A5068457996- Antibiotics Pharmacokinetics and Efficacy
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- Antibiotic Use and Resistance
- Venous Thromboembolism Diagnosis and Management
- Surgical site infection prevention
- Clostridium difficile and Clostridium perfringens research
- Blood transfusion and management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Heparin-Induced Thrombocytopenia and Thrombosis
- Poisoning and overdose treatments
- Nosocomial Infections in ICU
- Anesthesia and Pain Management
- Elasticity and Material Modeling
- Pharmaceutical Practices and Patient Outcomes
- Metabolism and Genetic Disorders
- Anesthesia and Sedative Agents
- Orthopedic Infections and Treatments
- Drug Transport and Resistance Mechanisms
- Potassium and Related Disorders
- Infective Endocarditis Diagnosis and Management
University of Manitoba
2016-2025
St. Boniface Hospital
2013-2025
Research Manitoba
2012-2020
Ohio Northern University
2005
American Pharmacists Association
2005
Pharmacodynamic investigations with antimicrobials define the relationship between infecting organism and achievable drug concentrations clinical outcome.To examine this for meropenem in a population of patients who are at high risk infection-related morbidity mortality.The study was retrospective analysis multicenter, randomized, blinded trial. A population-based predictive model created using data from adults febrile neutropenia nonparametric modeling program, NPEM. Patient age, body...
Introduction and Objective: Cefazolin-induced encephalopathy seizures are possibly related to excessive dosing; especially in those with renal dysfunction. This report aims highlight the importance of dose adjustments cefazolin patients diminished function. Case Presentation: An 87-year-old female a history cognitive impairment, remote cerebellar infarcts, hypertension, hypothyroidism presented acute delirium associated urinary tract infection. Her condition worsened she was found have...
ABSTRACT The objective of this study was to characterize the relationship between gentamicin concentrations during surgery and development wound infection following colorectal operations. Despite decades research in surgical prophylaxis, intraoperative antibiotic postoperative required for effective prophylaxis have not been established. A pharmacodynamic analysis conducted using data from a previous prospective, randomized, double-blind clinical which compared two dosage regimens plus...
A population pharmacokinetic model of cefepime was constructed from data adult critical care patients with ventilator-associated pneumonia (VAP). total 32 treated high-dose cefepime, 2 g every 8 h (3-h infusion) or a renal function-adjusted equivalent dose, were randomized into two groups--26 for the initial and 6 validation. Serum samples collected at steady state. Nonparametric adaptive grid modeling employed using two-compartment K(slope) relating elimination rate constant (K(10)) to...
<b>Background:</b> Whether the enteric absorption of neuraminidase inhibitor oseltamivir is impaired in critically ill patients unknown. We documented pharmacokinetic profile admitted to intensive care units (ICUs) with suspected or confirmed pandemic (H1N1) influenza. <b>Methods:</b> included 41 18 years age and older influenza who were for ventilatory support nine ICUs three cities Canada Spain. Using tandem mass spectrometry, we assessed plasma levels free base its active metabolite...
Given concerns regarding optimal therapy for serious Gram-negative infections, the goal was to characterize pharmacodynamics of ciprofloxacin in context treating bloodstream infection.Data were collected from medical records 178 clinical cases. Blood isolates retrieved and MICs measured. Forty-two cases which initiated within 24 h positive blood culture used pharmacodynamic analysis.Significant factors with regard treatment failure low AUC(24)/MIC (P < 0.0001), high MIC = 0.001), male sex...
To describe the mechanism and risk factors for development of aminoglycoside-induced vestibular injury discuss their implications therapeutic monitoring aminoglycoside antibiotics.A MEDLINE search (1975-January 2008) was performed to identify literature on associated with this outcome impact drug monitoring. Additional references were identified through review bibliographies articles.Data mechanisms toxicity its in association exposure extracted from references.The leading irreversible...
Background Information related to the microbiology of peritonitis is critical optimal management patients receiving peritoneal dialysis (PD). The goal was characterize microbiological etiology and antimicrobial susceptibilities PD-related (PDRP) from 2005 2014, inclusive. Methods distribution organisms in culture-positive PDRP described for new episodes relapse infections, further detailed monomicrobial polymicrobial peritonitis. Annual overall rates were also characterized. Antimicrobial...
Carfentanil and related fentanyl analogs have been linked to a number of overdose deaths from drug users in several cities across North America. Diagnosis carfentanil exposure requires very high index clinical suspicion, especially because available laboratory narcotic screens do not detect this agent. We describe 34‐year‐old man admitted with depressed level consciousness respiratory failure after recreational white powder later inferred contain carfentanil. Urine whole blood samples were...
ObjectivesTo evaluate, using Monte Carlo simulation, the pharmacodynamics (PD) of empirical antibiotic monotherapies for serious infections consistent with Canadian intensive care unit (ICU) surveillance data.
Background. Although recent consensus guidelines proposed more aggressive vancomycin troughs of >10 or 15–20 mg/L for complicated Staphylococcus aureus infections, dosing information to achieve these targets in patients undergoing hemodialysis (HD) is scarce.
In the treatment of acute coronary syndromes, reduction sympathetic stress and catecholamine release is an important therapeutic goal. One method used to achieve this goal pain through systemic administration analgesia. Historically, morphine has been analgesic choice in ischemic cardiac pain. This randomized double-blind controlled trial seeks prove utility fentanyl as alternate first-line for ischemic-type chest prehospital setting. Successive patients who were treated suspected emergency...