Thomas Chandler

ORCID: 0000-0002-2284-6213
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About
Contact & Profiles
Research Areas
  • Pneumonia and Respiratory Infections
  • Respiratory viral infections research
  • Disaster Management and Resilience
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Climate Change and Health Impacts
  • Disaster Response and Management
  • Service-Learning and Community Engagement
  • COVID-19 diagnosis using AI
  • COVID-19 Clinical Research Studies
  • SARS-CoV-2 and COVID-19 Research
  • Health disparities and outcomes
  • Tuberculosis Research and Epidemiology
  • Tracheal and airway disorders
  • Artificial Intelligence in Healthcare and Education
  • Long-Term Effects of COVID-19
  • Educator Training and Historical Pedagogy
  • Influenza Virus Research Studies
  • Climate Change, Adaptation, Migration
  • Clinical Reasoning and Diagnostic Skills
  • Chronic Disease Management Strategies
  • Emergency and Acute Care Studies
  • Cerebrovascular and Carotid Artery Diseases
  • Community and Sustainable Development
  • Education and Critical Thinking Development
  • Machine Learning in Healthcare

Norton Healthcare
2022-2025

Columbia University
2012-2023

Earth Island Institute
2016-2022

University of Louisville
2017-2022

Neurological Surgery
2020

Nearly all existing respiratory syncytial virus (RSV) incidence estimates are based on real-time polymerase chain reaction (RT-PCR) testing of nasal or nasopharyngeal (NP) swabs. Adding additional specimen types to NP swab RT-PCR increases RSV detection. However, prior studies only made pairwise comparisons and the synergistic effect adding multiple has not been quantified. We compared diagnosis by alone versus plus saliva, sputum, serology.This was a prospective cohort study over two...

10.1007/s40121-023-00805-1 article EN cc-by-nc Infectious Diseases and Therapy 2023-05-06

ABSTRACT Background RSV detection improves if an additional specimen is collected, but the impact of testing saliva and multiple types has not been assessed. We quantified increase with collection over nasopharyngeal swab (NPS) alone. Methods Prospectively enrolled hospitalized adults aged ≥40 years acute respiratory illness in seven hospitals US Canada had NPS, saliva, sputa, acute/convalescent sera collected tested. Results Among 3,669 participants, 100% 97.7% 33.0% sputum, 33.4% paired...

10.1101/2025.01.14.25320406 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2025-01-15

During the COVID-19 pandemic, a significant decline in Mycoplasma pneumoniae was observed; however, M. re-emerged globally 2023. Here, we describe current outbreak of infections United States (US). More than 287 million patient records from all 50 states US were reviewed to identify patients with diagnosis between 1 January 2017 and 30 September 2024. A c-chart created by calculating mean standard error (SE) cases during pre-COVID-19 pandemic period, upper control limit (UCL) set at 3 SE...

10.3390/pathogens14010060 article EN cc-by Pathogens 2025-01-11

Controversy exists regarding the clinical effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPSV23) for prevention serotype-specific community-acquired pneumonia (CAP). The objective this study was to define PPSV23 CAP hospitalizations due vaccine-contained serotypes. This secondary analysis a nested case-control, test-negative design adult patients hospitalized between 1 June 2014 and 31 March 2017. Cases included with S. pneumoniae serotype contained in PPSV23. Urinary...

10.3390/microorganisms10030560 article EN cc-by Microorganisms 2022-03-04

During the COVID-19 pandemic, a significant decline in Mycoplasma pneumoniae was observed. However, M. reemerged globally 2023. Here we describe current outbreak of infections United States (US). More than 287 million patient records from all 50 states US were reviewed to identify patients with diagnosis between January 1, 2017, and September 30, 2024. A C-chart created by calculating mean standard error (SE) cases during pre-COVID-19 pandemic period, upper control limit (UCL) set at 3 SE...

10.20944/preprints202412.2381.v2 preprint EN 2025-01-06

Abstract Background Case and control definitions may impact VE estimates in observational studies. Using a TND design, we evaluated how influenza vaccine effectiveness against ARI hospitalizations changed when 1) cases were detected through nasopharyngeal swabs (NPS) only versus multiple specimens 2) controls included or excluded other preventable diseases (VPD). Methods Adults aged ≥40 years hospitalized for had NPS saliva sputum tested using Luminex RSV/influenza multiplex PCR assay....

10.1093/ofid/ofae631.247 article EN cc-by Open Forum Infectious Diseases 2025-01-29

Background After the COVID-19 pandemic, a re-emerging of Mycoplasma pneumoniae infections has been reported globally. The objective this study is to define epidemiology M. in city Louisville. Methods All cases infection since January 1, 2017 until December 31, 2024 were evaluated. A baseline cohort from March 2020 was used develop expected upper control limits for detecting infection. Infections aggregated by annual quarter and depicted c-charts. Results An outbreak identified starting...

