A5020992477- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- HIV/AIDS Research and Interventions
- Emergency and Acute Care Studies
- Tuberculosis Research and Epidemiology
- HIV Research and Treatment
- Nosocomial Infections in ICU
- HIV/AIDS drug development and treatment
- Urinary Tract Infections Management
- COVID-19 Clinical Research Studies
- Antibiotic Resistance in Bacteria
- HIV, Drug Use, Sexual Risk
- HIV-related health complications and treatments
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Infectious Diseases and Tuberculosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Antimicrobial Resistance in Staphylococcus
- SARS-CoV-2 and COVID-19 Research
- Cervical Cancer and HPV Research
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Immune Cell Function and Interaction
- Mycobacterium research and diagnosis
SUNY Upstate Medical University
2024
George Washington University
2018-2022
University of Louisville
2001-2022
Washington University Medical Center
2021
Health and Environmental Sciences Institute
2020-2021
Providence Health & Services
2019-2020
Health Center
2019-2020
Providence College
2020
Hospital Universitario de Gran Canaria Doctor Negrín
2020
University of Louisville Hospital
2017-2020
Understanding the burden of community-acquired pneumonia (CAP) is critical to allocate resources for prevention, management, and research. The objectives this study were define incidence, epidemiology, mortality adult patients hospitalized with CAP in city Louisville, estimate US population.This was a prospective population-based cohort residents Kentucky, from 1 June 2014 31 May 2016. Consecutive enrolled at all hospitals Louisville. annual incidence calculated. Geospatial epidemiology used...
This study examines in vitro antimicrobial resistance data from Escherichia coli isolates obtained urine samples of U.S. outpatients between 2000 and 2010 using The Surveillance Network (TSN). Antimicrobial susceptibility results (n = 12,253,679) showed the greatest increases E. to for ciprofloxacin (3% 17.1%) trimethoprim-sulfamethoxazole (TMP-SMX) (17.9% 24.2%), whereas nitrofurantoin (0.8% 1.6%) ceftriaxone (0.2% 2.3%) minimal change. From 2010, urinary TMP-SMX among increased substantially.
An epidemiological link between respiratory infection and acute myocardial infarction (AMI) has been suggested, recent data indicate that there is an association AMI pneumococcal community-acquired pneumonia (CAP) in hospitalized patients. The objective of this study was to investigate the with severity at hospitalization clinical failure during among patients CAP.An observational, retrospective involving consecutive CAP performed Veterans Hospital Louisville, Kentucky. Patients admitted...
A retrospective analysis was performed using The Surveillance Network, USA, to examine the prevalence of antibiotic resistance among urine isolates from U.S. female outpatients in 2012 and assessed trends comparing data 2003 2012. most common pathogen identified (n = 285,325) Escherichia coli (64.9% isolates). In 2012, E. nitrofurantoin low (<3%) across all age groups. ciprofloxacin high adults (11.8%) elderly (29.1%). When adults, changed only slightly (from 0.7% 0.9%), whereas increases...
We studied antimicrobial-resistant Klebsiella pneumoniae for 1998-2010 by using data from The Surveillance Network. Susceptibility results (n = 3,132,354) demonstrated significant increases in resistance to all antimicrobial drugs studied, except tetracycline. Cross-resistance among carbapenem-resistant K. was lower tetracycline and amikacin.
Approximately 20% of patients infected with SARS-CoV-2 (COVID-19) develop potentially life-threatening pathologies involving hyperinflammation, cytokine storm, septic shock complications, coagulation dysfunction, and multiple organ failure. Blood levels the prototypic acute phase reactant, C-reactive protein (CRP), which is hepatically synthesized released in response to interleukin-6 stimulation, markedly elevated COVID-19. Markedly high CRP correlate poor prognosis for survival. Insights...
To examine the prevalence of multidrug-resistant (MDR) urinary Escherichia coli among US outpatients and to assess antimicrobial activity oral antibiotics commonly used treat tract infections (UTIs) against MDR isolates.Antimicrobial susceptibility testing data from outpatient urine cultures in The Surveillance Network (TSN) Database USA were analysed. Six agents six separate drug classes included: ampicillin, cefalotin, ciprofloxacin, nitrofurantoin, trimethoprim/sulfamethoxazole...
The identification of Streptococcus pneumoniae bacteremia in hospitalized patients with community-acquired pneumonia is considered by some investigators to be an exclusion criterion for early switch from intravenous oral therapy.To determine whether the therapy such patients, once bx;1patient reaches clinical stability, associated poor outcome.The medical records 400 at Veterans Affairs Medical Center Louisville (Louisville, Ky) were reviewed identify bacteremic S pneumoniae. Four criteria...
Community-acquired pneumonia (CAP) severity scores can identify patients at low risk for mortality who may be suitable ambulatory care. Here, we follow the clinical course of hospitalized with CAP due to 2009 H1N1 influenza.To evaluate role as predictors mortality.This was a secondary data analysis influenza confirmed by reverse transcriptase polymerase chain reaction enrolled in CAPO (Community-Acquired Pneumonia Organization) international cohort study. PSI (Pneumonia Severity Index),...
The management of Candida albicans endophthalmitis in intravenous drug abusers (IVDAs) has yet to be established. Early vitrectomy was previously reported as a promising treatment for C. endophthalmitis. In our series, diagnosed 15 IVDAs. Funduscopic examinations confirmed severe vitritis 12 patients and chorioretinitis three. Blood vitreal cultures were positive seven eight patients, respectively. Patients with received antifungal therapy before after vitrectomy. Amphotericin B or...
We examined associations between stimulant use (methamphetamine and cocaine) other substances (nicotine, marijuana, alcohol inhaled nitrites) with immune function biomarkers among HIV-seropositive (HIV +) men taking highly active antiretroviral therapy (ART) HIV-seronegative (HIV-) in the Multicenter AIDS Cohort Study. Among HIV + men, cumulative adherence to ART (4.07, 95% confidence interval [CI]: 3.52, 4.71, per 10 years of adherent use), recent cohort enrolment (1.38; CI: 1.24, 1.55)...
Severe community-acquired pneumonia (CAP) portends a serious prognosis. The temporal trend in outcome of severe CAP is not well established. We evaluated the trends outcomes CAP.This secondary analysis 800 patients with enrolled Community-Acquired Pneumonia Organization International Cohort. was defined as requiring admission to intensive care unit. Only admitted ICU upon hospital were included this study. assessed these during three time periods: Period I (June 2001 April 2004), II (May...
Routine cervical cancer screening is important for women living with HIV (WLH) due to the greater incidence and persistence of high-risk HPV (HR-HPV) infection. HR-HPV self-sampling has been proposed overcome barriers in-office in underserved populations. However, little known about baseline knowledge acceptability among WLH. This paper describes WLH’s experiences needs regarding screening, specifically self-sampling, seeks reconcile their views providers. In total, 10 providers 39 WLH...