A5060642241- Regulation of Appetite and Obesity
- Pancreatic function and diabetes
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bariatric Surgery and Outcomes
- Drug Transport and Resistance Mechanisms
- Cancer Cells and Metastasis
- Nutritional Studies and Diet
- Treatment of Major Depression
- Adenosine and Purinergic Signaling
- Tryptophan and brain disorders
- Growth Hormone and Insulin-like Growth Factors
- Retinoids in leukemia and cellular processes
- Nutrition, Genetics, and Disease
- Diabetes Management and Research
- Single-cell and spatial transcriptomics
- Fibroblast Growth Factor Research
- Diabetes and associated disorders
- Pharmacology and Obesity Treatment
- RNA modifications and cancer
- Cholesterol and Lipid Metabolism
Mayo Clinic in Arizona
2021-2024
Mayo Clinic
2021-2022
WinnMed
2021
Universidad de Los Andes
2017-2019
Universidad de Los Andes
2017-2018
Background: Myokines are a group of protein mediators produced by skeletal muscle under stress or physical exertion. Even though their discovery and effects in cell culture animal models disease have elicited great enthusiasm, very little is known about role human metabolism. We assessed whether plasma concentrations three myokines (myonectin, myostatin fibroblast-derived growth factor 21 [FGF-21]) would be associated with direct indirect indicators insulin resistance (IR) individuals who...
Satiety, defined as the duration of sensation fullness, is usually measured by validated visual analog scales (VAS) for appetite. Gastric function plays a key role in food intake regulation. However, association between gastric emptying (GE) and VAS appetite unknown.In this cross-sectional study, 134 participants (mean [SEM] age = 39 [0.8] years, mean BMI 38 [0.5] kg/m2 , 67% females) completed simultaneous measurements GE After 320-kcal meal, was scintigraphy 100-mm 240 minutes. Satiation...
Abstract Background Prescription medications such as selective serotonin reuptake inhibitors (SSRIs), commonly used to treat depression, are associated with weight gain. The role of pharmacogenomics in predicting SSRI-induced gain is unclear. Methods In this retrospective cohort study from participants the Mayo Clinic RIGHT who were prescribed citalopram, paroxetine, sertraline, or fluoxetine, our aim was evaluate association metabolizer phenotype and total body after 6 months SSRIs...
Background Plasma concentrations of some lysophospholipids correlate with metabolic alterations in humans, but their potential as biomarkers insulin resistance (IR) is insufficiently known. We aimed to explore the association between plasma linoleoylglycerophosphocholine (LGPC) and objective measures IR adults different profiles. Methods studied 62 men women, ages 30 69 years, (29% normal weight, 59% overweight, 12% obese). Participants underwent a 5-point oral glucose tolerance test...
SummaryBackgroundGut L-type enteroendocrine cells (EECs) are intestinal chemosensory that secrete satiety hormones GLP-1 and PYY in response to activation of G-protein coupled receptors (GPCRs) by luminal components nutrient digestion microbial fermentation. Regulator Signaling (RGS) proteins negative regulators GPCR signaling. The expression profile RGS EECs, their potential role hormone secretion obesity is unknown.MethodsTranscriptomic profiling was completed native colonic EECs using...
The heterogeneity of the human intestinal epithelium has hindered understanding pathophysiology distinct specialized cell types on a single-cell basis in disease states. Described here is workflow for cryopreservation endoscopically obtained mucosal biopsies, subsequent preparation this tissue to yield highly viable fluorescence-activated sorting (FACS)isolated epithelial (IEC) suspensions compatible with successful library and deep RNA sequencing (scRNAseq). We validated protocol scRNAseq...
Autoimmunity against insulin-producing beta cells from pancreatic islets is a common phenomenon in type 1 diabetes and latent autoimmune adults. Some reports have also related beta-cell autoimmunity to insulin resistance (IR) 2 diabetes. However, the extent which components of present relates IR secretion nondiabetic adults uncertain.To explore association between antibodies glutamic acid decarboxylase (GADA), major antigen cells, indices whole-body capacity/insulin who do not diabetes.We...
Hereditary fructose intolerance, caused by mutations in the ALDOB gene, is an unusual cause of hypoglycemia. encodes enzyme aldolase B, responsible for hydrolysis 1-phosphate liver. Here, we report case a 33-year-old female patient who consulted due to repetitive episodes weakness, dizziness and headache after food ingestion. An ambulatory 72-h continuous glucose monitoring revealed multiple short hypoglycemic over day. After biochemical exclusion other endocrine causes hypoglycemia,...
Obesity is associated with alterations in cholesterol and bile acid (BA) metabolism. However, the interaction among dietary intake, absorption, BA metabolism patients obesity remains unclear. We conducted a 4-wk nutritional intervention nonrandomized clinical trial three different sequential diets for week following order: regular diet (RD); high calorie, high-fat (HCHF), washout period on RD; low-calorie, low-fat (LCLF). provided participants meal replacements during HCHF LCLF diets. A...
Introducción: La folistatina es una proteína capaz de neutralizar varias hormonas la familia del TGF-?, tales como activina, las proteínas morfogénicas hueso y miostatina. Al inactivar activina reduce secreción FSH. se produce además en el ovario muchos otros tejidos, por ello sospecha que tiene efectos. En ratones, deleción genética acompaña resistencia a insulina (RI). Sin embargo, asociación entre plasmática RI medida directamente no ha sido evaluada humanos.Métodos: 81 participantes 30...