A5035386946- Frailty in Older Adults
- Nutrition and Health in Aging
- Health Systems, Economic Evaluations, Quality of Life
- Geriatric Care and Nursing Homes
- Health disparities and outcomes
- Dementia and Cognitive Impairment Research
- Nutritional Studies and Diet
- Global Health Care Issues
- Genetics, Aging, and Longevity in Model Organisms
- Emergency and Acute Care Studies
- COVID-19 and healthcare impacts
- Retirement, Disability, and Employment
- Physical Activity and Health
- Musculoskeletal pain and rehabilitation
- Hormonal and reproductive studies
- Cardiovascular Effects of Exercise
- Muscle metabolism and nutrition
- Pressure Ulcer Prevention and Management
- Nursing education and management
- Work-Family Balance Challenges
- Elder Abuse and Neglect
- Therapeutic Uses of Natural Elements
- Intimate Partner and Family Violence
- Child and Adolescent Psychosocial and Emotional Development
- Health, psychology, and well-being
Nova Scotia Health Authority
2016-2025
Dalhousie University
2017-2025
MRC Unit for Lifelong Health and Ageing
2017
University College London
2017
Mount Saint Vincent University
2013-2017
Izaak Walton Killam Health Centre
2017
Consortium canadien en neurodégénérescence associée au vieillissement
2016
University of Toronto
2013
University of Connecticut
2001
Abstract Although many common diseases occur mostly in old age, the impact of ageing itself on disease risk and expression often goes unevaluated. To consider requires some useful means measuring variability health animals same age. In humans, this has been quantified by counting age-related deficits a frailty index. Here we show results extending that approach to mice. Across life course, important features deficit accumulation are present both species. These include gradual rates (slope =...
Abstract Background Parallel to growth of aging and obese populations, the prevalence metabolic diseases is rising. How body mass index (BMI) relates frailty mortality across levels controversial. We examined associations high BMI with explored effects percent fat on these associations. Methods included 29,937 participants aged ≥50 years from 2001–2006 National Health Nutrition Examination Survey (NHANES) cohorts ( N =6062; 53.7% females) wave 1 (2004) Health, Ageing Retirement in Europe...
Abstract Background Beyond intakes of total energy and individual nutrient, eating patterns may influence health, thereby the risk adverse outcomes. How different diet measures relate to frailty—a general measure increased vulnerability unfavorable health outcomes—and mortality risk, how this might vary across life course, is not known. We investigated associations five dietary indices (Nutrition Index (NI), energy-density Dietary Inflammatory (E-DII™), Healthy Eating Index-2015 (HEI-2015),...
<h3>BACKGROUND:</h3> Sedentary behaviours are associated with adverse health outcomes in middle-aged and older adults, even among those who exercise. We examined whether the degree of frailty affects association between sedentary higher risk mortality. <h3>METHODS:</h3> In this prospective cohort study, we used data from 3141 community-dwelling adults 50 years age or 2003/04 2005/06 cohorts US National Health Nutrition Examination Survey. Time engaged was measured using uniaxial...
Background: Frailty has been considered an antecedent and, to a lesser extent, outcome of cognitive impairment. Both frailty and impairment are multiply determined each is strongly related age, making it likely that the two interact, especially as people age. In consequence, und erstanding their interaction co-occurrence can offer insight into pathophysiology, prevention, management. Objective: To examine nature relationship between using longitudinal data from Survey Health Aging Retirement...
Abstract Background Clinically meaningful change (CMC) for frailty index (FI) scores is little studied. We estimated the CMC by associating changes in FI with Clinical Frailty Scale (CFS) hospitalized patients. Methods The Serious Outcomes Surveillance Network of Canadian Immunization Research enrolled older adults (65+ years) admitted to hospital acute respiratory illness (mean age = 79.6 ± 8.4 years; 52.7% female). Patients were assigned CFS and 39-item in-person at admission via telephone...
Background/objectives Influenza is associated with significant morbidity and mortality, particularly for older adults. Persistent functional decline following hospitalization has important impacts on adults' wellbeing independence, but been under‐studied in relation to influenza. We aimed investigate persistent change adults admitted hospital influenza other acute respiratory illness (ARI). Design Protective observational cohort study. Setting Canadian Immunization Research Network Serious...
frailty is a public health priority now that the global population ageing at rapid rate. A scientifically sound tool to measure and generate population-based reference values starting point.in this report, our objectives were operationalize as deficit accumulation using standard index (FI), describe levels of in Canadians ≥45 years old provide national normative data.this secondary analysis Canadian Longitudinal Study on Aging (CLSA) baseline data.about 51,338 individuals (weighted represent...
