A5087006612- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Congenital Diaphragmatic Hernia Studies
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical Imaging and Pathology Studies
- Air Quality and Health Impacts
- Pulmonary Hypertension Research and Treatments
- MicroRNA in disease regulation
- Connective tissue disorders research
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Air Quality Monitoring and Forecasting
- Energy and Environment Impacts
- Respiratory Support and Mechanisms
University of Groningen
2019-2023
Institute for Asthma and Allergy
2023
University Medical Center Groningen
2019-2022
University of Colorado Anschutz Medical Campus
2019-2021
University of Colorado Denver
2019-2021
Abstract Wnt/β-catenin signaling regulates progenitor cell fate decisions during lung development and in various adult tissues. Ectopic activation of promotes tissue repair emphysema, a devastating disease with progressive loss parenchymal tissue. The identity responsive cells the potential impact on distal epithelial function emphysema are poorly understood. Here, we used TCF/Lef:H2B/GFP reporter mice to investigate role organoid formation. We identified an organoid-forming population...
Chronic obstructive pulmonary disease (COPD) represents a worldwide concern with high morbidity and mortality, is believed to be associated accelerated ageing of the lung. Alveolar abnormalities leading emphysema are key characteristic COPD. Pulmonary alveolar epithelial type 2 cells (AT2) produce surfactant function as progenitors for 1 cells. Increasing evidence shows elevated WNT-5A/B expression in COPD that may contribute process. However, supportive roles lung regeneration were also...
Chronic obstructive pulmonary disease (COPD) is a progressive lung characterized by inflammation and impaired tissue regeneration, reported as the fourth leading cause of death worldwide Centers for Disease Control Prevention (CDC). Environmental pollution specifically motor vehicle emissions are known to play role in pathogenesis COPD, but little still about molecular mechanisms that altered following diesel exhaust particles (DEP) exposure. Here we used organoids derived from co-culture...
Chronic obstructive pulmonary disease (COPD) is characterized by a persistent inflammatory state in the lungs and defective tissue repair. Although response patients with COPD well known to be exaggerated during exacerbations, its contribution lung injury abnormal repair still unclear. In this study, we aimed investigate how microenvironment affects epithelial progenitors their supporting mesenchymal niche cells involved of distal lung. We focused on IL-1β, key mediator that increased...
We have previously demonstrated that HRas/NRas-double null mutant (DKO) exhibited delayed lung maturation as revealed by increased retention of alveolar progenitors and bi-potent in distal epithelium (Fuentes-Mateos et al., 2019). Primary fibroblasts from newborn pups devoid HRas and/or NRas were used to analyse whether the mesenchyme was responsible for observed defects. Our results showed lacking had a dysregulation Hox5-Wnt2-FGF7/10 pathway. To investigate relevance epithelium-mesenchymal...
<b>Introduction:</b> Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide that characterized by progressive loss alveolar tissue. Endogenous lung stem cells and tissue repair pathways are thought be dysfunctional their reactivation a promising therapeutic approach for COPD. Wnt/β-catenin signaling critical cell function reduced in human COPD lungs. We previously demonstrated initiated patient-derived <i>ex vivo</i>. Recently, we identified an epithelial...
Chronic obstructive pulmonary disease (COPD) is a progressive of the lung characterized by impaired tissue regeneration, and reported as fourth leading cause death worldwide Centers for Disease Control Prevention (CDC). Environmental pollution specifically motor vehicle emissions are known to play role in pathogenesis COPD, but little still about molecular mechanisms that altered following diesel exhaust particles (DEP) exposure. Here we used organoids derived from co-culture alveolar...
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, with limited therapeutic options available, and no treatment able to reverse progression. Importantly, immune cells infiltrating COPD lung are organized into inducible bronchus-associated lymphoid tissue (iBALT), which drives emphysema progression in humans mice. iBALT formation requires interaction lymphotoxin β receptor (LTβR) on stromal organizer TNF superfamily members α (LTα) (LTβ). Here we...
Introduction Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide that characterized by progressive loss alveolar tissue. Endogenous lung stem cells and tissue repair pathways are thought be dysfunctional their reactivation a promising therapeutic approach for COPD. Wnt/β-catenin signaling critical cell function reduced in human COPD lungs. We have previously demonstrated initiated patient-derived ex vivo. Recently, we identified an epithelial progenitor...
<b>Introduction:</b> Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide that characterized by progressive loss alveolar tissue. Endogenous lung stem cells and tissue repair pathways are thought be dysfunctional their reactivation a promising therapeutic approach for COPD. Wnt/ß-catenin signaling?is critical for?stem?cell function reduced in human COPD lungs. We previously demonstrated initiated patient-derived ex vivo. Recently, we identified an...