A5100345256- Spine and Intervertebral Disc Pathology
- Pain Mechanisms and Treatments
- Asthma and respiratory diseases
- Medical Imaging and Analysis
- Tea Polyphenols and Effects
- Musculoskeletal pain and rehabilitation
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Machine Learning in Bioinformatics
- Spinal Fractures and Fixation Techniques
- Migraine and Headache Studies
- Liver Disease Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Genetic factors in colorectal cancer
- Respiratory viral infections research
- Cancer Mechanisms and Therapy
- Mitochondrial Function and Pathology
- Anesthesia and Pain Management
- Genomics and Phylogenetic Studies
- Allergic Rhinitis and Sensitization
- Neonatal and fetal brain pathology
- RNA and protein synthesis mechanisms
- IL-33, ST2, and ILC Pathways
- Cancer Genomics and Diagnostics
- Nitric Oxide and Endothelin Effects
Southwest Medical University
2013-2025
Pfizer (United States)
2019-2025
Nanjing University of Chinese Medicine
2021-2025
Jiangsu Province Hospital
2021-2025
Chinese University of Hong Kong
2022-2024
Tianjin University of Technology
2014-2024
Tianjin University
2024
Shanxi Medical University
2024
Affiliated Hospital of Southwest Medical University
2018-2024
Yale University
2017-2024
Tea is among the most consumed drink worldwide, and its strong antioxidant activity considered as main contributor to several health benefits, such cardiovascular protection anticancer effect. In this study, activities of 30 tea infusions, which were obtained by mimic drinking public, from green, black, oolong, white, yellow dark teas, evaluated using ferric-reducing power (FRAP) Trolox equivalent capacity (TEAC) assays, ranging 504.80 ± 17.44 4647.47 57.87 µmol Fe2+/g dry weight (DW) 166.29...
ABSTRACT Background RSV detection improves if an additional specimen is collected, but the impact of testing saliva and multiple types has not been assessed. We quantified increase with collection over nasopharyngeal swab (NPS) alone. Methods Prospectively enrolled hospitalized adults aged ≥40 years acute respiratory illness in seven hospitals US Canada had NPS, saliva, sputa, acute/convalescent sera collected tested. Results Among 3,669 participants, 100% 97.7% 33.0% sputum, 33.4% paired...
Tea has been reported to prevent and manage many chronic diseases, such as cancer, diabetes, obesity, cardiovascular the antioxidant capacity of tea may be responsible for these health benefits. In this study, capacities fat-soluble, water-soluble, bound-insoluble fractions 30 Chinese teas belonging six categories, namely green, black, oolong, dark, white, yellow teas, were systematically evaluated, applying ferric-reducing power Trolox equivalent assays. addition, total phenolic contents...
Graphical abstractAbstractBackgroundMUPPITS-2 was a randomized, placebo-controlled clinical trial that demonstrated mepolizumab (anti-IL-5) reduced exacerbations and blood airway eosinophils in urban children with severe eosinophilic asthma. Despite this reduction eosinophilia, exacerbation risk persisted certain patients treated mepolizumab. This raises the possibility subpopulations of exist contribute to breakthrough exacerbations.ObjectiveWe aimed determine effect on childhood...
Bovine endothelial constitutive nitric oxide synthase (eNOS) was expressed inE. colias a soluble, catalytically active enzyme using the pCW expression vector coexpressed with plasmid, pGroELS, encoding chaperonins groEL and groES. TheE. coliBL21 cultures reproducibly synthesized 6-10 mg of recombinant per liter culture. The eNOS protein purified 2′5′-ADP Sepharose 4B appeared as single band apparent molecular mass 135 kDa on SDS/PAGE. resting is predominantly high spin an absorbance maximum...
Although considerable effort has been expended developing drug candidates for Alzheimer disease, none have yet succeeded owing to the lack of efficacy or safety concerns. One potential shortcoming current approaches disease discovery and development is that they rely primarily on transformed cell lines animal models substantially overexpress wild-type mutant proteins. It possible failures thus far are caused in part by limits these approaches, which do not accurately reveal how will behave...
