A5075087643- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Bacterial Infections and Vaccines
- Influenza Virus Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Vector-borne infectious diseases
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- Mosquito-borne diseases and control
- SARS-CoV-2 detection and testing
- Virology and Viral Diseases
- Immunodeficiency and Autoimmune Disorders
- Streptococcal Infections and Treatments
- Hepatitis B Virus Studies
- COVID-19 and Mental Health
- Nosocomial Infections in ICU
- Salmonella and Campylobacter epidemiology
- Emergency and Acute Care Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gastroesophageal reflux and treatments
- Neonatal and Maternal Infections
Pfizer (United States)
2016-2025
Global Vaccines (United States)
2024-2025
Harvard University
2023
Brigham and Women's Hospital
2023
Harvard Pilgrim Health Care
2023
Johns Hopkins Medicine
2023
Johns Hopkins University
2023
Pfizer (United Kingdom)
2023
GlaxoSmithKline (United States)
2023
Pfizer (China)
2022
There is an urgent public health need to evaluate disease severity in adults hospitalised with Delta and Omicron SARS-CoV-2 variant infections. However, limited data exist assessing of infections, what extent patient-factors, including vaccination, age, frailty pre-existing disease, affect variant-dependent severity.A prospective cohort study (≥18 years age) acute lower respiratory tract at care hospitals Bristol, UK conducted over 10-months. or infection was defined by positive PCR...
BackgroundOn Dec 20, 2020, Israel initiated a nationwide COVID-19 vaccination campaign for people aged 16 years and older exclusively used the Pfizer–BioNTech BNT162b2 mRNA vaccine (tozinameran). We provide estimates of number SARS-CoV-2 infections COVID-19-related admissions to hospital (ie, hospitalisations) deaths averted by campaign.MethodsIn this retrospective surveillance study, we national data routinely collected Israeli Ministry Health from first 112 days (Dec up our cutoff April...
Abstract Determining whether SARS-CoV-2 exhibits seasonality like other respiratory viruses is critical for public health planning. We evaluated COVID-19 rates follow a seasonal pattern using time series models. used decomposition to extract the annual component of case, hospitalization, and mortality from March 2020 through December 2022 United States Europe. Models were adjusted country-specific stringency index account confounding by various interventions. Despite year-round disease...
In the USA, oral nirmatrelvir-ritonavir is authorised for use in patients aged 12 years or older with mild-to-moderate COVID-19 who are at risk of progression to severe disease and hospitalisation. We aimed establish effectiveness preventing hospital admissions death people an outpatient prescribing context USA.
Nearly all existing respiratory syncytial virus (RSV) incidence estimates are based on real-time polymerase chain reaction (RT-PCR) testing of nasal or nasopharyngeal (NP) swabs. Adding additional specimen types to NP swab RT-PCR increases RSV detection. However, prior studies only made pairwise comparisons and the synergistic effect adding multiple has not been quantified. We compared diagnosis by alone versus plus saliva, sputum, serology.This was a prospective cohort study over two...
BackgroundXBB-related omicron sublineages have recently replaced BA.4/5 as the predominant in USA and other regions globally. Despite preliminary signs of immune evasion XBB sublineages, few data exist describing real-world effectiveness bivalent COVID-19 vaccines, especially against XBB-related illness. We aimed to investigate Pfizer-–BioNTech BNT162b2 vaccine both BA.4/5-related disease adults aged 18 years or older.MethodsIn this test-negative case–control study, we estimated using from...
ABSTRACT Background RSV detection improves if an additional specimen is collected, but the impact of testing saliva and multiple types has not been assessed. We quantified increase with collection over nasopharyngeal swab (NPS) alone. Methods Prospectively enrolled hospitalized adults aged ≥40 years acute respiratory illness in seven hospitals US Canada had NPS, saliva, sputa, acute/convalescent sera collected tested. Results Among 3,669 participants, 100% 97.7% 33.0% sputum, 33.4% paired...
Using a test-negative design, we modeled the association between receipt of BNT162b2 KP.2 vaccine and symptomatic COVID-19 among adults testing for SARS-CoV-2 at walk-in clinics in large US retail pharmacy chain (9/5/2024-12/8/2024). At median 37 days post-vaccination, those who received were 48% less likely to test positive.
Abstract Little is known about the causes of enteric fever in Asia. Most cases are believed to be caused by Salmonella enterica serovar Typhi and remainder S. Paratyphi A. We compared their incidences using standardized methods from population-based studies China, Indonesia, India, Pakistan.
Abstract Background Following universal recommendation for use of 13-valent pneumococcal conjugate vaccine (PCV13) in US adults aged ≥65 years September 2014, we conducted the first real-world evaluation PCV13 effectiveness (VE) against hospitalized vaccine-type community-acquired pneumonia (CAP) this population. Methods Using a test-negative design, identified cases and controls from population-based surveillance study Louisville, Kentucky, who were with CAP. We analyzed subset CAP patients...
Abstract Background While secondary pneumococcal pneumonia occurs less commonly after coronavirus disease 2019 (COVID-19) than other viral infections, it remains unclear whether interactions occur between severe acute respiratory syndrome 2 (SARS-CoV-2) and Streptococcus pneumoniae. Methods We probed potential these pathogens among adults aged ≥65 years by measuring associations of COVID-19 outcomes with vaccination (13-valent conjugate vaccine [PCV13] 23-valent polysaccharide [PPSV23])....
Abstract Background The introduction and adoption of pneumococcal conjugate vaccines (PCVs) into pediatric national immunization programs (NIPs) has led to large decreases in invasive disease (IPD) incidence caused by vaccine serotypes. Despite these reductions, the global IPD burden children remains significant. Methods We collected serotype-specific data from surveillance systems or hospital networks all 30 high-income countries that met inclusion criteria. Data sources included online...
BackgroundAlthough recent epidemiological data suggest that pneumococci may contribute to the risk of SARS-CoV-2 disease, cases coinfection with Streptococcus pneumoniae in patients coronavirus disease 2019 (COVID-19) during hospitalization have been reported infrequently. This apparent contradiction be explained by interactions severe acute respiratory syndrome 2 (SARS-CoV-2) and upper airway, resulting escape from protective host immune responses.MethodsHere, we investigated relationship...