A5026453992- Genetic Associations and Epidemiology
- RNA modifications and cancer
- BRCA gene mutations in cancer
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Cancer, Lipids, and Metabolism
- Genetic factors in colorectal cancer
- Rheumatoid Arthritis Research and Therapies
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Marine animal studies overview
- Systemic Lupus Erythematosus Research
- Folate and B Vitamins Research
- Gene expression and cancer classification
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Helicobacter pylori-related gastroenterology studies
- Nutritional Studies and Diet
- Gastrointestinal motility and disorders
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Trace Elements in Health
- Ocean Acidification Effects and Responses
- Cancer, Hypoxia, and Metabolism
Zhejiang Chinese Medical University
2020-2024
Memorial Sloan Kettering Cancer Center
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Yantai Academy of Agricultural Sciences
2024
First Affiliated Hospital of Zhengzhou University
2024
Zhengzhou University
2011-2024
Henan Provincial Center for Disease Control and Prevention
2024
Northwest A&F University
2024
Chinese PLA General Hospital
2022-2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2022-2023
Abstract Metabolic diseases are the most common and rapidly growing health issues worldwide. The massive population-based human genetics is crucial for precise prevention intervention of metabolic disorders. China Analytics Project (ChinaMAP) based on cohort studies across diverse regions ethnic groups with phenotypic data in China. Here, we describe centralized analysis deep whole genome sequencing genetic bases traits 10,588 individuals from ChinaMAP. frequency spectrum variants,...
Background Intestinal dysbiosis is associated with inflammatory bowel disease (IBD). Ulcerative colitis (UC) and Crohn’s (CD), two subtypes of IBD, are characterized by unique microbial signatures, respectively. However, it unclear whether UC or CD has a specific causal relationship gut microbiota. Objective To investigate the potential associations between genera UC, CD, two-sample Mendelian randomization (MR) analyses were conducted. Materials Methods We obtained genome-wide association...
Sleep disturbance is an important factor in the pathophysiology and progression of psychiatric disorders, but whether it a cause, or downstream effect still not clear.
Abstract Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that accompanied by muscle weakness and atrophy, typically resulting in death within 3–5 years from the disease occurrence. Though cause of ALS remains unclear, increasing evidence has suggested inflammation involved pathogenesis ALS. Thus, we performed two-sample Mendelian randomization (MR) analyses to estimate associations circulating levels cytokines growth factors with risk Methods Genetic...
Thyroid cancer is the most common malignant disease of endocrine system. Previous studies indicate a rapid increase in incidence thyroid recent decades, and this has aroused great public concern. The aim study was to analyze trends incidence, mortality clinical-pathological patterns Zhejiang province. Population-based rates were collected from eight registries 2000 2012. age-standardized Segi's world population. A Joinpoint model used examine secular age-adjusted with Regression Program...
Abstract Background Despite their regional economic importance and being increasingly reared globally, the origins evolution of llama alpaca remain poorly understood. Here we report reference genomes for llama, guanaco vicuña (their putative wild progenitors), compare these with published genome, resequence seven individuals all four species to better understand domestication introgression between alpaca. Results Phylogenomic analysis confirms that was domesticated from vicuña. Introgression...
Abstract Background Growing evidence has suggested that gut microbiota is closely related to the risk of irritable bowel syndrome (IBS), but whether there a causal effect remains unknown. We adopted Mendelian randomization (MR) approach evaluate potential relationships between and IBS. Methods Genetic instrumental variables for were identified from genome-wide association study (GWAS) 18,340 participants. Summary statistics IBS drawn GWAS including 53,400 cases 433,201 controls. used...
Objective To explore the associations between metabolic syndrome (MetS) and its individual components risk of rheumatoid arthritis (RA). Methods A total 369,065 individuals were included in present study based on UK Biobank. Multivariable Cox proportional hazards regression models applied to estimate MetS RA. Mediation analysis was performed further assess potential mediating role C-reactive protein (CRP) relationship Results During a median follow-up period 12.04 years, 4901 incident RA...
Metabolic syndrome (MetS) is a cluster of multiple cardiometabolic risk factors that increase the type 2 diabetes and cardiovascular diseases. Identifying novel biomarkers MetS their genetic associations could provide insights into mechanisms diseases.Potential MetS-associated metabolites were screened internally validated by untargeted metabolomics analyses among 693 patients with 705 controls. External validation was conducted using two well-established targeted metabolomic methods 149 253...
This study establishes a Bayesian-structural equation model based on the travel satisfaction survey at Boda Campus of Xinjiang University to construct and optimize slow traffic system campus in cold regions. Moreover, relevant indicators are selected evaluation campus’s Then, strategies proposed according key elements highlighted by system. The results show that subjective emotion perceived time have great influence satisfaction. connectivity density walking cycling network, anti-skid...
Tumor suppressor p53 prevents early death due to cancer development. However, the role of in aging process and longevity has not been well-established. In humans, single nucleotide polymorphism (SNP) with either arginine (R72) or proline (P72) at codon 72 influences activity; P72 allele a weaker activity function tumor suppression. Here, employing mouse model knock-in human TP53 gene carrying SNP, we found that despite increased risk, mice escape development display longer lifespan than R72...
Immune checkpoint inhibitors play a vital role in triple-negative breast cancer (TNBC) immunotherapy. A recent study showed that chemokine-like factor (CKLF)-like MARVEL transmembrane domain containing 6 (CMTM6) has crucial programmed death-ligand 1 (PD-L1) stability. The aim of this was to investigate the relationship between CMTM6 and PD-L1 TNBC association with clinical characteristics.A total 143 patients, including 75 human epidermal growth receptor 2 (HER2)-driven 68 TNBC, were...
DNA methylation is an important epigenetic modification, associated with gene expression. 5-Methylcytosine and 5-hydroxymethylcytosine are two hallmarks that maintain the equilibrium of reprogramming. Disequilibrium in genomic leads to carcinogenesis. The purpose this study was elucidate mechanisms hydroxymethylation carcinogenesis colorectal cancer. Genome-wide patterns six paired tumor tissues corresponding normal were determined using immunoprecipitation sequencing. Transcriptional...
Aberrant expression of forkhead box C1 (FOXC1) promotes tumor metastasis in multiple human malignant tumors. However, the upstream modulating mode and downstream molecular mechanism FOXC1 colorectal cancer (CRC) remain unclear. Herein we describe a systematic analysis prognosis CRC performed on our clinical data public databases, which indicated that upregulation samples was significantly associated with poor prognosis. knockdown inhibited migration invasion, whereas overexpression caused...
Abstract Background Dysregulation of alternative splicing (AS) is a critical signature cancer. However, the regulatory mechanisms cancer-specific AS events, especially impact DNA methylation, are poorly understood. Methods By using The Cancer Genome Atlas (TCGA) SpliceSeq and TCGA data for ten solid tumor types, association analysis was performed to characterize potential link between methylation. Functional pathway enrichment analyses were performed, protein-protein interaction (PPI)...