Objective Previous studies of neuropathic pain have suggested that the P2X4 purinoceptor (P2X4R) in spinal microglia is essential for maintaining allodynia following nerve injury. However, little known about its role inflammatory soup-induced trigeminal allodynia, which closely mimics chronic migraine status. Here, we determined contributions P2X4R and related signaling pathways an model. Methods gene protein levels nucleus caudalis were analyzed repeated dural soup infusions. p38,...
Prolonged bed rest may cause changes in the autonomic nervous system that are related to cognition and emotion. This study adopted an emotional flanker task evaluate effect of 45 days -6° head-down (HDBR) on executive functioning 16 healthy young men at each six time points: second-to-last day before period, eleventh, twentieth, thirty-second fortieth during eighth after period. In addition, self-report inventories (Beck Anxiety Inventory, BAI; Beck Depression BDI; Positive Affect Negative...
Abstract Background Case and control definitions may impact VE estimates in observational studies. Using a TND design, we evaluated how influenza vaccine effectiveness against ARI hospitalizations changed when 1) cases were detected through nasopharyngeal swabs (NPS) only versus multiple specimens 2) controls included or excluded other preventable diseases (VPD). Methods Adults aged ≥40 years hospitalized for had NPS saliva sputum tested using Luminex RSV/influenza multiplex PCR assay....
Abstract Background Most epidemiologic studies and clinical testing use a single nasal/nasopharyngeal swab for RSV detection. Previous have documented that detection improves if additional specimen is added to swab, but the impact of using multiple types has not been assessed. We quantified increase in compared nasopharyngeal (NPS) alone. Methods Prospectively enrolled hospitalized adults aged ≥40 years with acute respiratory illness seven hospitals US Canada had NPS, saliva, sputa,...
Abstract Background and Aim Considering the large size of potential population limitations common detection methods, covert hepatic encephalopathy (CHE) is difficult to screen for routinely. The present study aims explore EncephalApp Stroop Test as a smartphone‐based CHE screening tool in China. Methods A multicenter, single‐visit was carried out. cutoff Chinese translation determined by using standardized psychometric score (PHES) cirrhotic patients gold standard. Indicators reflecting time...
Abstract Background While the pivotal randomized clinical trial documented efficacy of RSVpreF vaccine (Abrysvo) against RSV-related LRTD, limited number hospitalizations and ED visits hampered VE assessment for these outcomes. We evaluated Abrysvo’s effectiveness 1st occurrence inpatient or LRTD in KPSC, a large US healthcare system.Table 1.Characteristics study population, KPSC Methods In this test-negative case control study, we assessed among adults ≥60 years age by analyzing members’...
Highlights•RSV incidence is underestimated due to infrequent testing and low-test sensitivity•We estimated RSV hospitalization incidence, accounting for undiagnosed cases•RSV-related ARI among those ≥60 years was 401.6/100,000•There a substantial burden of adults in Germany•36.4% hospitalizations older had associated cardiovascular eventsAbstractBackgroundRSV leading cause ARI, including CAP, adults. Data available often underestimate incidence. We RSV-related from prospective CAP study,...
Background: Estimating attributable risk (AR) through self-controlled case series (SCCS) analyses alone may limit generalizability because SCCS only incorporate vaccinated patients with the outcome (e.g., Guillain-Barre syndrome [GBS]) who differ from overall population recommended for vaccination. Objective: We aimed to demonstrate background event incidence rates' impact on vaccine-specific GBS ARs and standardize across different vaccine studies by applying a generalizable,...
Background Fuzheng Jiedu (FZJD) granules are widely used to treat coronavirus disease (COVID-19) since their market approval, but clinical effectiveness remains uncertain. In this study, we aimed evaluate the of FZJD in reducing progression high-risk adults with COVID-19. Methods A multicenter, retrospective cohort study involving non-severe COVID-19 was conducted China from May 2021 December 2022. The registered at Chinese Clinical Trial Registry (ChiCTR2200058097;...