A5024544618- Medical Device Sterilization and Disinfection
- Infection Control in Healthcare
- Clostridium difficile and Clostridium perfringens research
- Safe Handling of Antineoplastic Drugs
- Healthcare and Environmental Waste Management
- Bacterial Identification and Susceptibility Testing
- Syphilis Diagnosis and Treatment
- Reproductive tract infections research
- Antimicrobial Resistance in Staphylococcus
- Viral gastroenteritis research and epidemiology
- Quality and Safety in Healthcare
- Gut microbiota and health
- Streptococcal Infections and Treatments
- Microscopic Colitis
- Infection Control and Ventilation
- Healthcare cost, quality, practices
- Microbial infections and disease research
- Infective Endocarditis Diagnosis and Management
- Mycobacterium research and diagnosis
- Food composition and properties
- Antibiotic Resistance in Bacteria
- Urinary Tract Infections Management
- Nosocomial Infections in ICU
- Neonatal and Maternal Infections
- Monoclonal and Polyclonal Antibodies Research
University of Manitoba
2013-2022
New York Proton Center
2022
Communities In Schools of Orange County
2022
Ann Arbor Center for Independent Living
2022
University of Richmond
2022
Oregon Medical Research Center
2022
Lindsay Unified School District
2022
Manhattan Institute for Policy Research
2022
University of Pittsburgh
2022
St. Boniface Hospital
2010-2019
Immune-mediated inflammatory disease (IMID) represents a substantial health concern. It is widely recognized that IMID patients are at higher risk for developing secondary inflammation-related conditions. While an ambiguous etiology common to all IMIDs, in recent years, considerable knowledge has emerged regarding the plausible role of gut microbiome IMIDs. This study used 16S rRNA gene amplicon sequencing compare microbiota with Crohn's (CD; N = 20), ulcerative colitis (UC; 19), multiple...
ABSTRACT A panel of 24 methicillin-resistant Staphylococcus aureus strains was distributed to 15 laboratories in Canada evaluate their in-house pulsed-field gel electrophoresis (PFGE) protocols and interpretation criteria. Attempts compare fingerprint images using computer-aided analysis were not successful due variability individual laboratory PFGE protocols. In addition, site the patterns inadequate, as 7 13 sites (54%) made at least one error interpreting fingerprints from panel. 2-day...
ABSTRACT Clostridium difficile -associated diarrhea (CAD) is a very common nosocomial infection that contributes significantly to patient morbidity and mortality as well the cost of hospitalization. Previously, strains toxin A-negative, B-positive C. were not thought be associated with clinically significant disease. This study reports characterization strain was responsible for recently described outbreak CAD. Analysis seven isolates from by pulsed-field gel electrophoresis indicated this...
ABSTRACT Matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) mass spectrometry represents a revolution in the rapid identification bacterial and fungal pathogens clinical microbiology laboratory. Recently, MALDI-TOF has been applied directly to positive blood culture bottles for pathogens, leading reductions turnaround time potentially beneficial patient impacts. The development commercially available extraction kit (Bruker Sepsityper) use with Bruker MALDI BioTyper...
The elderly often have a diet lacking resistant starch (RS) which is thought to lead gut microbiome dysbiosis that may result in deterioration of colonocytes.The primary objective was assess if (ELD; ≥ 70 years age) had compared mid-age (MID; 30-50 adults and then determine the impact daily consumption MSPrebiotic® (a RS) or placebo over 3 months on composition. Secondary objectives included assessment stool short-chain fatty acids (SCFA) inflammatory markers ELD MID Canadian adults.This...
Abstract Objective: To review experience with methicillin -resistant Staphylococcus aureus (MRSA) in tertiary acute-care teaching hospitals on the Canadian prairies. Design: Retrospective for a 36-month period, 1990 through 1992. Setting: Five three prairie provinces. Methods: MRSA isolates and susceptibility were identified clinical microbiology laboratory at each institution. For patient, data collected included duration of institutional residence prior to isolation, patient ethnic...
Phenotypic and genotypic methods were used to characterize extended-spectrum-beta-lactamase (ESBL)-producing Escherichia coli isolated in 2007 from 11 different Canadian medical centers. Of the 209 ESBL-producing E. isolates tested, 148 (71%) produced CTX-M-15, 17 (8%) CTX-M-14, 5 (2%) CTX-M-3, 1 CTX-M-27. Overall, 96 (46%) of ESBL producers belonged clonal complex ST131, with highest prevalence Brampton, Calgary, Winnipeg. ST131 is an important cause community onset urinary tract infections...
The performance of a standard gas sterilizer, which uses mixture 12% ethylene oxide (EtO) and 88% chlorofluorocarbon as the sterilizing (12/88), was compared to selected gas, ion plasma, vaporized hydrogen peroxide (H2O2) sterilizers that do not use chlorofluorocarbons. effect serum salt on sterilizer evaluated.Test carriers (porcelain stainless steel penicylinders, or 125-cm lengths plastic tubing [internal diameter 3.2 mm]) were inoculated with Escherichia coli, Enterococcus faecalis,...
Urinary tract infection (UTI) is common among patients with spinal cord injury. The optimal duration of treatment for symptomatic UTI has not been determined.A randomized, double-blind, placebo-controlled trial compared 3-day and 14-day regimens ciprofloxacin, 250 mg twice daily, the acute in Patients pyelonephritis, struvite stones, hydronephrosis, or long-term indwelling catheters were excluded from trial.Sixty injury enrolled trial, 30 assigned to each study arm. most infecting organisms...
Abstract Reported in this study is the successful incorporation of a hydrophilic antibiotic drug, tetracycline hydrochloride (TCH), into electrospun PEG–PLA nanofibrous membrane without loss its bioactivity. Degradation behavior copolymer was studied vitro . Release TCH from and antimicrobial effects TCH‐loaded against Staphylococcus aureus culture were investigated. The medicated demonstrated sustained release over 6 days found to be effective inhibiting growth S. In addition, increasing...
Abstract Background The increased severity of disease associated with the NAP1 strain Clostridium difficile has been attributed to mutations tcdC gene which codes for a negative regulator toxin production. To assess role hyper-production Toxins A and B in clinical isolates , two NAP1-related five non-related strains were compared. Methods Sequencing was performed on tcdR tcdE determine if there differences that might account Toxin strains. Biological activity evaluated using HFF cell CPE...
Documenting effective approaches to eliminate environmental reservoirs and reduce the spread of hospital-acquired infections (HAIs) has been difficult. This was a prospective study determine if hospital-wide implementation disinfectant cleaner in disposable wipe system replace alone could HAIs over 1 year when housekeeping compliance ≥80%.In this interrupted time series study, ready-to-use accelerated hydrogen peroxide container (DCW) used once per day for all high-touch surfaces patient...
Biofilm contributes significantly to bacterial persistence in endoscope channels. Enhanced cleaning methods capable of removing biofilm from all channels are required decrease infection risk patients. This head-to-head study compared cyclic build-up removal an automated channel cleaner (AECC) with standard manual according instructions for use (IFU) polytetrafluorethylene