A5103010463- Respiratory viral infections research
- Influenza Virus Research Studies
- Antibiotic Resistance in Bacteria
- Enterobacteriaceae and Cronobacter Research
- Antibiotic Use and Resistance
- Antimicrobial Resistance in Staphylococcus
- COVID-19 epidemiological studies
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Infection Control and Ventilation
- Vibrio bacteria research studies
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Urinary Tract Infections Management
- Emergency and Acute Care Studies
- Sepsis Diagnosis and Treatment
- Frailty in Older Adults
- Nosocomial Infections in ICU
- Clostridium difficile and Clostridium perfringens research
- Streptococcal Infections and Treatments
- Viral Infections and Immunology Research
- SARS-CoV-2 detection and testing
- Infections and bacterial resistance
- Respiratory Support and Mechanisms
- Viral Infections and Outbreaks Research
North York General Hospital
2016-2025
Health Sciences Centre
2020-2025
University of Toronto
2011-2025
Sunnybrook Health Science Centre
2019-2025
York General Hospital
2006-2022
New York Proton Center
2016-2022
Communities In Schools of Orange County
2022
Manhattan Institute for Policy Research
2022
Oregon Medical Research Center
2022
Lindsay Unified School District
2022
Influenza is an important cause of morbidity and mortality among older adults. Even so, effectiveness influenza vaccine for adults has been reported to be lower than younger adults, the impact frailty on (VE) outcomes uncertain. We aimed study VE against hospitalization in focusing frailty.We report trivalent (TIV) people ≥65 years age hospitalized during 2011-2012 season using a multicenter, prospective, test-negative case-control design. A validated index (FI) was used measure...
To investigate the occurrence and molecular mechanisms associated with carbapenemases in carbapenem-resistant Gram-negative isolates from Canadian cases. Twenty hospital sites across Canada submitted for a 1 year period starting September 2009. All Enterobacteriaceae MICs ≥2 mg/L Acinetobacter baumannii Pseudomonas aeruginosa ≥16 of carbapenems were to National Microbiology Laboratory (NML) where carbapenem confirmed by Etest characterized PCR carbapenemase genes, antimicrobial...
Penicillin nonsusceptibility has been demonstrated in group B streptococci (GBS), but there is limited information regarding mechanisms of resistance. We report a case GBS with reduced susceptibility to penicillin emerging after long-term suppressive oral therapy for prosthetic joint infection. Molecular characterization the isolate before and revealed 5 mutations ligand-binding regions PBP1a, -2a, -2x not previously reported GBS.
To determine trends, patient characteristics, and outcome of patients with healthcare-associated influenza in Canadian hospitals.Prospective surveillance laboratory-confirmed among hospitalized adults was conducted from 2006 to 2012. Adults positive test results at or after admission the hospital were assessed. Influenza considered be healthcare associated if symptom onset equal more than 96 hours a facility readmitted less discharge admitted transfer another facility. Baseline...
ABSTRACT Carbapenemase-producing Enterobacteriaceae (CPE) are increasing globally; here we report on the investigation of CPE in Canada over a 5-year period. Participating acute care facilities across submitted carbapenem-nonsusceptible from 1 January 2010 to 31 December 2014 National Microbiology Laboratory. All were characterized by antimicrobial susceptibilities, pulsed-field gel electrophoresis, multilocus sequence typing, and plasmid restriction fragment length polymorphism analysis had...
Background Waning immunity from seasonal influenza vaccination can cause suboptimal protection during peak activity. However, vaccine effectiveness studies assessing waning using vaccinated and unvaccinated individuals are subject to biases. Aim We examined the association between time since laboratory-confirmed assess change in over time. Methods Using linked laboratory health administrative databases Ontario, Canada, we identified community-dwelling aged ≥ 6 months who received an before...
In patients with invasive pneumococcal disease who have been previously exposed to antibiotics, the time elapsed from end of most recent treatment course appears be important factor predicting antimicrobial resistance.
Diagnosis of influenza in older adults may be complicated by atypical presentations or when patients present with complications an underlying illness. We aimed to identify clinical characteristics and epidemiological factors associated among community-dwelling aged ≥60 years presenting emergency departments.We identified influenza-compatible chief complaints departments six acute care hospitals Ontario, Canada during the 2011/12 2012/13 seasons. Clinical characteristics, medical history...
