Annemiek M. Joosen
A5044600553- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Body Composition Measurement Techniques
- Peroxisome Proliferator-Activated Receptors
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Meat and Animal Product Quality
- Physical Activity and Health
- Electrolyte and hormonal disorders
- Tea Polyphenols and Effects
- Liver Disease Diagnosis and Treatment
- Clinical Nutrition and Gastroenterology
- Isotope Analysis in Ecology
- Behavioral Health and Interventions
- Acute Myeloid Leukemia Research
- Hematological disorders and diagnostics
- Thermoregulation and physiological responses
- Metabolomics and Mass Spectrometry Studies
- Biochemical Analysis and Sensing Techniques
- Agriculture Sustainability and Environmental Impact
- Pituitary Gland Disorders and Treatments
- Hemoglobinopathies and Related Disorders
Maastricht University Medical Centre
2014-2025
Maastricht University
2005-2023
Máxima Medisch Centrum
2022-2023
Radboud University Nijmegen
2022-2023
Amphia Ziekenhuis
2014-2018
Sint Franciscus Gasthuis
2017
Cranfield University
2012-2015
Wellcome Trust
2008-2012
MRC Mitochondrial Biology Unit
2008-2012
MRC Epidemiology Unit
2010
Total daily energy expenditure ("total expenditure") reflects needs and is a critical variable in human health physiology, but its trajectory over the life course poorly studied. We analyzed large, diverse database of total measured by doubly labeled water method for males females aged 8 days to 95 years. increased with fat-free mass power-law manner, four distinct stages. Fat-free mass-adjusted accelerates rapidly neonates ~50% above adult values at ~1 year; declines slowly levels ~20...
Abstract Nutritional epidemiology aims to link dietary exposures chronic disease, but the instruments for evaluating intake are inaccurate. One way identify unreliable data and sources of errors is compare estimated intakes with total energy expenditure (TEE). In this study, we used International Atomic Energy Agency Doubly Labeled Water Database derive a predictive equation TEE using 6,497 measures in individuals aged 4 96 years. The resultant regression predicts expected from easily...
Abstract Objective : To investigate the ability of a newly developed triaxial accelerometer to predict total energy expenditure (EE) (TEE) and activity‐related EE (AEE) in free‐living conditions. Research Methods Procedures Subjects were 29 healthy subjects between ages 18 40. The Triaxial Accelerometer for Movement Registration (Tracmor) was worn 15 consecutive days. Tracmor output defined as activity counts per day (ACD) sum all three axes or each axis separately (ACD‐X, ACD‐Y, ACD‐Z). TEE...
Haem in red meat (RM) stimulates the endogenous production of mutagenic nitroso compounds (NOC). Processed (nitrite-preserved red) additionally contains high concentrations preformed NOC. In two studies, a fresh RM versus vegetarian (VEG) diet (six males and six females) nitrite-preserved (PM) VEG (5 11 females), we investigated whether processing might increase colorectal cancer risk by stimulating nitrosation DNA damage. Meat diets contained 420 g (males) or 366 (females) meat/per day....
Understanding the impacts of activity on energy balance is crucial. Increasing levels may bring diminishing returns in expenditure because compensatory responses non-activity expenditures.1Pontzer H. Durazo-Arvizu R. Dugas L.R. Plange-Rhule J. Bovet P. Forrester T.E. Lambert E.V. Cooper R.S. Schoeller D.A. Luke A. Constrained total and metabolic adaptation to physical adult humans.Curr. Biol. 2016; 26: 410-417Abstract Full Text PDF PubMed Scopus (145) Google Scholar, 2Halsey L.G. The mystery...
The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. estimated rCO2 sensitive dilution space ratio (DSR) two isotopes. Based on performance validation studies, propose a new equation based estimate mean...
Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lacks access to safe drinking water. intake requirements largely reflect water turnover (WT), the used by body each day. We investigated determinants of human WT 5604 people from ages 8 days 96 years 23 countries using isotope-tracking (
Physical activity may be a way to increase and maintain fat-free mass (FFM) in later life, similar the prevention of fractures by increasing peak bone mass.
Meat and fish consumption are associated with changes in the risk of chronic diseases. Intake is mainly assessed using self-reporting, as no true quantitative nutritional biomarker available. The measurement plasma fatty acids, often used an alternative, expensive time-consuming. As meat differ their stable isotope ratios, δ(13)C δ(15)N have been proposed biomarkers. However, they never investigated controlled human dietary intervention studies.
In mammals, trait variation is often reported to be greater among males than females. However, date, mainly only morphological traits have been studied. Energy expenditure represents the metabolic costs of multiple physical, physiological, and behavioral traits. could exhibit particularly high male through a cumulative effect if those mostly variation, or lack many them do not. Sex differences in energy little explored. We analyzed large database on adult humans (1494 3108 females)...
Abstract Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, critical variable in longitudinal studies balance, is understudied. We examine repeated doubly labeled water (DLW) measurements TEE 348 adults and 47 children from the IAEA DLW Database (mean ± SD time interval: 1.9 2.9 y) to assess if adjusted age, sex, fat-free mass, fat mass associated with changes or body composition. Here, we report that high adults, not...
The large inter-individual variation in weight gain during standardized overfeeding together with a that is often less than theoretically calculated from the energy excess suggest there are differences between persons capacity to regulate expenditure and hence metabolic efficiency. Adaptive thermogenesis defined as regulated production of heat response environmental changes temperature diet, resulting inefficiency. question whether adaptive can be identified experiments. From numerous human...
The intake of sucrose is public health concern but limited information available on the metabolic effects short-term exposure. Our aim was to use metabolomics investigate impact acute exposure.We performed a randomized, parallel, single-dose feeding study healthy females (n = 90, aged 29.9 ± 4.7 years, BMI 23.3 2.5 kg/m(2) ) consuming either 0, 50, or 100 g in 500 mL water. Blood and urine samples were taken before 24 h post intake. Urine plasma underwent detailed metabolite profiling...
N-3 polyunsaturated fatty acids have been associated with reduced colon tumorigenesis. However, their association colorectal cancer incidence is not conclusive. We investigated the influence of isocaloric replacement red meat fish on endogenous nitrosation, inflammation and genotoxicity faecal water in apparently healthy human volunteers controlled diets. Fourteen consumed a high meat, combined meat/fish diet for 8 days each. Faecal homogenates were analysed haem, nitroso compounds (NOC)...
Lower ambient temperature (T
Several epidemiological studies suggest a link between the intake of refined sugars and an increased risk for colorectal, breast, pancreatic endometrial cancer. However, other failed to confirm these conclusions reason this may be ambiguity dietary assessment methods - mainly self-reporting employed. Sucrose is established biomarker intake, allowing objective sucrose. So far, urinary excretion sucrose was determined using enzyme assay. method time-consuming labour-intensive. In study, we...