10.59541/001c.129836 article EN cc-by-nd Norton Healthcare Medical Journal 2025-02-17

The epidemiology and outcomes of community-acquired pneumonia (CAP) in immunocompromised hosts (ICHs) are not well defined. objective this study was to define the CAP ICHs as compared with non-ICHs.This ancillary included a prospective cohort hospitalized adult Louisville residents from 1 June 2014 31 May 2016. An ICH defined per criteria Centers for Disease Control Prevention. Geospatial explored associations between income level, race, age. Mortality non-ICHs evaluated during...

10.1093/ofid/ofad565 article EN cc-by Open Forum Infectious Diseases 2023-11-01

The use of artificial intelligence in healthcare is rapidly growing, with great potential to assist medical professionals diagnosis and treatment complex conditions. In this case report, the recommendations a pulmonary consultation are compared from large language model (LLM), ChatGPT, regards non-resolving pneumonia. by ChatGPT were found be consistent consultation, no given inappropriate. As shown early generations LLM such as able provide appropriate for management patient condition.

10.59541/001c.75456 article EN cc-by-nd Norton Healthcare Medical Journal 2023-05-17

This article describes the design and evaluation of a blended online/face-to-face course completed by more than 6000 learners throughout United States America internationally. The educational impact was monitored using variety strategies. results, in terms achieved knowledge overall satisfaction, indicate that focus on online instruction combined with face-to-face, hands-on activities showed statistically significant improvement learners' understanding material, while also validating...

10.1080/10494820.2011.593524 article EN Interactive Learning Environments 2011-08-30

This article presents the development of a program and results study to evaluate an online distancebased learning (DBL) for competency-based, basic emergency preparedness training employees local health departments nationwide. The was developed implemented beginning in May 2003 by Columbia University’s Center Public Health Preparedness (CU-CPHP), designed be delivered two parts. first part program, providing knowledge required public preparedness. second downloadable template, which student...

10.1177/003335490812300521 article EN Public Health Reports 2008-09-01

Streptococcus pneumoniae remains a primary pathogen in hospitalized patients with community-acquired pneumonia (CAP). The objective of this study was to define the epidemiology pneumococcal Louisville, Kentucky, and estimate burden United States (US). This nested prospective population-based cohort all adult residents who were CAP from 1 June 2014 31 May 2016. In CAP, urinary antigen detection 24 S. serotypes (UAD-24) performed. annual incidence calculated. distribution characterized....

10.3390/microorganisms11112813 article EN cc-by Microorganisms 2023-11-20

Abstract BACKGROUND Preoperative depression is a risk factor for poor outcomes after spine surgery. OBJECTIVE To understand effects of on surgery and healthcare resource utilization. METHODS Using IBM’s MarketScan Database, we identified 52 480 patients who underwent spinal fusion. Retained were classified into 6 phenotype groups based International Classification Disease, 9th/10th Revision (ICD-9/10) codes use/nonuse antidepressant medications: major depressive disorder (MDD), other...

10.1093/neuros/nyab096 article EN Neurosurgery 2021-02-25

Abstract Objective This collective case study examined how and why specific organizational decision-making processes transpired at 2 large suburban county health departments in lower New York State during their response to Hurricane Sandy 2012. The also the relationships that agencies developed with other emerging established organizations within respective systems. Methods In investigating these themes, authors conducted in-depth, one-on-one interviews 30 senior-level public staff first...

10.1017/dmp.2016.68 article EN Disaster Medicine and Public Health Preparedness 2016-05-11

Objective This study examines family strategies for coping and adaptation to social disruption from the 2010 Deepwater Horizon oil spill (DHOS) in south Louisiana. Background The DHOS is a technological disaster of unprecedented scale ongoing impact, including socioeconomic families. Method Using data focus groups, grounded‐theory methods informed thematic analysis spill‐related economic loss mechanisms among families spill‐affected region. Results Key findings were as follows: (a) long‐term...

10.1111/fare.12510 article EN Family Relations 2020-10-20

Abstract Background In hospitalized patients, nasopharyngeal (NP) swabs are the most common samples obtained for Respiratory Syncytial Virus (RSV) PCR testing. However, adding sputum is known to increase diagnostic yield, and saliva has been successfully used viral respiratory infection diagnosis. We sought compare RSV prevalence detected by testing of NP swab alone versus plus in adult patients with acute illness (ARI). Methods This ongoing, prospective cohort study enrolled aged ≥40 years...

10.1093/ofid/ofac492.449 article EN Open Forum Infectious Diseases 2022-12-01
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