Background. Clostridium difficile infection (CDI) is the most common cause of nosocomial infectious diarrhea and may result in severe complications including death. We conducted a prospective study to identify risk factors for CDI (cCDI).
Background/objectives Influenza is associated with significant morbidity and mortality, particularly for older adults. Persistent functional decline following hospitalization has important impacts on adults' wellbeing independence, but been under‐studied in relation to influenza. We aimed investigate persistent change adults admitted hospital influenza other acute respiratory illness (ARI). Design Protective observational cohort study. Setting Canadian Immunization Research Network Serious...
Respiratory syncytial virus (RSV) disease in older adults is undercharacterized. To help inform future immunization policies, this study aimed to describe the burden Canadian aged ≥50 years hospitalized with RSV.Using administrative data and nasopharyngeal swabs collected from active surveillance among an acute respiratory illness (ARI) during 2012-2013, 2013-2014, 2014-2015 influenza seasons, RSV was identified using a multiplex polymerase chain reaction test associated burden, incidence,...
Respiratory syncytial virus (RSV) contributes significantly to morbidity in children, placing substantial burdens on health systems, thus RSV vaccine development and program implementation are a public priority. More data burden needed by policymakers identify priority populations formulate prevention strategies as vaccines developed licensed.Using administrative data, we calculated incidence rates of hospitalization population-based birth cohort all children born over six-year period (May...
Abstract Background Drivers of COVID-19 severity are multifactorial and include multidimensional potentially interacting factors encompassing viral determinants host-related (i.e., demographics, pre-existing conditions and/or genetics), thus complicating the prediction clinical outcomes for different severe acute respiratory syndrome coronavirus (SARS-CoV-2) variants. Although millions SARS-CoV-2 genomes have been publicly shared in global databases, linkages with detailed data scarce....
Abstract Background Identification of transmission networks carbapenemase-producing organisms (CPO) is critical to identifying their reservoirs and limiting spread. This study aimed use whole-genome sequencing identify genomic relationships between CP Enterobacter (CP-Ent) in Ontario, Canada over a 15-year period. Methods All CP-Ent cases identified by prospective population-based surveillance the Toronto/Peel Region from first isolate 2007 2021, hospital sinks (2016-2019), wastewater...
Abstract Background Case and control definitions may impact VE estimates in observational studies. Using a TND design, we evaluated how influenza vaccine effectiveness against ARI hospitalizations changed when 1) cases were detected through nasopharyngeal swabs (NPS) only versus multiple specimens 2) controls included or excluded other preventable diseases (VPD). Methods Adults aged ≥40 years hospitalized for had NPS saliva sputum tested using Luminex RSV/influenza multiplex PCR assay....
Abstract Background Oseltamivir is recommended for the treatment of adults hospitalized with influenza, but adherence often suboptimal. This may be due to doubts about reliability evidence supporting its benefits, particularly when initiation delayed. We aimed assess effectiveness oseltamivir in reducing mortality older a focus on timing initiation. Methods The CIRN-SOS Network gathered data severe respiratory illnesses across 5 Canadian provinces during influenza seasons 2012–2019....
ABSTRACT Invasive Group A streptococcal (iGAS) infections are rising in Canada and wordwide. The 2022–2023 Ontario iGAS season was among the highest recorded, a trend continuing 2023–2024. We sequenced 38 invasive (blood) 117 non-invasive (pharyngeal) Streptococcus pyogenes clinical isolates from Toronto (January–May 2023) to compare between two cohorts against published sequences determine if any genomic changes accounted for trend. Results demonstrated limited clustering with one small...
Objectives: This study examined Klebsiella pneumoniae clinical isolates and their bla KPC plasmids to determine potential relatedness of the harbouring carbapenem resistance mechanisms.Methods: K. carbapenemase (KPC)-producing from New York City (NYC) (n¼19) Toronto (n ¼2) were typed by PFGE multilocus sequence typing (MLST).bla -harbouring transformed into Escherichia coli DH10B TM , restricted using EcoRI analysed for content replicon (rep) type.Susceptibility profiles strains determined...
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