A5023797923- HIV-related health complications and treatments
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Gut microbiota and health
- Immune Cell Function and Interaction
- Antifungal resistance and susceptibility
- HIV/AIDS drug development and treatment
- Cardiovascular Health and Disease Prevention
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS oral health manifestations
- Medication Adherence and Compliance
- Fungal Infections and Studies
- Nail Diseases and Treatments
- T-cell and B-cell Immunology
- HIV, Drug Use, Sexual Risk
- Long-Term Effects of COVID-19
- Cytomegalovirus and herpesvirus research
- Microscopic Colitis
- Oral microbiology and periodontitis research
- SARS-CoV-2 and COVID-19 Research
Universidad de Guadalajara
2011-2025
Hospital Civil de Guadalajara
2012-2025
Instituto Nacional de Enfermedades Respiratorias
2017
LN inflammation in chronic HIV is associated with accumulation of follicular CD8 T cells that could be redirected to kill infected cells.
Gut microbiota undergoes profound alterations in alcohol cirrhosis. Microbiota-derived products, e.g., short chain fatty acids (SCFA), regulate the homeostasis of gut-liver axis. The objective was to evaluate composition and functions intestinal patients with alcohol-decompensated Fecal samples 18 healthy controls (HC) were obtained. Microbial characterized by 16S rRNA amplicon sequencing, SCFA quantification performed gas chromatography (GC), metagenomic predictive profiles analyzed...
Abstract Background HIV-infection results in damage and dysfunction of the gastrointestinal system. HIV enteropathy includes pronounced CD4+ T-cell loss, increased intestinal permeability, microbial translocation that promotes systemic immune activation, which is implicated disease progression. A synbiotic combination probiotics prebiotics could improve gut barrier function. Our study goal was to determine whether use a synbiotic, or prebiotic can recover immunological parameters...
The progressive disseminated histoplasmosis (PDH) has been associated with severe disease and high risk of death among people living HIV (PLWHIV). Therefore, the purpose this multicenter, prospective, double-blinded study done in ten Mexican hospitals was to determine diagnostic accuracy detecting Histoplasma capsulatum antigen urine using IMMY ALPHA EIA kit (IAHE), clarus GM Enzyme Immunoassay (cHGEI IMMY) MiraVista Urine Antigen LFA (MVHUALFA); as well Hcp100 1281-1283220SCAR nested PCRs...
Antiretroviral therapies (ART) are strongly associated with weight gain and metabolic syndrome (MetS) development in HIV-infected patients. Few studies have evaluated the association between gut microbiota integrase strand transfer inhibitor (INSTI)-based protease (PI)-based regimens patients MetS. To assess this, fecal samples were obtained from treated different (16 PI + MetS or 30 INSTI MetS) 18 healthy controls (HCs). The microbial composition was characterized using 16S rRNA amplicon...
People Living with HIV (PLWHIV) present an increased risk of developing non-communicable diseases, such as type 2 diabetes (T2D), making it crucial to optimize glycemic control and assess metabolic markers. HbA1c is considered the gold standard for evaluating control, while fructosamine (FA) offers advantages in assessing non-glycemic determinants. Discrepancies between FA are common may be influenced by temporal factors. The Glycation Gap (G-gap) emerges a tool clarify these discrepancies....
Abstract Background The study of stool microbiota has taken great relevance in the last years, given its role maintenance intestinal metabolic, physiological, and immunological homeostasis, as well as, effect over HIV biomarkers levels such CD4/CD8 ratio, high sensitivity C-Reactive Protein (hs-CRP), related to poor outcomes (rapid progression AIDS). Several efforts have been made characterize gut microbiome. In infection, most studies report presence a dysbiotic pattern; however, few them...
Antiretroviral therapies have proved life-saving in HIV infection, dramatically reducing morbidity and mortality.With longer survival, morbidities mortalities infection are increasingly similar to the associated with ageing.In treated risk of these is linked immune activation, inflammation coagulation indices.And persons failure restore circulating CD4 T cell numbers a greater as well heightened levels coagulation.The drivers incompletely defined could be related sustained low viral...
Cardiovascular disease is a major cause of death among people living with HIV (PLH). Non-treated PLH show increased levels inflammation and biomarkers vascular activation, arterial stiffness as prognostic cardiovascular risk factor. We investigated the effect one year ART on treatment-naïve HIV(+) individuals inflammatory cytokines.We cross-sectionally compared aortic via tonometry, inflammatory, serum cytokines (n = 20) (-) 9) matched by age, sex, metabolic profile, Framingham score....
Background The Histoplasma urine antigen (HUAg) is the preferred method to diagnose progressive disseminated histoplasmosis (PDH) in HIV patients. In 2007, IMMY ALPHA EIA was approved for clinical on-site use, and therefore useful regions outside United States. However, ALPHA-HUAg considered inferior MVista-HUAg which only available on referral. We aim evaluate diagnostic accuracy of ALPHA-HUAg. Methodology/Principal findings conducted a multicenter, prospective, test study two secondary...
