A5060945402- Nutrition and Health in Aging
- Physical Activity and Health
- Frailty in Older Adults
- Obesity, Physical Activity, Diet
- Health disparities and outcomes
- Balance, Gait, and Falls Prevention
- Health, Environment, Cognitive Aging
- Injury Epidemiology and Prevention
- Health Systems, Economic Evaluations, Quality of Life
- Trauma and Emergency Care Studies
- Pelvic and Acetabular Injuries
- Birth, Development, and Health
- Abdominal Trauma and Injuries
- Cardiovascular and exercise physiology
- Cerebral Palsy and Movement Disorders
- Scoliosis diagnosis and treatment
- Nutritional Studies and Diet
- Health and Lifestyle Studies
- Blood Pressure and Hypertension Studies
- Health, psychology, and well-being
- Infant Development and Preterm Care
- Emergency and Acute Care Studies
- Global Health Care Issues
- Occupational and environmental lung diseases
- Optimism, Hope, and Well-being
University College London
2017-2025
Dalhousie University
2014-2024
English Institute of Sport
2021-2024
Nova Scotia Health Authority
2024
UCL Biomedical Research Centre
2024
National Institute for Health Research
2024
MRC Unit for Lifelong Health and Ageing
2017-2022
Rauma Group (Norway)
2021
University of KwaZulu-Natal
2021
West Midlands Deanery
2020
Abstract Although many common diseases occur mostly in old age, the impact of ageing itself on disease risk and expression often goes unevaluated. To consider requires some useful means measuring variability health animals same age. In humans, this has been quantified by counting age-related deficits a frailty index. Here we show results extending that approach to mice. Across life course, important features deficit accumulation are present both species. These include gradual rates (slope =...
Vigorous physical activity (VPA) is a time-efficient way to achieve recommended (PA) for cancer prevention, although structured longer bouts of VPA (via traditional exercise) are unappealing or inaccessible many individuals.To evaluate the dose-response association device-measured daily vigorous intermittent lifestyle (VILPA) with incident cancer, and estimate minimal dose required risk reduction 50% maximum reduction.This was prospective cohort analysis 22 398 self-reported nonexercising...
Abstract Background and Aims Physical inactivity, sedentary behaviour (SB), inadequate sleep are key behavioural risk factors of cardiometabolic diseases. Each is mainly considered in isolation, despite clear biological interdependencies. The aim this study was to investigate associations five-part movement compositions with adiposity biomarkers. Methods Cross-sectional data from six studies (n = 15 253 participants; five countries) the Prospective Activity, Sitting Sleep consortium were...
A frailty index (FI) based entirely on common clinical and laboratory tests might offer scientific advantages in understanding ageing pragmatic screening. Our main objective was to compare an FI with self-reported data; we additionally investigated if the combination of subclinical deficits ones increased ability predict mortality. In this secondary analysis 2003-2004 2005-2006 National Health Nutrition Examination Survey data, 8888 individuals aged 20+ were evaluated. Three FIs constructed:...
Background: abnormal laboratory test results accumulate with age and can be common in people few clinically detectable health deficits. A frailty index (FI) based entirely on physiological tests (FI-Lab) might offer pragmatic scientific advantages compared a clinical FI (FI-Clin). Objectives: to compare the FI-Lab FI-Clin assess their individual combined relationships mortality other adverse outcomes. Design subjects: secondary analysis of eight-centre, longitudinal European Male Ageing...
Nutritional status and individual nutrients have been associated with frailty in older adults. The extent to which these associations hold younger people, by type of malnutrition or grades frailty, is unclear. Our objectives were (1) evaluate the relationship between nutrition-related parameters (2) investigate association mortality across levels, (3) examine whether combining an index predicts risk levels.This observational study assembled 9030 participants aged ≥ 20 years from 2003-2006...
BackgroundWith an ageing population, the number of people with frailty is increasing. Despite this trend, extent to which severity and lethality have changed over time not well understood. We aimed investigate how 18-year period in USA.MethodsIn population-based observational study, we used data from National Health Nutrition Examination Survey (NHANES) identify community-dwelling individuals (aged ≥20 years) USA between 1999 2018. analysed a series ten 2-year, nationally representative,...
Abstract Aims/hypothesis The aim of this study was to examine the dose–response associations device-measured physical activity types and postures (sitting standing time) with cardiometabolic health. Methods We conducted an individual participant harmonised meta-analysis 12,095 adults (mean ± SD age 54.5±9.6 years; female participants 54.8%) from six cohorts thigh-worn accelerometry data Prospective Physical Activity, Sitting Sleep (ProPASS) Consortium. Associations daily walking, stair...
<h3>BACKGROUND:</h3> Sedentary behaviours are associated with adverse health outcomes in middle-aged and older adults, even among those who exercise. We examined whether the degree of frailty affects association between sedentary higher risk mortality. <h3>METHODS:</h3> In this prospective cohort study, we used data from 3141 community-dwelling adults 50 years age or 2003/04 2005/06 cohorts US National Health Nutrition Examination Survey. Time engaged was measured using uniaxial...
Abstract Past studies on how blood glucose levels vary across the menstrual cycle have largely shown inconsistent results based limited draws. In this study, 49 individuals wore a Dexcom G6 continuous monitor and Fitbit Sense smartwatch while measuring their hormones self-reporting characteristics of cycles daily. The average duration participation was 79.3 ± 21.2 days, leading to total 149 554 phases in our dataset. We use periodic restricted cubic splines evaluate relationship between...
Background Movement behaviours (eg, sedentary behaviour (SB), moderate and vigorous physical activity (MVPA), light intensity (LIPA) sleep) are linked to cognition, yet the relative importance of each component is unclear, not explored with compositional methodologies. Objective To (i) assess associations different components daily movement participant’s overall memory executive function, (ii) understand individual for cognition. Methods The 1970 British Cohort Study (BCS70) a prospective...
ABSTRACT Purpose The aim of the study was to assess influence menstrual cycle phase on injury incidence, severity and type in elite female professional footballers over three seasons. Methods Time-loss injuries data were prospectively recorded for 26 football players across categorised into four phases using a standardised model: menstruation (phase 1; P1), remainder follicular 2; P2), early luteal 3; P3), pre-menstrual 4; P4). Injury incidence rates (IRR) ratios (IIRR) calculated overall...
Current research suggests that menstruating female athletes might be at greater risk of musculoskeletal injury in relation to hormonal changes throughout the menstrual cycle. A separate body work spatial cognition also fluctuate a similar manner. Changes could, theory, contributing factor for injury, especially fast-paced sports require precise, millisecond accuracy interactions with moving objects environment. However, existing theories surrounding causes increased females largely focus on...
Abstract The frailty index (FI) uses a deficit accumulation approach to derive single, comprehensive, and replicable indicator of age-related health status. Yet, many researchers continue seek single “frailty biomarker” facilitate clinical screening. We investigated the prognostic accuracy 70 individual biomarkers in predicting mortality, comparing each with composite FI. A total 29,341 individuals from comprehensive cohort Canadian Longitudinal Study on Aging were included (mean, 59.4 ± 9.9...
BACKGROUND: Blood pressure (BP)–lowering effects of structured exercise are well-established. Effects 24-hour movement behaviors captured in free-living settings have received less attention. This cross-sectional study investigated associations between a behavior composition comprising 6 parts (sleeping, sedentary behavior, standing, slow walking, fast and combined exercise-like activity [eg, running cycling]) systolic BP (SBP) diastolic (DBP). METHODS: Data from thigh-worn accelerometers...