A5103247622- Clinical Nutrition and Gastroenterology
- Child Nutrition and Feeding Issues
- Nutrition and Health in Aging
- Pregnancy and Medication Impact
- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Anomalies and Fetal Surgery
- Pregnancy and preeclampsia studies
- Pharmacological Effects and Toxicity Studies
- Infant Nutrition and Health
- Intestinal Malrotation and Obstruction Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Digestive system and related health
- Migraine and Headache Studies
- Epilepsy research and treatment
- Metabolism and Genetic Disorders
- Child Nutrition and Water Access
- Childhood Cancer Survivors' Quality of Life
- Gestational Diabetes Research and Management
- Respiratory Support and Mechanisms
- Liver Disease Diagnosis and Treatment
- Sympathectomy and Hyperhidrosis Treatments
- Celiac Disease Research and Management
- Body Composition Measurement Techniques
- Intensive Care Unit Cognitive Disorders
- Liver Disease and Transplantation
Pfizer (United States)
2025
University College London
2012-2023
Great Ormond Street Hospital for Children NHS Foundation Trust
2014-2023
Great Ormond Street Hospital
2011-2022
Wright State University
2022
Dayton Children's Hospital
2021
Prince Charles Hospital
2021
Harvard University
2014-2020
Dalhousie University
2016-2020
Canadian Sleep Society
2020
<h3>Importance</h3> Between 0.3% and 0.5% of all pregnancies occur among women with epilepsy. Evidence suggests an increase in perinatal morbidity mortality However, these risks have not been quantified large population-based samples. <h3>Objective</h3> To report on the risk for death adverse outcomes at time delivery epilepsy United States. <h3>Design, Setting, Participants</h3> Retrospective cohort study pregnant identified through hospitalization records from 2007-2011 Nationwide...
Abstract Purpose The purpose of the study is to develop an algorithm identify pregnancies in administrative databases and apply it assess pregnancy rates outcomes women prescribed isotretinoin or tretinoin. Methods Using 2011 2015 Truven Health MarketScan Database, we identified pregnancies, including losses terminations. In a cohort design, nonpregnant filling prescription for tretinoin were matched five without either prescription. Women followed 365 days until conception, medication...
Despite a call to study the effect of weight gain pattern on development gestational diabetes mellitus, few studies have correctly adjusted for independent effects after first trimester. We used conditional percentile approach model association between and second trimester trajectories diabetes.We sampled women delivering singleton infants from 1998 2010 at Magee-Womens Hospital in Pittsburgh, PA, (n = 124,590) using case-cohort design. modeled trimesters pregnancy percentiles, multivariable...
To assess whether first-trimester exposure to pregabalin is associated with an increased risk of major congenital malformations, as recently suggested in a pregnancy registry study.We performed cohort study nested the US Medicaid Analytic eXtract (MAX). The population included 1,323,432 pregnancies resulting live-born infant between 2000 and 2010. We examined malformations among infants born women exposed during first trimester compared unexposed anticonvulsants. used propensity score fine...
<h3>Background</h3> Despite extensive knowledge regarding the effect of pulmonary exacerbations treated with intravenous antibiotics on clinical outcomes in cystic fibrosis (CF), there is little known about role milder oral (oPEx). <h3>Methods</h3> This was a retrospective cohort study patients CF followed at Hospital for Sick Children and St. Michael9s from 2009 to 2014. We evaluated oPEx short-term as proportion events which 100% or 90% baseline FEV<sub>1</sub>% predicted recovered end...
Few studies have assessed the risk of adverse pregnancy outcomes in women with multiple sclerosis (MS). We used 2 large US administrative databases, Truven Health MarketScan Database (2011–2015; Analytics Inc., Ann Arbor, Michigan) and Nationwide Inpatient Sample (2007–2011), to identify delivery cohorts. MS (infections, cesarean delivery, preterm poor fetal growth, preeclampsia, chorioamnionitis, postpartum hemorrhage, stillbirth, infant malformations) were identified during at delivery....
