A5000208722- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Chronic Disease Management Strategies
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and disorders
- Metabolism and Genetic Disorders
- Diabetes Management and Research
- Telomeres, Telomerase, and Senescence
- Genetics, Aging, and Longevity in Model Organisms
- Health Systems, Economic Evaluations, Quality of Life
- Obesity, Physical Activity, Diet
- Cancer, Hypoxia, and Metabolism
- Nutritional Studies and Diet
- Vitamin D Research Studies
- Blood Pressure and Hypertension Studies
- Cholesterol and Lipid Metabolism
Universidad de Los Andes
2020-2024
Universidad de Los Andes
2020-2024
Abstract Background The functionality of high-density lipoproteins (HDL) is a better cardiovascular risk predictor than HDL concentrations. One the key elements its apolipoprotein composition. Lecithin-cholesterol acyl transferase (LCAT) and cholesterol-ester transfer protein (CETP) are enzymes involved in HDL-mediated reverse cholesterol transport. This study assessed concentration activity LCAT CETP subspecies defined by their content apolipoproteins E (apoE) C-III (apoC-III) humans....
Abstract Disclosure: C.O. Mendivil: None. K. Puerto-Baracaldo: M. Amaya-Montoya: G. Parra-Serrano: D.C. Prada-Robles: S. Serrano-Gómez: L.M. Restrepo Giraldo: M.C. Fragozo-Ramos: V. Tangarife: Giraldo-González: C.A. Builes-Barrera: M.S. Naranjo-Vanegas: A. Gómez-Aldana: J.P. Llano: N. Gil-Ochoa: L.D. Nieves-Barreto: P.V. Gaete: Pérez-Mayorga: Background: Severe hypertriglyceridemia (sHTG) increases the risk of life-threatening acute pancreatitis and several other conditions. Primary sHTG is...
The genetic substrate of severe hypertriglyceridemia (sHTG) in Latin America is insufficiently understood. To identify variants genes related to triglyceride (TG) metabolism among adults with sHTG from Colombia. In individuals plasma TG ≥ 880 mg/dL at least once their lifetime, we amplified and sequenced all exons intron/exon boundaries the LPL, APOC2, APOA5, GPIHBP1 LMF1. For each variant ascertained its location, zygosity, allelic frequency pathogenicity classification according American...
The magnitude of the mortality benefit conferred by good integral metabolic control in diabetes not sufficiently known, especially among Latin American patients. We prospectively studied association between sustained blood glucose (HbA1c<7%), systolic pressure (SBP) (<130 mmHg) and LDL (LDLc, <100mg/dL) non-HDL (non-HDLc, <130 mg/dL) cholesterol, death from any cause all adult patients with diagnosed Colombia.
Data on dietary calcium and vitamin D intake from Latin America are scarce. We explored the main correlates sources of in a probabilistic, population-based sample Colombia. studied 1554 participants aged 18-75 five different geographical regions. Dietary was assessed by employing 157-item semi-quantitative food frequency questionnaire national international composition tables. Daily decreased with increasing age, 230 IU/day 18-39 age group to 184 60-75 (P -trend < 0.001). Vitamin positively...
Abstract Background The functionality of high-density lipoproteins (HDL) is a better cardiovascular risk predictor than HDL concentrations. One the key elements its apolipoprotein composition. Lecithin-cholesterol acyl transferase (LCAT) and cholesterol-ester transfer protein (CETP) are enzymes involved in HDL-mediated reverse cholesterol transport. This study assessed concentration activity LCAT CETP subspecies defined by their content apolipoproteins E (apoE) C-III (apoC-III) humans....
Abstract Background High-density lipoproteins (HDL) in plasma are strongly and negatively associated with cardiovascular risk, yet interventions to raise HDL have not improved outcomes. functionality heterogeneity may hold the clue this paradox. The apolipoprotein composition of be an important determinant their functionality. Lecithin-cholesterol acyl transferase (LCAT) cholesterol-ester transfer protein (CETP) key enzymes for HDL-mediated reverse cholesterol transport. We assessed...
Abstract Background High-density lipoproteins (HDL) functionality predicts cardiovascular risk better than HDL concentrations. The apolipoprotein composition of may be a determinant their function. Lecithin-cholesterol acyl transferase (LCAT) and cholesterol-ester transfer protein (CETP) are key enzymes for HDL-mediated reverse cholesterol transport. We assessed the distribution activity LCAT CETP in subspecies defined by content apolipoproteins E (apoE) C-III (apoC-III) humans. Methods...
The relative importance of the control different metabolic risk factors for prevention chronic kidney disease among patients with diabetes in real life conditions is insufficiently understood.We evaluated effect achievement glycated hemoglobin A1c (HbA1c), systolic blood pressure (SBP), and low-density lipoprotein cholesterol (LDLc) or non-high-density (non-HDLc) goals (ABC goals) on development incident (iCKD) diabetes.In a nationwide registry all individuals diagnosed assisted by health...