A5058744331- Infant Nutrition and Health
- Metabolism and Genetic Disorders
- Neonatal Respiratory Health Research
- Intestinal Malrotation and Obstruction Disorders
- Clinical Nutrition and Gastroenterology
- Esophageal and GI Pathology
- Congenital Anomalies and Fetal Surgery
- Congenital Diaphragmatic Hernia Studies
- Mitochondrial Function and Pathology
- Tissue Engineering and Regenerative Medicine
- Appendicitis Diagnosis and Management
- Diet and metabolism studies
- Tracheal and airway disorders
- Anesthesia and Neurotoxicity Research
- Electrospun Nanofibers in Biomedical Applications
- Hernia repair and management
- Chronic Disease Management Strategies
- Pediatric Hepatobiliary Diseases and Treatments
- Abdominal Surgery and Complications
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Peroxisome Proliferator-Activated Receptors
- Child Nutrition and Feeding Issues
- Intestinal and Peritoneal Adhesions
- Urological Disorders and Treatments
- Cardiac Ischemia and Reperfusion
University College London
2016-2025
Great Ormond Street Hospital
2016-2025
ERN GUARD-Heart
2023-2024
ERNICA
2023-2024
Erasmus MC - Sophia Children’s Hospital
2023-2024
Ormond (United States)
2024
Erasmus MC
2023
UCL Biomedical Research Centre
2020-2023
Institute of Child Health
1998-2022
Eaton (Taiwan)
2019-2022
To evaluate the effectiveness of a structured group education programme on biomedical, psychosocial, and lifestyle measures in people with newly diagnosed type 2 diabetes.Multicentre cluster randomised controlled trial primary care randomisation at practice level.207 general practices 13 sites United Kingdom.824 adults (55% men, mean age 59.5 years).A for six hours delivered community by two trained healthcare professional educators compared usual care.Haemoglobin A(1c) levels, blood...
The differentiation of IL-10-producing regulatory B cells (Bregs) in response to gut-microbiota-derived signals supports the maintenance tolerance. However, whether microbiota-derived metabolites can modulate Breg suppressive function remains unknown. Here, we demonstrate that rheumatoid arthritis (RA) patients and arthritic mice have a reduction microbial-derived short-chain fatty acids (SCFAs) compared healthy controls mice, supplementation with SCFA butyrate reduces severity. Butyrate...
Organoids have extensive therapeutic potential and are increasingly opening up new avenues within regenerative medicine. However, their clinical application is greatly limited by the lack of effective GMP-compliant systems for organoid expansion in culture. Here, we envisage that use extracellular matrix (ECM) hydrogels derived from decellularized tissues (DT) can provide an environment capable directing cell growth. These gels possess biochemical signature tissue-specific ECM translation....
The aim of this study was to evaluate the feasibility and safety nonoperative treatment acute nonperforated appendicitis with antibiotics in children.A pilot randomized controlled trial performed comparing versus surgery for children. Patients imaging-confirmed who would normally have had emergency appendectomy were either or surgery. Follow-up 1 year.Fifty patients enrolled; 26 24 antibiotics. All children group histopathologically confirmed appendicitis, there no significant complications...
Abstract Although manganese is an essential trace metal, little known about its transport and homeostatic regulation. Here we have identified a cohort of patients with novel autosomal recessive transporter defect caused by mutations in SLC39A14. Excessive accumulation these results rapidly progressive childhood-onset parkinsonism–dystonia distinctive brain magnetic resonance imaging appearances neurodegenerative features on post-mortem examination. We show that SLC39A14 impair vitro lead to...