We examined frailty as a predictor of recovery in older adults hospitalized with influenza and acute respiratory illness.A total 5011 patients aged ≥65 years were admitted to Canadian Serious Outcomes Surveillance Network hospitals during the 2011/2012, 2012/2013, 2013/2014 seasons. Frailty was measured using previously validated index (FI). Poor defined death by 30 days postdischarge or an increase more than 0.06 (≥2 persistent new health deficits) on FI. Multivariable logistic regression...
Consistent and reproducible estimates of the underlying true level frailty are essential for risk stratification monitoring health changes. The purpose this study is to examine reliability index (FI).
Abstract The frailty index (FI) uses a deficit accumulation approach to derive single, comprehensive, and replicable indicator of age-related health status. Yet, many researchers continue seek single “frailty biomarker” facilitate clinical screening. We investigated the prognostic accuracy 70 individual biomarkers in predicting mortality, comparing each with composite FI. A total 29,341 individuals from comprehensive cohort Canadian Longitudinal Study on Aging were included (mean, 59.4 ± 9.9...
Abstract Background Worldwide population ageing is motivating how to measure the health of populations. One approach compare dynamics frailty, assessed by cumulative-deficit frailty index, across different We aim distribution, mortality risk, and change in over time between 18 countries. Methods Using data from five harmonised international surveys (HRS, SHARE, ELSA, CHARLS MHAS) we with a 40-item index (baseline, 2-, 4- 6-year follow-up), along status. constructed separate regression models...
Background: As cognitive decline mostly occurs in late life, where typically it co-exists with many other ailments, is important to consider frailty understanding change. Objective: Here, we examined the association of change status trajectories a well-s tudied cohort older Japanese-American men. Methods: Using prospective Honolulu-Asia Aging Study (HAAS), 2,817 men Japanese descent were followed (aged 71–93 at baseline). Starting 1991 follow-up health assessments every two three years,...
Standardized frailty assessments are needed for early identification and treatment. We aimed to develop a scale using visual images, the Pictorial Fit-Frail Scale (PFFS), examine its feasibility content validity.In Phase 1, multidisciplinary team identified domains measurement, operationalized impairment levels, reviewed languages scale. In 2, feedback was sought from health professionals general public. 3, 366 participants completed preliminary testing on revised draft, including 162 UK...
Abstract Background Frailty can be operationalised using the deficit accumulation approach, which considers health deficits across multiple domains. We aimed to develop, validate and compare three different frailty indices (FI) constructed from self-reported measures (FI-Self Report), blood-based biomarkers (FI-Blood) examination-based assessments (FI-Examination). Methods Up 30,027 participants aged 45–85 years baseline (2011–2015) comprehensive cohort of Canadian Longitudinal Study on...
Abstract Main Problem Frailty is an established risk factor for cognitive decline and Alzheimer's disease. Few studies have examined the longitudinal relationship between frailty cognition. Methods Participants of Rush Memory Aging project ( n = 625, 67.5% female, 83.2 ± 5.9 years at baseline) underwent annual clinical evaluations (average follow‐up 5.6 3.7 years) followed by neuropathologic assessment after death. A index was calculated from 41 health variables each evaluation. Clinical...
To determine whether cynicism changes over time as a function of job change for nurses with high and low intentions to leave.Cynicism develops in reaction organisational events including leaders' actions can result costly passive withdrawal behaviours.Hospital staff (n = 436) completed survey assessing their leave the then follow-up surveys 1 or 2 years later. Hierarchical linear modelling was used examine effect interaction between intention leave, on cynicism.Nurses who left hospital...
ABSTRACTBackground:How cognitive impairment and frailty combine to impact on older adults' Quality of Life (QoL) is little studied, but their inter-relationships are important given how often they co-occur. We sought examine impairment, as well changes in cognition, associated with QoL these relationships differ based employment status social circumstances.Using the Survey Health, Ageing, Retirement Europe data, we employed moderated regression, followed by simple slopes analysis, between...
Abstract Background Physical activity (PA) interventions may reduce the burden of frailty and can prevent mobility disability for older adults. We explored whether a 2‐year PA intervention would improve trajectory, lead to clinically meaningful changes (CMC), or impact major (MMD) across baseline levels. Methods analyzed data 1635 community‐dwelling participants who were 70–89 years old (mean age [SD]: 78.9 [5.2] years, 67.2% female) from Lifestyle Interventions Independence Study....
To examine the association of lifestyle behaviours (LSB) with physical activity (PA) and frailty; also, to if associations differ by sex age.
Background The construct of social vulnerability attempts to understand circumstances not merely as a descriptor, but predictor adverse health events. It can be measured by aggregating deficits in index (SVI). We describe standard procedure for constructing multi-level SVI using two working examples. Methods First, we six-step approach SVI. Then, conducted secondary analysis clinical dataset (Canadian Immunization Research Network’s Serious Outcomes Surveillance Network (SOS)) and...