A5066337255- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Regulation of Appetite and Obesity
- Reproductive System and Pregnancy
- Carcinogens and Genotoxicity Assessment
- interferon and immune responses
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Microtubule and mitosis dynamics
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Cancer Research and Treatments
- CRISPR and Genetic Engineering
- Antioxidant Activity and Oxidative Stress
- Autophagy in Disease and Therapy
- RNA Research and Splicing
- Reproductive Biology and Fertility
- Acute Myeloid Leukemia Research
- Biochemical Analysis and Sensing Techniques
Rutgers, The State University of New Jersey
2016-2025
Rutgers Cancer Institute of New Jersey
2015-2024
Institute of Geographic Sciences and Natural Resources Research
2024
Chinese Academy of Sciences
2024
Johnson University
2020-2023
Dana-Farber Cancer Institute
2007-2021
Harvard University
2008-2021
Boston Children's Hospital
2008-2020
Jilin University
2014-2019
Union Hospital
2019
Cell growth and proliferation requires an intricate coordination between the stimulatory signals arising from nutrients factors inhibitory intracellular extracellular stresses. Alteration of often causes cancer. In mammals, mTOR (mammalian target rapamycin) protein kinase is central node in nutrient factor signaling, p53 plays a critical role sensing genotoxic other The results presented here demonstrate that activation inhibits activity regulates its downstream targets, including autophagy,...
Whereas cell cycle arrest, apoptosis, and senescence are traditionally thought of as the major functions tumor suppressor p53, recent studies revealed two unique for this protein: p53 regulates cellular energy metabolism antioxidant defense mechanisms. Here, we identify glutaminase 2 (GLS2) a previously uncharacterized target gene to mediate these protein. GLS2 encodes mitochondrial catalyzing hydrolysis glutamine glutamate. increases expression under both nonstressed stressed conditions. by...
Leukemia stem cells (LSCs) are capable of limitless self-renewal and responsible for the maintenance leukemia. Because selective eradication LSCs could offer substantial therapeutic benefit, there is interest in identifying signaling pathways that control their development. We studied mouse models acute myelogenous leukemia (AML) induced either by coexpression Hoxa9 Meis1a oncogenes or fusion oncoprotein MLL-AF9. show Wnt/beta-catenin pathway required derived from hematopoietic (HSC) more...
The hypothalamus and other regions within the central nervous system (CNS) link sensing of nutrients to control metabolism feeding behavior. Here, we report that intracerebroventricular (ICV) administration long-chain fatty acid oleic markedly inhibits glucose production food intake. anorectic effect was independent leptin accompanied by a decrease in hypothalamic expression neuropeptide Y. short-chain octanoic failed reproduce metabolic effects acid, ICV coadministration inhibitors...
The insulin-like growth factor 1 (IGF-1)-AKT-mTOR pathways sense the availability of nutrients and mitogens respond by signaling for cell division. p53 pathway senses a variety stress signals which will reduce fidelity division, responds initiating cycle arrest, senescence, or apoptosis. This study explores four p53-regulated gene products, beta1 beta2 subunits AMPK, are shown first time to be regulated protein, TSC2, PTEN, IGF-BP3, each negatively regulates IGF-1-AKT-mTOR after stress....
Regulation of energy metabolism is a novel function p53 in tumor suppression. Parkin (PARK2) , Parkinson disease-associated gene, potential suppressor whose expression frequently diminished tumors. Here was identified as target gene that an important mediator p53's regulating metabolism. The human and mouse genes contain functional responsive elements, increases the transcription both humans mice. contributes to glucose metabolism; deficiency activates glycolysis reduces mitochondrial...
The tumor suppressor gene p53 is frequently mutated in cigarette smoke (CS)-related lung cancer. binding pattern of carcinogenic polycyclic aromatic hydrocarbons (PAHs) found CS coincides with the mutational cancer, and PAHs have thus been considered to be major culprits for However, compared other compounds, such as aldehydes, amount minute. Acrolein (Acr) abundant CS, it can directly adduct DNA. Acr-DNA adducts, similar PAH-DNA induce predominantly G-to-T transversions human cells. These...
Mutations in E3 ubiquitin ligase Parkin have been linked to familial Parkinson's disease. Accumulating evidence suggests that is a tumor suppressor, but the underlying mechanism poorly understood. Here we show an for hypoxia-inducible factor 1α (HIF-1α). interacts with HIF-1α and promotes degradation through ubiquitination, which turn inhibits metastasis of breast cancer cells. downregulation cells metastasis, can be inhibited by targeting RNA interference or small-molecule inhibitor YC-1....
In common forms of obesity, hyperphagia, hyperinsulinemia, and hyperleptinemia coexist. Here, we demonstrate rapid induction insulin leptin resistance by short-term overfeeding. After 3 7 days on the assigned diet regimen, rats were tested for their biological responses to acute elevations in plasma concentrations. Severe metabolic effects both ensued after just During clamp studies, glucose production was decreased ∼70% control 28–53% overfed rats. Similarly, infusion doubled contribution...
Energy balance and insulin action are tightly coregulated. Leptin regulates energy intake expenditure partly by modulation of the melanocortin pathway in hypothalamus. Here we demonstrate potent effects on body distribution adiposity. Conscious rats received week-long infusions either a receptor agonist, α-melanocyte-stimulating hormone (α-MSH), or antagonist, SHU9119, third cerebral ventricle while food was maintained constant each group. α-MSH decreased intra-abdominal fat markedly...
Energy balance and insulin action are tightly coregulated. Leptin regulates energy intake expenditure partly by modulation of the melanocortin pathway in hypothalamus. Here we demonstrate potent effects on body distribution adiposity. Conscious rats received week-long infusions either a receptor agonist, α-melanocyte-stimulating hormone (α-MSH), or antagonist, SHU9119, third cerebral ventricle while food was maintained constant each group. α-MSH decreased intra-abdominal fat markedly...