Transforming care for people with long term conditions, including support self management, requires comprehensive reform of health systems largely geared to provide acute care. <b>Simon Eaton</b>, <b>Sue Roberts</b>, and <b>Bridget Turner</b> explore the barriers change, arguing that success new approaches will depend on whole system change strong leadership
The urea cycle enzyme argininosuccinate lyase (ASL) enables the clearance of neurotoxic ammonia and biosynthesis arginine. Patients with ASL deficiency present argininosuccinic aciduria, an inherited metabolic disease hyperammonemia a systemic phenotype coinciding neurocognitive impairment chronic liver disease. Here, we describe dysregulation glutathione upstream cysteine utilization in ASL-deficient patients mice using targeted metabolomics vivo positron emission tomography (PET) imaging (...
Abstract Nutritional epidemiology aims to link dietary exposures chronic disease, but the instruments for evaluating intake are inaccurate. One way identify unreliable data and sources of errors is compare estimated intakes with total energy expenditure (TEE). In this study, we used International Atomic Energy Agency Doubly Labeled Water Database derive a predictive equation TEE using 6,497 measures in individuals aged 4 96 years. The resultant regression predicts expected from easily...
A female infant of nonconsanguineous Indian parents presented at 4 months with a hypoglycemic convulsion. Further episodes hypoketotic hypoglycemia were associated inappropriately elevated plasma insulin concentrations. However, unlike other children hyperinsulinism, this patient had persistently blood spot hydroxybutyrylcarnitine concentration when fed, as well fasted. Measurement the activity L-3-hydroxyacyl-CoA dehydrogenase in cultured skin fibroblasts acetoacetyl-CoA substrate showed...
A female infant of nonconsanguineous Indian parents presented at 4 months with a hypoglycemic convulsion. Further episodes hypoketotic hypoglycemia were associated inappropriately elevated plasma insulin concentrations. However, unlike other children hyperinsulinism, this patient had persistently blood spot hydroxybutyrylcarnitine concentration when fed, as well fasted. Measurement the activity L-3-hydroxyacyl-CoA dehydrogenase in cultured skin fibroblasts acetoacetyl-CoA substrate showed...
We have reviewed all known UK cases of Smith-Lemli-Opitz syndrome. Among 49 with proven 7-dehydrocholesterol reductase deficiency, half had been terminated or died in infancy. The minimum incidence is 1 60,000. frequent occurrence hypospadias may account for 71% recognised being male. Important common features which emerged include short thumbs, severe photosensitivity, aggressive behaviour, and atrioventricular septal defect. typical facial appearance becomes less obvious age 20% did not...
In Brief Objective: To determine whether primary peritoneal drainage improves survival and outcome of extremely low birth weight (ELBW) infants with intestinal perforation. Summary Background Data: Optimal surgical management ELBW perforation is unknown. Methods: An international multicenter randomized controlled trial was performed between 2002 2006. Inclusion criteria were birthweight ≤1000 g pneumoperitoneum on x-ray (necrotizing enterocolitis or isolated perforation). Patients to drain...
Management of intestinal failure remains a clinical challenge and total parenteral nutrition, elongation and/or transplantation are partial solutions. In this study, using detergent-enzymatic treatment (DET), we optimize in rats new protocol that creates natural scaffold, as base for developing functional tissue. After 1 cycle DET, histological examination SEM TEM analyses showed removal cellular elements with preservation the native architecture connective tissue components. Maintenance...
Abstract Aims To assess the prevalence of and risk factors for autonomic neuropathy in EURODIAB IDDM Complications Study. Methods The study involved examination randomly selected Type I (insulin‐dependent) diabetic patients from 31 centres 16 European countries. Neuropathic symptoms two tests function (changes heart rate blood pressure lying to standing) were assessed data 3007 available present analysis. Autonomic was defined as an abnormality at least one tests. Results 36% with no sex...
The Ketogenic diet (KD) is an effective treatment with regards to treating pharmaco-resistant epilepsy. However, there are difficulties around compliance and tolerability. Consequently, a need for refined/simpler formulations that could replicate the efficacy of KD. One proposed hypotheses KD increases cellular mitochondrial content which results in elevation seizure threshold. Here, we have focussed on medium-chain triglyceride form observation plasma octanoic acid (C8) decanoic (C10)...