity in inflammatory bowel disease (IBD) is well known; however, data from a truly representative sample are sparse. We aimed to estimate the incidence and prevalence of psychiatric disorders an IBD cohort compared with matched without IBD. Using population-based administrative health Manitoba, Canada, we identified all persons incident 1989 2012 general population (5:1). applied validated algorithms for IBD, depression, anxiety disorders, bipolar disorder, schizophrenia...
To evaluate the direct and indirect influences of physical comorbidity, symptoms depression anxiety, fatigue, disability on health-related quality life (HRQoL) in persons with multiple sclerosis (MS).A large (n = 949) sample adults MS was recruited from 4 Canadian clinics. HRQoL assessed using patient-reported Health Utilities Index Mark 3. Expanded Disability Status Scale scores, depression, fatigue were evaluated as predictors a cross-sectional path analysis.All significantly associated...
We aimed to compare survival in the multiple sclerosis (MS) population with a matched cohort from general population, and evaluate association of comorbidity both populations.Using population-based administrative data, we identified 5,797 persons MS 28,807 controls on sex, year birth, region. estimated annual mortality rates. Using Cox proportional hazards regression, evaluated between status mortality, stratifying by birth cohort, adjusting for socioeconomic status, compared causes death...
To assess the association between diet quality and intake of specific foods with disability symptom severity in people multiple sclerosis (MS).In 2015, participants North American Research Committee on MS (NARCOMS) Registry completed a dietary screener questionnaire that estimates fruits, vegetables legumes, whole grains, added sugars, red/processed meats. We constructed an overall score for each individual based these food groups; higher scores denoted healthier diet. assessed status as...
<h3>Objective</h3> Emerging evidence suggests that comorbidity may influence disability outcomes in multiple sclerosis (MS); we investigated the association between psychiatric and MS progression a large multiclinic population. <h3>Methods</h3> This retrospective cohort study accessed prospectively collected information from linked clinical population-based health administrative databases Canadian provinces of British Columbia Nova Scotia. Persons with who had depression, anxiety, or bipolar...