A5048555759- HIV Research and Treatment
- Immune Cell Function and Interaction
- HIV-related health complications and treatments
- T-cell and B-cell Immunology
- HIV/AIDS Research and Interventions
- Reproductive System and Pregnancy
- Immune cells in cancer
- HIV/AIDS drug development and treatment
- Cytomegalovirus and herpesvirus research
- vaccines and immunoinformatics approaches
- Pneumocystis jirovecii pneumonia detection and treatment
- Inflammation biomarkers and pathways
- Herpesvirus Infections and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Institut Pasteur
2016-2020
National Institute of Infectious Diseases
2017
Instituto Nacional de Enfermedades Respiratorias
2013
Background Myeloid-derived suppressor cells (MDSC) are a functional myeloid cell subset that includes with immune suppressive properties. The presence of MDSC has been reported in the peripheral blood patients several malignant and non-malignant diseases. So far, direct comparison across different diseases Centers is hindered by technical pitfalls lack standardized methodology. To overcome this issue, we formed network through COST Action Mye-EUNITER ( www.mye-euniter.eu ) goal to...
Elevated blood CXCL10/IP-10 levels during primary HIV-1 infection (PHI) were described as an independent marker of rapid disease onset, more robust than peak viremia or CD4 cell nadir. IP-10 enhances the recruitment CXCR3+ cells, which include major HIV-target raising question if it promotes establishment viral reservoirs. We analyzed data from four cohorts HIV+ patients, allowing us to study before (Amsterdam cohort), well controlled and uncontrolled (ANRS cohorts). also addressed...
Abstract HIV-1 causes chronic inflammation and AIDS in humans, whereas related simian immunodeficiency viruses (SIVs) replicate efficiently their natural hosts without causing disease. It is currently unknown to what extent virus-specific properties are responsible for these different clinical outcomes. Here, we incorporate two putative virulence determinants, i.e., a Vpu protein that antagonizes tetherin blocks NF-κB activation Nef fails suppress T cell via downmodulation of CD3, into...
Abstract Associations between HLA class I alleles and HIV progression in populations exhibiting Amerindian Caucasian genetic admixture remain understudied. Using univariable multivariable analyses we evaluated associations with five clinical parameters 3,213 clade B-infected, ART-naïve individuals from Mexico Central America (MEX/CAM cohort). A Canadian cohort (HOMER, n = 1622) was used for comparison. As expected, allele frequencies MEX/CAM HOMER differed markedly. In MEX/CAM, 13 - , 24 B...
Abstract Introduction Combined anti‐retroviral therapy ( cART ) transformed HIV ‐1 from a deadly disease into chronic infection, but does not cure infection. It also fully restore ‐induced gut damage unless administered extremely early after Additional biomarkers are needed to evaluate the capacity of therapies aimed at remission/cure intestinal immune and limit inflammation. Herein, we identify systemic surrogate marker whose levels would reflect such as Th17 cell loss starting primary...
HLA-B35 has consistently been associated with rapid HIV disease progression, particularly alleles of the Px group. As B35 is most prevalent HLA-B in Mexico, we investigated outcome relation to HLA expression a large cohort (n=976) Mexicans. Contrary previous studies, no impact on viral load or CD4 cell count was observed association PY/Px groups. However, differences specific alleles.
ABSTRACT HIV circumvents HLA class I-restricted CD8 + T-cell responses through selection of escape mutations that leave characteristic mutational “footprints,” also known as HLA-associated polymorphisms (HAPs), on sequences at the population level. While many footprints are universal across subtypes and human populations, others can be region specific a result unique immunogenetic background each host population. Using published probabilistic phylogenetically informed model, we compared HAPs...