A5034637849- Marine animal studies overview
- Immune Response and Inflammation
- Aquaculture disease management and microbiota
- Antimicrobial Peptides and Activities
- Ocean Acidification Effects and Responses
- Sperm and Testicular Function
- Epigenetics and DNA Methylation
- Cardiovascular and Diving-Related Complications
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Venomous Animal Envenomation and Studies
- Animal Genetics and Reproduction
- Ichthyology and Marine Biology
- Congenital heart defects research
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Neonatal Respiratory Health Research
- Healthcare and Venom Research
- Neuroscience and Neuropharmacology Research
- Identification and Quantification in Food
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Bat Biology and Ecology Studies
- Glutathione Transferases and Polymorphisms
- Testicular diseases and treatments
- Neuroscience of respiration and sleep
Nanjing Normal University
2016-2025
University of Colorado Denver
2014-2022
University of Colorado Anschutz Medical Campus
2017-2020
University of Colorado System
2017
Fudan University
2006-2008
Cetaceans (whales, dolphins, and porpoises) are a group of mammals adapted to various aquatic habitats, from oceans freshwater rivers. We report the sequencing, de novo assembly analysis finless porpoise genome, re-sequencing an additional 48 individuals. use these data reconstruct demographic history porpoises their origin occupation into Yangtze River. Analyses selection between marine identify genes associated with renal water homeostasis urea cycle, such as transporter 2 angiotensin...
Nonalcoholic fatty liver disease (NAFLD) is currently one of most common forms chronic globally. NAFLD represents a wide spectrum involvement from nonprogressive isolated steatosis to nonalcoholic steatohepatitis (NASH), characterized by necroinflammation and fibrosis the top causes end-stage hepatocellular carcinoma. At present, there lack effective treatments, central barrier development therapies requirement for an invasive biopsy diagnosis NASH. Discovery reliable, noninvasive biomarkers...
Abstract Wnt/β-catenin signaling regulates progenitor cell fate decisions during lung development and in various adult tissues. Ectopic activation of promotes tissue repair emphysema, a devastating disease with progressive loss parenchymal tissue. The identity responsive cells the potential impact on distal epithelial function emphysema are poorly understood. Here, we used TCF/Lef:H2B/GFP reporter mice to investigate role organoid formation. We identified an organoid-forming population...
Five basic taste modalities, sour, sweet, bitter, salt and umami, can be distinguished by humans are fundamental for physical ecological adaptations in mammals. Molecular genetic studies of the receptor genes these tastes have been conducted terrestrial mammals; however, little is known about evolution adaptation marine Here, all five were investigated cetaceans. The sequence characteristics evolutionary analyses suggested that nearly cetaceans may lost modalities except salt. This first...
Although cetaceans (whales, porpoises, and dolphins) have multi-chambered stomachs, feeding habits of modern dramatically changed from herbivorous to carnivorous. However, the genetic basis underlying this dietary switch remains unexplored. Here, we present first systematic investigation 10 digestive enzymes genes (i.e., CYP7A1, CTRC, LIPC, LIPF, PNLIP, PGC, PRSS1, SI, SLC5A1, TMPRSS15) representative cetaceans, evolutionary trajectory RNASE1 in cetartiodactylans. Positive selections were...
Marine mammals provide a valuable model for studying the molecular basis of convergent evolution during secondary aquatic adaptation. Using multi-omics data and functional experiments, including CRISPR-Cas9 mouse models luciferase reporter assays, this study explored mechanisms driving transition across coding regions, regulatory elements, genomic architecture. Convergent amino acid substitutions in APPL1 P378L NEIL1 E71G were found to promote lipid accumulation suppress cancer cell...
The evolution of limb morphology plays an important role in animal adaptation to different ecological niches. To fully adapt aquatic life, cetaceans underwent hindlimb degeneration and forelimb transformed into flipper; however, the molecular mechanisms underlying changes remain unclear. We previous study had shown that Tbx4 enhancer A (Tbx4-HLEA) exhibited specific deletions nucleotide substitutions, with significantly reduced regulatory activity. further investigate whether cetacean HLEA...
Abstract Cetaceans are a group of secondarily adapted marine mammals with an enigmatic history transition from terrestrial to fully aquatic habitat and subsequent adaptive radiation in waters around the world. Numerous physiological morphological cetacean characteristics have been acquired response this drastic transition; for example, thickened blubber is one most striking changes that increases their buoyancy, supports locomotion provides thermal insulation. However, genetic basis...
Abstract Primary sclerosing cholangitis (PSC) is an idiopathic and heterogenous cholestatic liver disease characterized by chronic inflammation fibrosis of the biliary tree. Currently, no effective therapies are available for this condition, whose incidence rising. At present, specificity sensitivity current serum markers used to diagnose PSC limited often unreliable. In study, we characterize circulating extracellular vesicles provide supporting data on their potential use as novel...
