A5052730446- Respiratory viral infections research
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Advanced Fiber Optic Sensors
- Underwater Acoustics Research
- Inertial Sensor and Navigation
- Underwater Vehicles and Communication Systems
- Bacterial Infections and Vaccines
- Electromagnetic Compatibility and Noise Suppression
- Lung Cancer Research Studies
- Speech and Audio Processing
- Immunodeficiency and Autoimmune Disorders
- Geophysics and Sensor Technology
- Silicone and Siloxane Chemistry
- Advancements in PLL and VCO Technologies
- Target Tracking and Data Fusion in Sensor Networks
- Semiconductor Lasers and Optical Devices
- Optical Network Technologies
- Advanced Fiber Laser Technologies
- Advanced Thermoelectric Materials and Devices
- Cancer Immunotherapy and Biomarkers
- Surface Modification and Superhydrophobicity
- Indoor and Outdoor Localization Technologies
- Pneumocystis jirovecii pneumonia detection and treatment
- Electromagnetic Compatibility and Measurements
Dalhousie University
2016-2025
Zhejiang University
2013-2025
Shanghai Pulmonary Hospital
2020-2024
Tongji University
2020-2024
Izaak Walton Killam Health Centre
2016-2024
Dongguan University of Technology
2015-2024
Communication University of Zhejiang
2024
Hengyang Normal University
2023
Nova Scotia Health Authority
2016-2023
Hangzhou Medical College
2022-2023
Influenza is an important cause of morbidity and mortality among older adults. Even so, effectiveness influenza vaccine for adults has been reported to be lower than younger adults, the impact frailty on (VE) outcomes uncertain. We aimed study VE against hospitalization in focusing frailty.We report trivalent (TIV) people ≥65 years age hospitalized during 2011-2012 season using a multicenter, prospective, test-negative case-control design. A validated index (FI) was used measure...
Immunization of pregnant women with tetanus-diphtheria-acellular pertussis vaccine (Tdap) provides protection against to the newborn infant.In a randomized, controlled, observer-blind, multicenter clinical trial, we measured safety and immunogenicity Tdap during pregnancy effect on infant's immune response primary vaccination at 2, 4, 6 months booster 12 age. A total 273 received either or tetanus-diphtheria (Td) in third trimester provided information for analysis samples analyses; 261...
Fibronectin, an extracellular matrix protein, has been reported to be associated with heterogeneous cancer stemness, angiogenesis and progression in multiple types. However, the roles underlying mechanism of fibronectin on NSCLC need further elucidated.Public dataset such as Kaplan-Meier Plotter was used determine prognostic significance genes. The correlation different protein expression clinical xenograft tissues tested by immunohistochemistry experiment. Both vitro vivo experiments were...
Several studies have shown that combination treatment with natural products and chemotherapy agents can improve the sensitivity cytotoxicity of agents. Resveratrol, a product, has many biological effects including antitumor antiviral activities, as well vascular protective effect. The aim this study is to investigate synergistic anticancer effect resveratrol in cisplatin potential mechanisms involved A549 cells. results obtained from Cell Counting Kit-8 isobolographic analysis demonstrated...
Respiratory syncytial virus infection can cause lower respiratory tract in older adults comparable to influenza, but no vaccines are available.
Lung cancer is the most common cause of cancer-related death globally. There are several reasons for this high mortality rate, including metastasis to multiple organs, especially brain. Exosomes play a pivotal role in tumor by remodeling microenvironment remote target organs and promoting pre-metastatic niche's formation. Since astrocytes indispensable maintaining homeostasis brain microenvironment, it's great interest explore influence lung cell-derived exosomes on further understand...
Respiratory syncytial virus (RSV) disease in older adults is undercharacterized. To help inform future immunization policies, this study aimed to describe the burden Canadian aged ≥50 years hospitalized with RSV.Using administrative data and nasopharyngeal swabs collected from active surveillance among an acute respiratory illness (ARI) during 2012-2013, 2013-2014, 2014-2015 influenza seasons, RSV was identified using a multiplex polymerase chain reaction test associated burden, incidence,...
From 2002 to 2023, palivizumab was the only intervention reduce respiratory syncytial virus (RSV)-associated hospitalizations in high-risk infants Canada but advances RSV prevention are drastically changing this landscape. Eligibility criteria for monoclonal antibody preterm varied over time across each of 10 Canadian provinces and 3 territories. The National Professional Pediatric Association (Canadian Society) revised its eligibility recommendations 2015, removing access 30 32 weeks...