Background Transmitted drug resistance (TDR) remains an important concern for the management of HIV infection, especially in countries that have recently scaled-up antiretroviral treatment (ART) access. Methodology/Principal Findings We designed a study to assess diversity and transmitted prevalence trends Mexico. 1655 ART-naïve patients from 12 Mexican states were enrolled 2005 2010. TDR was assessed plasma pol sequences using Stanford scores WHO surveillance mutation list. fluctuations...
Abstract Associations between HLA class I alleles and HIV progression in populations exhibiting Amerindian Caucasian genetic admixture remain understudied. Using univariable multivariable analyses we evaluated associations with five clinical parameters 3,213 clade B-infected, ART-naïve individuals from Mexico Central America (MEX/CAM cohort). A Canadian cohort (HOMER, n = 1622) was used for comparison. As expected, allele frequencies MEX/CAM HOMER differed markedly. In MEX/CAM, 13 - , 24 B...
HIV infection results in marked alterations the gut microbiota (GM), such as loss of microbial diversity and different taxonomic metabolic profiles. Despite antiretroviral therapy (ART) partially ablating gastrointestinal alterations, profile after successful new ART has shown wide variations. Our objective was to determine GM composition functions people living with (PLWHIV) under comparison seronegative controls (SC). Fecal samples from 21 subjects (treated integrase strand-transfer...
A remarkable increase in metabolic syndrome (MetS) has occurred HIV-infected subjects. Gut dysbiosis is involved the pathogenesis of disorders. Therefore, aim to explore profile gut microbiota Mexican population with HIV infection and MetS.In all, 30 patients MetS were compared a group without MetS, treated integrase inhibitors undetectable viral load included study. Stool samples analysed by 16S rRNA next-generation sequencing. High-sensitivity C-reactive protein >3 mg L-1 higher scores...
The diagnosis of neurosyphilis is a challenge, and the criteria for deciding when to perform lumbar puncture are still controversial, especially in people living with HIV late latent syphilis diagnosis.Retrospective analysis demographic, clinical, laboratory data documented or unknown duration cerebrospinal fluid VDRL test.122 patients were evaluated, whom 52 had neurosyphilis. Patients without presented similar viral load lymphocyte CD4+ T-cell count. Neurological symptoms (OR 6.4, 95% CI...
BACKGROUND: Chronic periodontitis (CP), caused by bacteria and fungi, appears in up to 66% of HIV-patients. The impact association HIV-treatment (HAART) Candida itself has not been properly evaluated the development progression CP. immunopathogenesis is characterized CD4+ T-cells activation balance between T-helper 1 (Th1) 2 (Th2) or a mixed cytokine profile. Currently, associated causes an immune response HIV-patients with CP controversial. Our aims were determination spp. profile oral...
HIV infection is characterized by CD4+ T-cells depletion related to gut damage, microbial translocation, immune activation and intestinal systemic low-grade inflammation. With the use of antiretroviral treatment, these alterations in HIV+ patients reach similar levels HIV- controls. However, almost 20% have deficient reconstitution T-cells, which make them more susceptible develop non-AIDS AIDS comorbidities.HIV+ on ART, with sustained virologic control were grouped according their as:...
HIV/HCV coinfection is associated with a rapid progression to liver damage. Specifically, NK cell population dysregulation of particular interest, as these cells have been shown block HCV replication effectively and an anti-fibrogenic activity. The NKp30 receptor linked tumor lysis has crucial role during viral infections. In the present study, we determined subpopulations based on CD56 CD16 expression, its isoforms A, B, C, along cytotoxicity molecules in patients HIV/HCV.
HIV pretreatment drug resistance (PDR) to NNRTIs in persons initiating ART is increasing Mexico.
HIV subjects have several kidney pathologies, like HIV-associated nephropathy or antiretroviral therapy injury, among others. The global prevalence of Chronic Kidney Disease (CKD) is 8-16%; however, in subjects, the varies between geographic regions (2-38%). aim was to determine CKD and identify associated risk factors.A longitudinal descriptive study carried out at 'Hospital Civil de Guadalajara' Feb'18 - Jan'19. Basal clinical, demographic, opportunistic infections (OI), laboratory data...
Antiretroviral therapy has increased the life expectancy of people living with HIV. However, this increase is not free comorbidities, and metabolic syndrome one most prevalent. Berberine an alkaloid nutraceutical that been shown to ameliorate disorders such as prediabetes, polycystic ovary syndrome, non-alcoholic fatty liver disease. it tested in HIV infection. Therefore, we conducted a randomized controlled trial evaluate efficacy berberine improving syndrome.In double-blind,...