A5039192387- COVID-19 Clinical Research Studies
- Antifungal resistance and susceptibility
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Fungal Infections and Studies
- Hematological disorders and diagnostics
- Sepsis Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Drug-Induced Ocular Toxicity
- Cervical Cancer and HPV Research
- Antibiotic Use and Resistance
- Viral gastroenteritis research and epidemiology
- Oral Health Pathology and Treatment
- Virus-based gene therapy research
- Dermatological and COVID-19 studies
- Cardiac Arrest and Resuscitation
- Microscopic Colitis
- Influenza Virus Research Studies
- Nail Diseases and Treatments
- Histiocytic Disorders and Treatments
- Pericarditis and Cardiac Tamponade
- Drug-Induced Adverse Reactions
- SARS-CoV-2 detection and testing
- Clostridium difficile and Clostridium perfringens research
- Colorectal and Anal Carcinomas
Hospitales Regionales de Alta Especialidad
2020-2024
Instituto Tecnológico de Oaxaca
2021-2022
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2013-2014
Mexican Social Security Institute
2006
Abstract Background Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aimed estimate the effects of hydroxychloroquine and chloroquine survival in from all available RCT evidence, published unpublished. Methods: Rapid meta-analysis ongoing, completed, discontinued RCTs treatment for any patients (protocol: https://osf.io/QESV4/ )....
The progressive disseminated histoplasmosis (PDH) has been associated with severe disease and high risk of death among people living HIV (PLWHIV). Therefore, the purpose this multicenter, prospective, double-blinded study done in ten Mexican hospitals was to determine diagnostic accuracy detecting Histoplasma capsulatum antigen urine using IMMY ALPHA EIA kit (IAHE), clarus GM Enzyme Immunoassay (cHGEI IMMY) MiraVista Urine Antigen LFA (MVHUALFA); as well Hcp100 1281-1283220SCAR nested PCRs...
Anal cancer has become one of the most common non-AIDS-defined tumors among Human Immunodeficiency Virus-positive (HIV+) individuals, and a rise in its incidence HIV+ Men who have Sex with (MSM) been shown, despite introduction Highly Active Anti-Retroviral Therapy (HAART). Papillomavirus (HPV) infections are highly prevalent MSM recent studies shown high rates HPV-associated anal intraepithelial neoplasia (AIN) this population. In present study we determined prevalence nature HPV...
We evaluated clinical effectiveness of regdanvimab (CT-P59), a severe acute respiratory syndrome coronavirus 2 neutralizing monoclonal antibody, in reducing disease progression and recovery time patients with mild-to-moderate 2019 (COVID-19), primarily Alpha variant.This was phase 3 2/3 parallel-group, double-blind, randomized trial. Outpatients COVID-19 were to single-dose 40 mg/kg (n = 656) or placebo 659), alongside standard care. The primary endpoint up day 28 among "high-risk" patients....
Background The Histoplasma urine antigen (HUAg) is the preferred method to diagnose progressive disseminated histoplasmosis (PDH) in HIV patients. In 2007, IMMY ALPHA EIA was approved for clinical on-site use, and therefore useful regions outside United States. However, ALPHA-HUAg considered inferior MVista-HUAg which only available on referral. We aim evaluate diagnostic accuracy of ALPHA-HUAg. Methodology/Principal findings conducted a multicenter, prospective, test study two secondary...
The 2009-2010 influenza A (H1N1pdm09) pandemic caused substantial morbidity and mortality among young patients; however, estimates have been confounded by regional differences in eligibility criteria inclusion of selected populations. In 2013-2014, H1N1pdm09 became North America's dominant seasonal strain. Our objective was to compare the baseline characteristics, resources, treatments with outcomes critically ill patients Mexican Canadian hospitals 2014 using consistent...
The novel coronavirus pandemic (COVID-19) represents a major public health problem and it is key to find treatment that reduces mortality. Our objective was estimate whether with 400 mg/day of Hydroxychloroquine for 10 days in-hospital mortality in subjects severe respiratory disease due COVID-19 compared placebo.A double-blind, randomized, placebo-controlled trial evaluate the safety efficacy by through an intention-to-treat analysis. Eligible study were adults aged more than 18 years...
