A5102843054- Cerebral Palsy and Movement Disorders
- Neonatal and fetal brain pathology
- Epilepsy research and treatment
- Infant Development and Preterm Care
- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Pharmacological Effects and Toxicity Studies
- Family and Disability Support Research
- Neonatal Respiratory Health Research
- Blood Coagulation and Thrombosis Mechanisms
- Neurogenetic and Muscular Disorders Research
- Cerebral Venous Sinus Thrombosis
- Neurological and metabolic disorders
- Metabolism and Genetic Disorders
- Hepatitis Viruses Studies and Epidemiology
- Botulinum Toxin and Related Neurological Disorders
- Blood transfusion and management
- Travel-related health issues
- Hereditary Neurological Disorders
- Genetics and Neurodevelopmental Disorders
- Ion channel regulation and function
- Blood donation and transfusion practices
- Asthma and respiratory diseases
- Neuroscience and Neuropharmacology Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
United Cerebral Palsy
2019-2023
Janeway Children's Health and Rehabilitation Centre
2007-2022
Memorial University of Newfoundland
1996-2021
Deleted Institution
2021
Centre National pour la Recherche Scientifique et Technique (CNRST)
2021
Holland Bloorview Kids Rehabilitation Hospital
2019-2020
University of Toronto
2019-2020
Izaak Walton Killam Health Centre
1991-2020
Centre Hospitalier Universitaire de Sherbrooke
2019-2020
Family Research Institute
2020
Cerebral sinovenous thrombosis in children is a serious disorder, and information needed about its prevention treatment.
The incidence of acquired demyelination the CNS (acquired demyelinating syndromes [ADS]) in children is unknown. It important that physicians recognize features ADS to facilitate care and appreciate future risk multiple sclerosis (MS).To determine incidence, clinical features, familial autoimmune history, acute management Canadian with ADS.Incidence case-specific data were obtained through Pediatric Surveillance Program from April 1, 2004, March 31, 2007. Before study initiation, a survey...
<b>Objective: </b> To examine outcome and explore for prognostic markers in a cohort <10 years following neonatal seizures. <b>Methods: We prospectively diagnosed clinical seizures with high specificity true epileptic population-based setting of all live newborns the province Newfoundland, Canada, between 1990 1995. Children were followed by specialized provincial health services. Follow-up data collected on epilepsy, physical cognitive impairments, other heath issues. <b>Results: Data...
Cerebral palsy (CP) is the most common abnormality of motor development and causes lifelong impairment. Early diagnosis therapy can improve outcomes, but early identification infants at risk remains challenging.
<h3>Importance</h3> The recognition of magnetic resonance imaging (MRI) features associated with distinct causes myelitis in children is essential to guide investigations and support diagnostic categorization. <h3>Objective</h3> To determine the clinical MRI outcomes spinal cord involvement pediatric myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), multiple sclerosis (MS), seronegative monophasic myelitis. <h3>Design, Setting, Participants</h3> In this cohort study,...
Abstract Introduction: We carried out a population-based study of dystrophin mutations in patients followed by members the Canadian Paediatric Neuromuscular Group (CPNG) over ten-year period. Objectives: aimed to describe changes diagnostic testing for dystrophinopathy and determine frequency from 2000 2009. Methods: De-identified data containing clinical phenotypes, methods, mutational reports CPNG centres January December 2009 were analyzed using descriptive statistics. Results: 773 had...
Few prospective studies have systematically evaluated the extent of recovery from incident acquired demyelinating syndromes (ADS) central nervous system in children.In a national cohort study pediatric ADS, severity attack and by 12 months were evaluated. Annual evaluations used to determine current diagnoses (monophasic ADS or multiple sclerosis [MS]) new deficits.Of 283 children, 244 (86%) required hospitalization for median (interquartile range [IQR]) 6 (3-10) days, 184 had moderate...
Summary: Midazolam, a potent short-acting benzodiazepine, is safe and highly effective agent for the control of status epilepticus. Its efficacy in neonatal seizures, however, has not been determined. Six neonates (aged 1-9 days; gestation, 30-41 weeks) developed seizures from variety causes. In each case, persisted > 12 h despite high-dose phenobarbital therapy with or without addition phenytoin. Midazolam was then administered by continuous intravenous infusion (0.1-0.4 mg/kg/h) 1 to 3...
Aim To identify characteristics of young children with cerebral palsy (CP), and intrinsic extrinsic factors, that may be associated parental perceptions regarding family‐centred health care services. Method We conducted a cross‐sectional study, drawing our sample from the Canadian Cerebral Palsy Registry (CCPR). Parents rated extent provided by their child's teams using 56‐item Measures Process Care (MPOC) questionnaire. Environmental CP phenotypic variables were extracted CCPR for group...
<h3>Objective</h3> To validate a case definition of multiple sclerosis (MS) in the pediatric population using administrative (health claims) data, and to estimate incidence prevalence MS for Ontario, Canada. <h3>Methods</h3> We used population-based data identify persons aged ≤18 years with MS. assessed performance definitions clinical reference cohort including children MS, monophasic demyelinating syndromes, healthy children; we report sensitivity, specificity, positive predictive value...
Abstract COX 20/ FAM 36A encodes a mitochondrial complex IV assembly factor important for 2 activation. Only one homozygous 20 missense mutation has been previously described in two separate consanguineous families. We report four subjects with features that include childhood hypotonia, areflexia, ataxia, dysarthria, dystonia, and sensory neuropathy. Exome sequencing all identified the same novel variants. One variant affected splice donor site of intron‐one (c.41A>G), while other...
This study looks at what profile can be expected in children with cerebral palsy spectrum disorder (CP) and a normal MRI.The data were excerpted from the Canadian Cerebral Palsy Registry database. Only patients who had undergone MRI included analysis. Neuroimaging classification was ascertained by university-based pediatric neuroradiologists split into 2 categories: abnormal MRIs. Six factors then compared between those groups: prematurity, perinatal adversity, presence of more than 1...
To assess the stability of Gross Motor Functional Classification System (GMFCS) in children with cerebral palsy (CP) from time preliminary diagnosis (~2 years age) to (~5 age), and examine factors associated reclassification.We conducted a longitudinal study using sample Canadian CP Registry. Stability was analysed by percentage agreement between timepoints weighted prevalence bias adjusted kappa statistic. Univariate multivariate logistic regressions were performed identify variables...
Summary: Purpose: The emergence of visual field defects attributed to vigabatrin (VGB) treatment and intramyelinic edema in animal experiments has raised concerns about its future role the childhood seizures. Methods: We evaluated our experience with this antiepileptic agent retrospective analysis database chart audit. Results: Of 73 patients, 43 girls 33 boys were treated VGB over a 7‐year period. mean age patients at introduction was 87 months (range, 5–257 months). In 12 cases, used as...
To specifically report on ataxic-hypotonic cerebral palsy (CP) using registry data and to directly compare its features with other CP subtypes.Data prenatal, perinatal, neonatal characteristics gross motor function (Gross Motor Function Classification System [GMFCS]) comorbidities in 35 children were extracted from the Canadian Cerebral Palsy Registry compared 1,804 patients subtypes of CP.Perinatal adversity was detected significantly more frequently (odds ratio [OR] 4.3, 95% confidence...