A5045212300- HIV Research and Treatment
- Immune Cell Function and Interaction
- Biological Research and Disease Studies
- Oral microbiology and periodontitis research
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- Cytomegalovirus and herpesvirus research
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Antifungal resistance and susceptibility
- HIV/AIDS oral health manifestations
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- Kruppel-like factors research
- Immunotherapy and Immune Responses
- Wnt/β-catenin signaling in development and cancer
- Extracellular vesicles in disease
- Clostridium difficile and Clostridium perfringens research
- Hepatitis C virus research
- Microscopic Colitis
- Gut microbiota and health
Tecnológico de Monterrey
2024
Universidad de Guadalajara
2019-2022
Mexican Social Security Institute
2013-2015
HIV infection is characterized by CD4+ T-cells depletion related to gut damage, microbial translocation, immune activation and intestinal systemic low-grade inflammation. With the use of antiretroviral treatment, these alterations in HIV+ patients reach similar levels HIV- controls. However, almost 20% have deficient reconstitution T-cells, which make them more susceptible develop non-AIDS AIDS comorbidities.HIV+ on ART, with sustained virologic control were grouped according their as:...
Abstract Background WNT signaling pathways are significantly altered during cancer development. Vertebrates possess two classes of pathways: the “canonical” WNT/β-catenin pathway, and “non-canonical” including WNT/Ca2 + WNT/Planar cell polarity [PCP] signaling. WNT4 influences hematopoietic progenitor expansion survival; however, function in development resulting implications for oncogenesis poorly understood. The aim this study was twofold: first, to determine expression mature peripheral...
The CD95 pathway is a critical apoptotic used by immune cells to avoid cancer development. ligand (CD95L) found in several forms, as cell membrane-associated form, soluble metalloprotease-cleaved and but membrane-bound CD95L released on cell-derived exosomes. In this study, we cell-based assay evaluate the activity of proapoptotic sera from healthy individuals breast patients. We confirmed that our using Jurkat was sensitive presence serum, apoptosis induction mechanisms other than...
Abstract Background: HIV infection is mainly described by depletion of CD4 + T-cells, however this not only occurs in infected cells, also arise uninfected immunological cells through the bystander effect. Extrinsic cell death, particular Fas pathway has been studied extensively, and an expression increase both its ligand receptor reported, TRAIL less explored context, little relating to immune activation characteristic disease. This study aims examine effect death pathways CD3 T-cells CD14...
<h3>Background</h3> HIV infection is characterized by immune cells depletion, apoptosis one of the main mechanisms described. It has been reported that, union to coreceptor CXCR4 can induce Fas independent on T cells. In a few <i>in vitro</i> studies it proved that stimulation with gp120, cause upregulation TRAIL receptors and consequent sensitivity this pathway. work, our aim was measure if CD4+T lymphocytes from HIV+ patients, had increased expression ligand death (DR) 5/4 and, evaluate...
<h3>Background</h3> Antiretroviral Therapy (ART) inhibits HIV replication, allowing immune reconstitution; however, some patients have an insufficient reconstitution, resulting in high levels of activation, microbial translocation, inflammation and intestinal dysbiosis. Since microbiota its metabolites, such as Short-Chain Fatty Acids (SCFA) are linked to status, alteration one or both could be related poor T cells reconstitution. <h3>Methods</h3> HIV+ with ART, grouped immunologic...