Abstract Functional activation of NMDA receptors requires co‐activation glutamate‐ and glycine‐binding sites. d ‐serine is considered to be an endogenous ligand for the glycine site receptors. Using a combination rat formalin‐induced conditioned place avoidance (F‐CPA) behavioral model whole‐cell patch‐clamp recording in rostral anterior cingulate cortex (rACC) slices, we examined effects ‐amino acid oxidase (DAAO), ‐serine‐degrading enzyme, 7‐chlorokynurenate (7Cl‐KYNA), antagonist...
Chemotherapeutic agents, e.g., cytarabine and doxorubicin, cause DNA damage. However, it remains unknown whether such agents differentially regulate cell cycle arrest in distinct types of B-cell lymphomas, this phenotype can be exploited for developing new therapies. We treated various B cells, including primary lymphoma with or determined damage responses, regulation sensitivity to a Wee1 inhibitor. found that cyclin A2/B1 upregulation appears an intrinsic programmed response damage;...
Extreme longevity has evolved multiple times during the evolution of mammals, yet its underlying molecular mechanisms remain largely underexplored. Here, we compared 115 aging-related genes in 11 long-lived species and 25 mammals with non-increased lifespan (control group) hopes better understanding common behind longevity. We identified 16 unique positively selected 23 rapidly evolving species, which included nine involved regulating through insulin/IGF-1 signaling (IIS) pathway highly...
Background : Doxorubicin (DOX) has been one of the most effective antitumor agents against a broad spectrum malignancies. However, DOX‐induced cardiotoxicity forms major cumulative dose‐limiting factor. Glutamine and ω‐3 polyunsaturated fatty acids (PUFAs) are putatively cardioprotective during various stresses and/or have potential chemosensitizing effects cancer chemotherapy. Methods Antitumor activity DOX treatment were evaluated simultaneously in MatBIII mammary adenocarcinoma...
Abstract Background Cetaceans, having experienced prolonged adaptation to aquatic environments, have undergone evolutionary changes in their respiratory systems. This process of evolution has resulted the emergence distinctive phenotypic traits, notably abundance elastic fibers and thickened alveolar walls lungs, which may facilitate collapse during diving. structure helps selective exchange oxygen carbon dioxide, while minimizing nitrogen exchange, thereby reducing risk DCS. Nevertheless,...
Abstract Previously, we have reported that apoptosis of cerebellar granular neurons induced by incubation in 5 m K + and serum‐free medium (LK‐S) was associated with an increase the delayed rectifier current ( I ). Here, show apoptotic is mainly encoded a Kv2.1 subunit. Silencing expression small interfering RNA reduces increases neuron viability. Forskolin able to decrease amplitude recording from both LK‐S control group, prevents granule cells are LK‐S. Dibutyryl cAMP mimicks effect...
Cetacean brain size expansion is an enigmatic event in mammalian evolution, yet its genetic basis remains poorly explored. Here, all exons of the seven primary microcephaly (MCPH) genes that play key roles regulation during development were investigated representative cetacean lineages. Sequences MCPH2–7 intact cetaceans but frameshift mutations and stop codons was identified MCPH1. Extensive positive selection four six MCPH genes: WDR62, CDK5RAP2, CEP152, ASPM. Specially, at CDK5RAP2 ASPM...
Cetaceans are a group of marine mammals whose ancestors were adaptated for life on land. Life in an aquatic environment poses many challenges air-breathing mammals. Diving have adapted to rapid reoxygenation and reactive oxygen species (ROS)-mediated reperfusion injury. Here, we considered the evolution glutathione transferase (GST) gene family which has important roles detoxification endogenously-derived ROS environmental pollutants. We characterized cytosolic GST 21 mammalian species;...
A bstract Seven hundred and twenty base pairs (bp) of the mitochondrial control region from 73 finless porpoises, Neophocaena phocaenoides , in Chinese waters were sequenced. Thirteen variable sites determined 17 haplotypes defined. Of these, 5 7 found only Yellow Sea population South China population, respectively, whereas no specific haplo‐type was Yangtze River population. Phylogenetic analyses using NJ ML algorithm did not divide into monophyletic clades representing recognized...
Along with sophisticated echolocation found in bats and toothed whales, the common shrew (Sorex araneus) was confirmed to possess ability based on behavioral experimental evidence such as high-frequency twittering close-range spatial orientation. However, whether is convergent dolphins at molecular level remains poorly understood. In this study, we gathered coding region sequences of 11 hearing-related genes from genome data previous studies. Convergent evolutionary analyses identified 13...
Cetacean hindlimbs were lost and their forelimb changed into flippers characterized by webbed digits hyperphalangy, thus allowing them to adapt a completely aquatic environment. However, the underlying molecular mechanism behind cetacean limb development remains poorly understood.In present study, we explored evolution of 16 limb-related genes cis-regulatory elements in cetaceans compared with that other mammals. TBX5, specific expression gene, was identified have been under accelerated...