A5057902443- Diabetes, Cardiovascular Risks, and Lipoproteins
- Global Public Health Policies and Epidemiology
- Liver Disease Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- Long-Term Effects of COVID-19
- Air Quality and Health Impacts
- Metabolism, Diabetes, and Cancer
- Energy and Environment Impacts
- Lipid metabolism and disorders
- COVID-19 Clinical Research Studies
- Health and Lifestyle Studies
- Hormonal Regulation and Hypertension
- Sex and Gender in Healthcare
- Mesenchymal stem cell research
- Cancer, Hypoxia, and Metabolism
- Health disparities and outcomes
- Antioxidant Activity and Oxidative Stress
- Cancer, Lipids, and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Atmospheric chemistry and aerosols
- Nutrition, Genetics, and Disease
- Peroxisome Proliferator-Activated Receptors
- Blood Pressure and Hypertension Studies
- Climate Change and Health Impacts
- Physical Activity and Health
Military University Nueva Granada
2017-2024
Universidad De Santander
2022-2024
Universidad de Santander
2024
Asociación Colombiana de Diabetes
2022
Clínica Santa María
2022
Background: Myokines are a group of protein mediators produced by skeletal muscle under stress or physical exertion. Even though their discovery and effects in cell culture animal models disease have elicited great enthusiasm, very little is known about role human metabolism. We assessed whether plasma concentrations three myokines (myonectin, myostatin fibroblast-derived growth factor 21 [FGF-21]) would be associated with direct indirect indicators insulin resistance (IR) individuals who...
A higher prevalence of hypertension is reported among Afro-descendants compared with other ethnic groups in high-income countries; however, there a paucity information low- and medium-income countries.We evaluated 3,745 adults from 3 (552 White, 2,746 Mestizos, 447 Afro-descendants) enrolled the prospective population-based cohort study (PURE)-Colombia. We assessed associations between anthropometric, socioeconomic, behavioral factors, hypertension.The overall was 39.2% (46.3%) than Mestizos...
ABSTRACT Purpose This study aimed to investigate longitudinal associations between physical activity levels and obesity in adults Colombia, where participation large amounts of light-intensity is a necessity for many people. Methods Participation moderate- vigorous-intensity was assessed from 2005 2009, 2011 2019 men women the Prospective Urban Rural Epidemiology (PURE) study. Total level categorized as low (<600 MET·min·wk −1 ), medium (600–3000 or high (>3000 ; 600 equivalent 150 min...
Background Plasma concentrations of some lysophospholipids correlate with metabolic alterations in humans, but their potential as biomarkers insulin resistance (IR) is insufficiently known. We aimed to explore the association between plasma linoleoylglycerophosphocholine (LGPC) and objective measures IR adults different profiles. Methods studied 62 men women, ages 30 69 years, (29% normal weight, 59% overweight, 12% obese). Participants underwent a 5-point oral glucose tolerance test...
Abdominal obesity (AO) indirectly represents visceral adiposity and can be assessed by waist circumference (WC) measurement. In Latin America, cut-off points for the diagnosis of AO are based on Asian population data. We aim to establish WC predict major cardiovascular events (MACE) incident diabetes.We analyzed data from cohort PURE study in Colombia. were defined according maximum Youden index. Multivariate logistic regression was used obtain associations between MACE, diabetes, cumulative...
Abstract Disclosure: C.O. Mendivil: None. K. Puerto-Baracaldo: M. Amaya-Montoya: G. Parra-Serrano: D.C. Prada-Robles: S. Serrano-Gómez: L.M. Restrepo Giraldo: M.C. Fragozo-Ramos: V. Tangarife: Giraldo-González: C.A. Builes-Barrera: M.S. Naranjo-Vanegas: A. Gómez-Aldana: J.P. Llano: N. Gil-Ochoa: L.D. Nieves-Barreto: P.V. Gaete: Pérez-Mayorga: Background: Severe hypertriglyceridemia (sHTG) increases the risk of life-threatening acute pancreatitis and several other conditions. Primary sHTG is...
Background. Nonalcoholic fatty liver disease (NAFLD) is one of the leading causes chronic and closely associated with cardiometabolic disorders, being insulin resistance (IR) common pathogenic mechanism. The triglycerides/glucose (TyG) index triglycerides/HDL-c (TG/HDL) ratio are markers correlated IR. We compared capacity these two indexes, alongside IR, to detect NAFLD. Methods. In a cross-sectional cohort study, we examined 263 active military personnel from Colombian Air Force, aged...
The genetic substrate of severe hypertriglyceridemia (sHTG) in Latin America is insufficiently understood. To identify variants genes related to triglyceride (TG) metabolism among adults with sHTG from Colombia. In individuals plasma TG ≥ 880 mg/dL at least once their lifetime, we amplified and sequenced all exons intron/exon boundaries the LPL, APOC2, APOA5, GPIHBP1 LMF1. For each variant ascertained its location, zygosity, allelic frequency pathogenicity classification according American...
Introducción: La folistatina es una proteína capaz de neutralizar varias hormonas la familia del TGF-?, tales como activina, las proteínas morfogénicas hueso y miostatina. Al inactivar activina reduce secreción FSH. se produce además en el ovario muchos otros tejidos, por ello sospecha que tiene efectos. En ratones, deleción genética acompaña resistencia a insulina (RI). Sin embargo, asociación entre plasmática RI medida directamente no ha sido evaluada humanos.Métodos: 81 participantes 30...
Background Abnormal cellular lipid metabolism appears to underlie SARS-CoV-2 cytotoxicity and may involve inhibition of peroxisome proliferator activated receptor alpha (PPARα). Fenofibrate, a PPAR-α activator, modulates metabolism. Fenofibric acid has also been shown affect the dimerization angiotensin-converting enzyme 2, for SARS-CoV-2. Fenofibrate fenofibric have inhibit replication in cell culture systems