A5031000915- Cardiac electrophysiology and arrhythmias
- Mitochondrial Function and Pathology
- Cardiovascular Function and Risk Factors
- Protein Kinase Regulation and GTPase Signaling
- Cardiac Ischemia and Reperfusion
- Ion channel regulation and function
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Receptor Mechanisms and Signaling
- Heart Failure Treatment and Management
- Cardiomyopathy and Myosin Studies
- Fatty Acid Research and Health
- Cardiac Fibrosis and Remodeling
- Nitric Oxide and Endothelin Effects
- Metabolomics and Mass Spectrometry Studies
- Biochemical effects in animals
- Metabolism, Diabetes, and Cancer
- Gestational Diabetes Research and Management
- Nutritional Studies and Diet
- Diet, Metabolism, and Disease
- Cardiac Arrest and Resuscitation
- Antioxidant Activity and Oxidative Stress
- Polyamine Metabolism and Applications
- Diabetic Foot Ulcer Assessment and Management
St. Boniface Hospital
2016-2025
Clinical Research Institute
2016-2024
Research Manitoba
2012-2024
University of Manitoba
2006-2021
Research Canada
2020
Mitsubishi Chemical Holdings (Japan)
2016
Mitsubishi Corporation (United States)
2016
Hospital Research Foundation
2015
Heart and Stroke Foundation
2007
Government of Manitoba
2007
1. Smoking exerts an inflammatory stimulus on lung macrophages, and smokers generally have low intakes of antioxidant micronutrients. This study was performed to investigate the relationship between whole-blood tumour necrosis factor production, plasma interleukin-6 acute-phase protein concentration vitamins in non-smokers. 2. Measurement conducted whole blood stimulated with endotoxin (lipopolysaccharide), concentrations were measured Enzyme dietary proteins determined two groups. 3. Tumour...
The elderly often have a diet lacking resistant starch (RS) which is thought to lead gut microbiome dysbiosis that may result in deterioration of colonocytes.The primary objective was assess if (ELD; ≥ 70 years age) had compared mid-age (MID; 30-50 adults and then determine the impact daily consumption MSPrebiotic® (a RS) or placebo over 3 months on composition. Secondary objectives included assessment stool short-chain fatty acids (SCFA) inflammatory markers ELD MID Canadian adults.This...
The blood pressure lowering effect of a pea protein hydrolysate (PPH) that contained <3 kDa peptides, isolated by membrane ultrafiltration from the thermolysin digest isolate (PPI), was examined using different rat models hypertension as well hypertensive human subjects. PPH showed weak in vitro activities against renin and angiotensin converting enzyme (ACE) with inhibitory 17 19%, respectively, at 1 mg/mL test concentration. Oral administration to spontaneously rats (SHR) doses 100 200...
The objective of this research is to use metabolomic techniques discover and validate plasma metabolite biomarkers for the diagnosis early-stage non-small cell lung cancer (NSCLC). study included samples from 156 patients with biopsy-confirmed NSCLC along age gender-matched 60 healthy controls. A fully quantitative targeted mass spectrometry (MS) analysis (targeting 138 metabolites) was performed on all samples. sample set split into a discovery validation set. Metabolite concentration data,...
Alterations in general characteristics and morphology of the heart, as well changes hemodynamics, myosin heavy chain isoforms, β-adrenoceptor responsiveness, were determined Sprague-Dawley rats at 1, 2, 4, 8, 16 wk after aortocaval fistula (shunt) was induced by needle technique. Three stages cardiac hypertrophy due to volume overload recognized during 16-wk period. Developing occurred within first 2 shunt characterized a rapid increase mass both left right ventricles. Compensated between 8...
Background —Large transmural myocardial infarction (MI) leads to maladaptive cardiac remodeling and places patients at increased risk of congestive heart failure. Angiotensin II, endothelin, α 1 -adrenergic receptor agonists are implicated in the development hypertrophy, interstitial fibrosis, failure after MI. Because these coupled activate G qα protein heart, aim present study was investigate expression function Methods Results —MI produced rats by ligation left coronary artery,...
An adverse environmental experience of the growing fetus may lead to permanent changes in structure and function organs that predispose individual chronic diseases later life; however, nothing is known about occurrence mechanisms heart failure. We employed a rat model which pregnant dams were fed diets containing either 180 g (normal) or 90 (low) casein/kg for 2 weeks before mating throughout pregnancy. The ejection fraction (EF) pups exposed low-protein (LP) diet was severely depressed...
Delayed reperfusion of the ischemic heart (I/R) is known to impair recovery cardiac function and produce a wide variety myocardial defects including ultrastructural damage, metabolic alterations, subcellular Ca2+-handling abnormalities, activation proteases changes in gene expression. Although I/R-injury has been reported induce formation reactive oxygen species (ROS), inflammation intracellular Ca2+-overload, generation oxidative stress considered play critical role development dysfunction....
Lung cancer remains the leading cause of cancer-related mortality worldwide, with early detection critical for improving survival rates, yet conventional methods like CT scans often yield high false-positive rates. This study introduces M-GNN, a Graph Neural Network framework leveraging GraphSAGE, to enhance lung through metabolomics. We constructed heterogeneous graph integrating metabolomics data from 800 plasma samples (586 cases, 214 controls) demographic features and Human Metabolome...
Background: Several mitochondrial abnormalities such as defective energy production, depletion of stores, Ca2+-accumulation, generation reactive oxygen species and impaired intracellular signaling are associated with cardiac dysfunction during the development different heart diseases. Methods: A narrative review was compiled by a search for applicable literature in MEDLINE via PubMed. Results: Mitochondria generate ATP through processes electron transport oxidative phosphorylation, which is...