High-efficiency electromagnetic transducers are crucial for enabling the self-sustained operation of underwater sound sources under power-constrained conditions as noted by Hao, Xie, and Ma [Proceedings 2019 Western China Acoustics Academic Conference, Guangzhou, (November 5-9, 2019)]. This paper proposes a permanent magnet drive technology to enhance electromechanical conversion efficiency can-type low-power driving conditions. The consist coils, an armature, cylindrical magnetic core with...
A high-sensitivity demodulation method for the vibration-induced frequency shift of an optoelectronic oscillator (OEO) using acousto-optic modulator (AOM) has been proposed and experimentally demonstrated. This is achieved by separating optical carrier (OC) first-order sideband, directing them into reference sensing arms a Michelson interferometer (MI), respectively. Additionally, since system sensitivity depends on rather than oscillating frequency, vibration can be at OEO frequencies as...
Immune therapy has shown good results in small-cell lung cancer (SCLC), but the impact of immune microenvironment disease is unclear. In this work, we detected expression programmed death 1 (PD-1), PD-ligand (PD-L1), and other biomarkers cancer. We also analyzed correlations between these markers survival SCLC.Protein PD-1, PD-L1, PD-L2, CD3, CD4, CD8, FOXP3 was surgical tissues from 102 SCLC patients by immunohistochemistry.Positive PD-1 on tumor-infiltrating lymphocytes (TILs) found 40.2%...
The 13-valent pneumococcal conjugate vaccine (PCV13) was recently shown to be effective against PCV13-type invasive disease (IPD) and community acquired pneumonia (CAPSpn) in healthy adults aged ≥65 years, prompting many countries re-assess adult immunization. In Canada, the potential benefits of PCV13 immunization were unclear given anticipated herd immunity from childhood introduced since 2010. This study describes serotype distribution clinical outcomes Canadian ≥16 who hospitalized with...
Non-small cell lung cancer comprises the majority of cases and is insensitive to chemotherapy. Most patients develop drug resistance. Recently, tetrandrine (TET), a bis-benzylisoquinoline alkaloid, was identified as novel anti-cancer agent. However, effect combined with cisplatin on has not yet been studied. We aimed identify possible synergistic between cisplatin, besides, investigate effects TET in combination DDP proliferation apoptosis cisplatin-resistant cisplatin-sensitive A549 lines,...
Pneumococcal community acquired pneumonia (CAPSpn) and invasive pneumococcal disease (IPD) cause significant morbidity mortality worldwide. Although childhood immunization programs have reduced the overall burden of disease, there is insufficient data in Canada to inform policy immunocompetent adults. This study aimed describe clinical outcomes hospitalized Canadian adults, determine proportion cases caused by vaccine-preventable serotypes.Active surveillance for CAPSpn IPD adults was...
Background Consideration of cost determinants is crucial to inform delivery public vaccination programs. Objectives To estimate the average total laboratory‐confirmed influenza requiring hospitalization in Canadians prior to, during, and 30 days following discharge. analyze effects patient/disease characteristics, treatment, regional differences costs. Methods Study utilized previously recorded clinical resource use, outcomes patients admitted hospitals Serious Outcomes Surveillance ( SOS ),...
Background: The further progression of credible expression profiling analysis genes continues to expand our understanding the biological characteristics in lung cancer. In this study, RNA sequencing (RNA-Seq) was used contrast transcriptomics small cell cancer (SCLC) that acquired partial response (PR) and stable disease (SD)/progressive (PD) after first-line chemotherapy. We aimed illuminate underlying mechanisms long noncoding RNAs (lncRNAs) microRNAs (miRNAs) efficacy SCLC Methods: Six...
Background In Canada, 13-valent pneumococcal conjugate vaccine (PCV13) is recommended in childhood, individuals at high risk of invasive disease (IPD) and healthy adults aged ≥65 years for protection against vaccine-type IPD community-acquired pneumonia (pCAP). Since recommendations Canada include both age-based risk-based guidance, this study aimed to describe the burden vaccine-preventable pCAP hospitalised by age. Methods Surveillance (CAP) was performed prospectively from 2010 2015. CAP...