A5053506463- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Congenital Diaphragmatic Hernia Studies
- 3D Printing in Biomedical Research
- Medical Imaging and Pathology Studies
- Tissue Engineering and Regenerative Medicine
- Telomeres, Telomerase, and Senescence
- Advanced Neural Network Applications
- Domain Adaptation and Few-Shot Learning
- MicroRNA in disease regulation
- Systemic Sclerosis and Related Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammasome and immune disorders
- interferon and immune responses
- Genetics, Aging, and Longevity in Model Organisms
- Adversarial Robustness in Machine Learning
- Advanced Optical Sensing Technologies
- Computer Graphics and Visualization Techniques
- Leptospirosis research and findings
- Automotive and Human Injury Biomechanics
- Respiratory Support and Mechanisms
- Cellular and Composite Structures
- Eosinophilic Disorders and Syndromes
- 3D Shape Modeling and Analysis
- Microfluidic and Bio-sensing Technologies
University of Pittsburgh
2022-2024
Pulmonary Associates
2024
University of Pittsburgh Medical Center
2024
Helmholtz Zentrum München
2020-2023
Ludwig-Maximilians-Universität München
2020-2023
Peking University
2023
German Center for Lung Research
2020-2022
Comprehensive Urology
2020-2021
ShanghaiTech University
2018-2020
Shanghai Institutes for Biological Sciences
2018
Organoids have extensive therapeutic potential and are increasingly opening up new avenues within regenerative medicine. However, their clinical application is greatly limited by the lack of effective GMP-compliant systems for organoid expansion in culture. Here, we envisage that use extracellular matrix (ECM) hydrogels derived from decellularized tissues (DT) can provide an environment capable directing cell growth. These gels possess biochemical signature tissue-specific ECM translation....
Abstract The immunoproteasome is a specialized type of proteasome involved in MHC class I antigen presentation, antiviral adaptive immunity, autoimmunity, and also part broader response to stress. Whether the regulated by DNA stress, however, not known. We here demonstrate that mitochondrial stress upregulates presentation pathway via cGAS/STING/type interferon signaling resulting cell autonomous activation CD8 + T cells. cGAS/STING‐induced immune observed genomic conserved epithelial...
3D object detection from point clouds is crucial in safety-critical autonomous driving. Although many works have made great efforts and achieved significant progress on this task, most of them suffer expensive annotation cost poor transferability to unknown data due the domain gap. Recently, few attempt tackle gap objects, but still fail adapt varying beam-densities between two domains, which critical mitigate characteristic differences LiDAR collectors. To end, we make propose a...
The specification of the hepatic identity during human liver development is strictly controlled by extrinsic signals, yet it still not clear how cells respond to these exogenous signals activating secretory cascades, which are extremely relevant, especially in 3D self-organizing systems. Here, we investigate proteins secreted pluripotent stem (hPSCs) response developmental affect progression from endoderm lineage, including their competence generate nascent organoids. By using microfluidic...
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by progressive scarring and remodeling. Although treatments exist that slow progression, IPF irreversible, there no cure. Cellular senescence, a major hallmark of aging, has been implicated in pathogenesis, mitochondrial dysfunction increasingly recognized as driver senescence. Adenine nucleotide translocases (ANTs) are abundant ATP–ADP transporters critical for regulating cell fate maintaining function. We...
Senescent cells accumulate in aged and diseased lungs their senescence-associated secretory phenotype (SASP) has been linked to the inflammation impaired regeneration found idiopathic pulmonary fibrosis (IPF). However, molecular targets prevent or reverse senescence-mediated fibrotic changes are missing. Here, we aimed identify SASP factors involved aging-associated lung using a novel clinically relevant ex vivo model. We irradiated human precision cut-lung slices (IR-hPCLS) induce cellular...
Aging is the main risk factor for chronic lung diseases (CLDs) including idiopathic pulmonary fibrosis (IPF) and obstructive disease (COPD). Accordingly, hallmarks of aging like cellular senescence are increased in these patients different cell types fibroblasts. However, little known about triggers that induce a phenotype backgrounds its role CLD pathogenesis. Therefore, we characterized primary human fibroblasts (phLF) from control, IPF, or COPD at baseline after exposure to...
qnrD, unlike other qnr genes, is mainly located on small nonconjugative plasmids. We investigated the presence of qnrD among 1,373 Enterobacteriaceae isolates in China. Twelve qnrD-positive strains were detected, and all nonsusceptible to fluoroquinolones. The complete sequence plasmids showed that determinants two with a respective size ∼4.2 2.7 k-bp. Interestingly, identification this study revealed highest prevalence Proteeae identified.
Transcriptomic analyses have advanced the understanding of complex disease pathophysiology including chronic obstructive pulmonary (COPD). However, identifying relevant biologic causative factors has been limited by integration high dimensionality data. COPD is characterized lung destruction and inflammation with smoke exposure being a major risk factor. To define novel biological mechanisms in COPD, we utilized unsupervised supervised interpretable machine learning single cell-RNA...
Emphysema, the progressive destruction of gas exchange surfaces in lungs, is a hallmark COPD that presently incurable. This therapeutic gap largely due to poor understanding potential drivers impaired tissue regeneration, such as abnormal lung epithelial progenitor cells, including alveolar type II (ATII) and airway club cells. We discovered an emphysema-specific subpopulation ATII cells located enlarged distal sacs, termed asATII Single-cell RNA sequencing situ localisation revealed...
Autonomous driving demands high-quality LiDAR data, yet the cost of physical sensors presents a significant scaling-up challenge. While recent efforts have explored deep generative models to address this issue, they often consume substantial computational resources with slow generation speeds while suffering from lack realism. To these limitations, we introduce RangeLDM, novel approach for rapidly generating range-view point clouds via latent diffusion models. We achieve by correcting data...
Cellular senescence is a major hallmark of aging. Senescence defined as an irreversible growth arrest observed when cells are exposed to variety stressors including DNA damage, oxidative stress, or nutrient deprivation. While well-established driver aging and age-related diseases, it highly heterogeneous process with significant variations across organisms, tissues, cell types. The relatively low abundance in healthy aged tissues represents challenge studying given organ, the human lung. To...
ABSTRACT Idiopathic Pulmonary Fibrosis (IPF) is an interstitial lung disease characterized by progressive scarring and remodeling. Although treatments exist that slow progression, IPF irreversible there no cure. Cellular senescence, a major hallmark of aging, has been implicated in pathogenesis, mitochondrial dysfunction increasingly recognized as driver senescence. Adenine nucleotide translocases (ANTs) are abundant ATP-ADP transporters critical for regulating cell fate maintaining...
Abstract Idiopathic Pulmonary Fibrosis (IPF) is a progressive and fatal lung disease with limited therapeutic options. Epithelial reprogramming honeycomb cysts are key pathological features of IPF, however, the IPF distal bronchiole cell subtypes their potential contribution to development progression still remain poorly characterized. Here, we utilized single-cell RNA sequencing on enriched EpCAM + cells Donor lung. Using 10x Genomics platform, generated dataset 47,881 found distinct...
3D object detection from point clouds is crucial in safety-critical autonomous driving. Although many works have made great efforts and achieved significant progress on this task, most of them suffer expensive annotation cost poor transferability to unknown data due the domain gap. Recently, few attempt tackle gap objects, but still fail adapt varying beam-densities between two domains, which critical mitigate characteristic differences LiDAR collectors. To end, we make propose a...