Fusarium species represent an opportunistic fungal pathogen. The data in Mexico about infections humans are scarce. Here, we present a retrospective series of patients with confirmed diagnosis fusariosis eight different hospitals from January 2010 to December 2019. proven was made according the European Organization for Research and Treatment Cancer Mycoses Study Group Education Consortium (EORT/MSG) criteria. A total 49 cases were identified our series. Most had burn injuries (49%), 37%...
Phase III clinical trials have documented the efficacy of SARS-CoV-2 vaccines in preventing symptomatic COVID-19. Nonetheless, it is imperative to continue analyzing response different real-life studies. Our objective was evaluate effectiveness five hospitalized patients with COVID-19 during third outbreak Mexico dominated by Delta variant.A test-negative case-control study performed nine tertiary-care hospitals for We estimated odds ratios (OR) adjusted variables related a priori likelihood...
ABSTRACT The novel coronavirus pandemic (COVID–19) represents a major public health problem due to its rapid spread and ability generate severe pneumonia. Thus, it is essential find treatment that reduces mortality. Our objective was estimate whether with 400 mg/day of Hydroxychloroquine for 10 days in-hospital mortality in subjects respiratory disease COVID-19 compared placebo. Material methods A double-blind, randomized, placebo-controlled trial evaluate the safety efficacy by through an...
Invasive fungal infections (IFIs) affect >1.5 million people per year. Nevertheless, IFIs are usually neglected and underdiagnosed. should be considered as a public-health problem major actions taken to tackle them their associated costs. Aim To report the incidence of in four Mexican hospitals, describe economic cost with therapy impact adverse events such acute kidney injury (AKI), liver damage (LD), ICU stay. This was retrospective, transversal study carried-out hospitals. All occurring...
Abstract Background Regdanvimab is a monoclonal antibody with activity against SARS-CoV-2. A Phase 2/3 study two parts currently ongoing and data up to Day 28 of Part 1 available while the from 1315 patients enrolled in 2 are expected June 2021. Methods This phase 2/3, randomized, parallel-group, placebo-controlled, double-blind aimed assess therapeutic efficacy regdanvimab outpatients mild moderate COVID-19, not requiring supplemental oxygen therapy. Patients aged >18 onset symptoms...
Abstract Objective: This study aims to outline Clostridioides difficile infection (CDI) trends and outcomes in Mexican healthcare facilities during the COVID-19 pandemic. Design: Observational of case series. Setting: Sixteen public hospitals private academic institutions across eight states Mexico from January 2016 December 2022. Patients: CDI patients. Methods: Demographic, clinical, laboratory data patients were obtained clinical records. Cases classified as community or...
In individuals with HIV/AIDS, 47% of the deaths are attributed to invasive fungal infections (IFIs), despite antiretroviral (ARV) therapy. This is a retrospective study carried out in Hospital Regional de Alta Especialidad Oaxaca (HRAEO), southwest Mexico, where IFIs that occurred during 2016⁻2017 described. A total 55 were included. Histoplasmosis (36%) and possible-IFIs neutropenic fever (20%) most frequent cases, followed by cryptococcosis (14%). The HIV/AIDS subpopulation corresponded 26...
Background Men who have sex with men (MSM) been identified as a high-risk group for anal cancer. HPV has found associated this neoplasia it in cervical Concurrent infection HIV may facilitate or accelerate the pathological consequences of infections. In Mexico, where cancer is major public health problem, little known about prevalence and role HIV-positive population MSM. Methods: We analysed 323 exudates from MSM, Clinic at Instituto Nacional de Ciencias Médicas y Nutrición ‘Salvador...
Background Increasing global incidence of serious fungal infections (SFI) requires increasing access to high quality medical mycology education improve their identification and decrease associated mortality. Methods An online course was developed by two infectious diseases (ID) specialists. The aimed diagnosis SFI delivered from April-June 2019. consisted 9 interactive sessions every week. Sessions were streamed a hospital in Mexico local participants gather there Other connected...