<h3>Objective and aim</h3> Liver disease is a potentially life-threatening complication of intravenous/parenteral nutrition (PN). Our aim was to determine the incidence, aetiology outcome intestinal failure-associated liver (IFALD) in hospitalised children treated with long-term PN (>27 days). <h3>Methods</h3> Over 4 years all failure (IF) patients were reviewed for possible predisposing factors age, diagnosis, lipid, sepsis, length treatment hospitalisation. Outcome measures IFALD...
Background/objectives Influenza is associated with significant morbidity and mortality, particularly for older adults. Persistent functional decline following hospitalization has important impacts on adults' wellbeing independence, but been under‐studied in relation to influenza. We aimed investigate persistent change adults admitted hospital influenza other acute respiratory illness (ARI). Design Protective observational cohort study. Setting Canadian Immunization Research Network Serious...
<h3>Importance</h3> Congenital cytomegalovirus (cCMV) has received far less clinical and public health attention as a teratogenic infection than the Zika virus epidemic. However, cCMV may be responsible for large fraction of microcephaly cases in United States. <h3>Objective</h3> To evaluate association between prevalence at birth <h3>Design, Setting, Participants</h3> This population-based cohort study included pregnant women their newborns identified 2 insurance claims databases from...
OBJECTIVE: To describe nationwide patterns in outpatient opioid dispensing after vaginal delivery. METHODS: Using the Truven Health Analytics MarketScan database, we performed a large, retrospective cohort study of commercially insured beneficiaries who underwent delivery between 2003 and 2015 were opioid-naive for 12 weeks before admission. We assessed proportion women dispensed an oral within 1 week discharge, associated median morphine milligram equivalent dose dispensed, frequency...
The aim of the study was to review long-term outcome intestinal epithelial dysplasia (IED)/tufting enteropathy (TE) patients treated with parenteral nutrition (PN) at home managed by an failure (IF) rehabilitation service.Infants presenting from 1986 2010 IF, and TE histology were retrospectively reviewed for up 30 years. Data collected included outcome, presentation, (parenteral/enteral), country residence, race, EpCAM gene, growth, bone age, occupation.Thirteen (6 boys) in Malta UK...
Abstract Purpose The purpose of this study is to describe dispensing patterns and comparative safety disease‐modifying therapies (DMTs) during pregnancy in women with multiple sclerosis (MS). Methods We identified pregnancies from the Truven Health Marketscan® Commercial Claims Encounters Database (2011‐2015) ascertained MS before delivery inpatient outpatient claims. computed proportion DMT claims around estimated risk ratios spontaneous abortion, infections, cesarean section, preterm...
Pre-existing conditions are imperfectly recorded in health care databases. We assessed whether pre-existing neurologic (epilepsy, multiple sclerosis [MS]) were differentially the presence of major obstetric outcomes (Caesarean delivery, preterm preeclampsia) delivery records. also evaluated impact differential recording on measures frequency and association between outcomes.The 2011-2014 Truven Health MarketScan® Commercial Claims Dataset was used to identify pregnancies. calculated relative...
Infants with complex medical conditions often display faltering growth due to elevated nutritional requirements, poor intake and intolerance of feeding malabsorption maldigestion. As a result their management can be extremely challenging enteral support is required. This study aimed investigate the effectiveness, tolerance acceptability specially formulated, paediatric peptide feed in infants disease signs current management.This prospective intervention investigated gastrointestinal (GI)...
Botulinum toxin type A (BoNT-A) has shown to be a safe and effective treatment for children with chronic migraines. Our study was assess the efficacy of Onabotulinum at different intervals after initiation therapy. We conducted retrospective prospective analysis 34 patients children's hospital where received four rounds BoNT-A therapy migraine. Among patients, 25 (age range: 13-21 years), who responded therapy, were included in analysis. Patients standard 31 injection, 155 unit's protocol....