A5048766617- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Urinary Tract Infections Management
- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- Influenza Virus Research Studies
- Respiratory viral infections research
- Infective Endocarditis Diagnosis and Management
- Bacterial Infections and Vaccines
- Nosocomial Infections in ICU
- Reproductive tract infections research
- Clostridium difficile and Clostridium perfringens research
- Viral Infections and Vectors
- Pharmaceutical and Antibiotic Environmental Impacts
- Antifungal resistance and susceptibility
- Viral gastroenteritis research and epidemiology
- Bartonella species infections research
- Enterobacteriaceae and Cronobacter Research
- Escherichia coli research studies
- SARS-CoV-2 and COVID-19 Research
- Syphilis Diagnosis and Treatment
- Rabies epidemiology and control
University of Manitoba
2016-2025
St. Boniface Hospital
2014-2025
Manitoba Health
2018-2023
Diagnostic Services Manitoba
2010-2022
Health Sciences Centre
2006-2022
Management Support Technology (United States)
2017
Nova Scotia Health Authority
2016
Izaak Walton Killam Health Centre
2016
Dalhousie University
2016
Vancouver General Hospital
2016
ABSTRACT Between 1 September 2005 and 30 June 2006, 19 medical centers collected 4,180 isolates recovered from clinical specimens patients in intensive care units (ICUs) Canada. The were 2,292 respiratory (54.8%), 738 blood (17.7%), 581 wound/tissue (13.9%), 569 urinary (13.6%). 10 most common organisms isolated 79.5% of all methicillin-susceptible Staphylococcus aureus (MSSA) (16.4%), Escherichia coli (12.8%), Pseudomonas aeruginosa (10.0%), Haemophilus influenzae (7.9%), coagulase-negative...
ABSTRACT Matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) mass spectrometry represents a revolution in the rapid identification bacterial and fungal pathogens clinical microbiology laboratory. Recently, MALDI-TOF has been applied directly to positive blood culture bottles for pathogens, leading reductions turnaround time potentially beneficial patient impacts. The development commercially available extraction kit (Bruker Sepsityper) use with Bruker MALDI BioTyper...
ABSTRACT A total of 5,282 bacterial isolates obtained between 1 January and 31 December 2008, inclusive, from patients in 10 hospitals across Canada as part the Canadian Ward Surveillance Study (CANWARD 2008) underwent susceptibility testing. The most common organisms, representing 78.8% all clinical specimens, were follows: Escherichia coli (21.4%), methicillin-susceptible Staphylococcus aureus (MSSA; 13.9%), Streptococcus pneumoniae (10.3%), Pseudomonas aeruginosa (7.1%), Klebsiella...
The purpose of the CANWARD study was to assess antimicrobial activity a variety available agents against 22 746 pathogens isolated from patients in Canadian hospitals between 2007 and 2011. Between 2011, 27 123 were collected tertiary-care centres across Canada; underwent susceptibility testing using CLSI broth microdilution methods. Patient demographic data also collected. Of isolates collected, 45.2%, 29.6%, 14.8% 10.4% blood, respiratory, urine wound specimens, respectively. demographics...
ObjectivesTo assess the proportion of Escherichia coli and Klebsiella pneumoniae from Canadian hospitals that produce extended-spectrum β-lactamases (ESBLs), AmpC carbapenemases, as well to describe patterns antibiotic resistance molecular characteristics these organisms.
From January 2007 to December 2009, an annual Canadian national surveillance study (CANWARD) tested 2,943 urinary culture pathogens for antimicrobial susceptibilities according Clinical and Laboratory Standards Institute guidelines. The most frequently isolated were as follows (number of isolates, percentage all isolates): Escherichia coli (1,581, 54%), enterococci (410, 14%), Klebsiella pneumoniae (274, 9%), Proteus mirabilis (122, 4%), Pseudomonas aeruginosa (100, 3%), Staphylococcus...
Plazomicin is a next-generation aminoglycoside that not affected by most clinically relevant aminoglycoside-modifying enzymes. The in vitro activities of plazomicin and comparator antimicrobials were evaluated against collection 5,015 bacterial isolates obtained from patients Canadian hospitals between January 2011 October 2012. Susceptibility testing was performed using the Clinical Laboratory Standards Institute (CLSI) broth microdilution method, with MICs interpreted according to CLSI...
Testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) relies on reverse transcription polymerase chain reaction (RT-PCR), which amplifies SARS-CoV-2 genetic material.[1][1] Nasopharyngeal or oropharyngeal RT-PCR sensitivity is highest when performed early after symptom onset.[2][2
The novel non-β-lactam β-lactamase inhibitor NXL104, in combination with cefepime, ceftazidime, ceftriaxone, amdinocillin, and meropenem, was tested against 190 extended-spectrum (ESBL)-producing Escherichia coli Klebsiella pneumoniae isolates, 94 AmpC-hyperproducing E. 8 AmpC/ESBL-coexpressing isolates. NXL104 restored 100% susceptibility to the partner cephalosporins for all isolates tested. Amdinocillin meropenem MICs were modestly improved (2 32 times lower) by NXL104. These results...
Abstract Objectives The CANWARD surveillance study was established in 2007 to annually assess the vitro susceptibilities of a variety antimicrobial agents against bacterial pathogens isolated from patients receiving care Canadian hospitals. Methods 42 936 were received and CLSI broth microdilution testing performed on 37 355 isolates. Limited patient demographic data submitted with each isolate collated analysed. Results Of isolates tested, 43.5%, 33.1%, 13.2% 10.2% blood, respiratory, urine...