A5100454353- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
- Glioma Diagnosis and Treatment
- Renal and related cancers
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Mitochondrial Function and Pathology
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Microtubule and mitosis dynamics
- Microbial Natural Products and Biosynthesis
- Breast Cancer Treatment Studies
- Protein Degradation and Inhibitors
- PI3K/AKT/mTOR signaling in cancer
- Nanoparticle-Based Drug Delivery
- Transgenic Plants and Applications
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Cancer Mechanisms and Therapy
- Genetic and Kidney Cyst Diseases
First People’s Hospital of Zunyi
2024-2025
Wuhan Children's Hospital
2017-2025
Jiangsu University
2019-2025
Huazhong University of Science and Technology
2017-2025
University of Missouri
2023-2025
Zunyi Medical University
2024
Third Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2020-2024
Shenzhen University
2022-2024
Xiamen University of Technology
2024
Regulation of energy metabolism is a novel function p53 in tumor suppression. Parkin (PARK2) , Parkinson disease-associated gene, potential suppressor whose expression frequently diminished tumors. Here was identified as target gene that an important mediator p53's regulating metabolism. The human and mouse genes contain functional responsive elements, increases the transcription both humans mice. contributes to glucose metabolism; deficiency activates glycolysis reduces mitochondrial...
Abstract Astrocytes may function as mediators of the impact noradrenaline on neuronal function. Activation glial α1-adrenergic receptors triggers rapid astrocytic Ca 2+ elevation and facilitates synaptic plasticity, while activation β-adrenergic elevates cAMP levels modulates memory consolidation. However, dynamics these processes in behaving mice remain unexplored, do interactions between distinct second messenger pathways. Here we simultaneously monitored demonstrate that messengers are...
Epidemiological studies strongly suggest that chronic psychological stress promotes tumorigenesis. However, its direct link in vivo and the underlying mechanisms cause this remain unclear. This study provides evidence tumorigenesis vivo; restraint, a well-established mouse model to induce stress, greatly ionizing radiation (IR)-induced p53 +/− mice. The tumor suppressor protein plays central role prevention. Loss or attenuation of function contriubutes We found restraint decreases levels...
cAMP is a common second messenger that involved in various physiological processes. To expand the colour palette of available indicators, we developed red indicator named "Pink Flamindo" (Pink Fluorescent indicator). The fluorescence intensity Pink Flamindo increases 4.2-fold presence saturating dose cAMP, with excitation and emission peaks at 567 nm 590 nm, respectively. Live-cell imaging revealed effective for monitoring spatio-temporal dynamics intracellular generated by photoactivated...
Optimal treatment of brain metastases is often hindered by limitations in diagnostic capabilities. To meet this challenge, here we profile DNA methylomes the three most frequent types metastases: melanoma, breast, and lung cancers (n = 96). Using supervised machine learning integration from normal, primary, metastatic tumor specimens 1860), unravel epigenetic signatures specific to each type constructed a three-step methylation-based classifier (BrainMETH) that categorizes according tissue...
To investigate the expression and clinical significance of mitogen‑activated protein kinase (MAPK) epidermal growth factor receptor (EGFR) in triple‑negative breast cancer (TNBC), a total 300 TNBC 120 paired paracancerous tissues were examined. Immunohistochemistry was conducted to determine levels MAPK EGFR, correlation between EGFR evaluated using Cramer's V test. The association expression, various clinicopathological variables (such as lymph node metastasis, stage, recurrence metastasis)...
Abstract Stimuli‐responsive DNA hydrogels are promising candidates for cancer treatment, as they not only possess biocompatible and biodegradable 3D network structures highly efficient carriers therapeutic agents but also capable of undergoing programmable gel‐to‐solution transition upon external stimuli to achieve controlled delivery. Herein, a platform photothermal‐chemo synergistic therapy is established by integrating with Ti 3 C 2 T X ‐based MXene photothermal agent doxorubicin (DOX)...
SOD1 is known as the major cytoplasmic superoxide dismutase and an anticancer target. However, role of in cancer not fully understood. Herein we describe generation inducible Sod1 knockout KRAS-driven NSCLC mouse model. markedly reduces tumor burden vivo blocks growth KRAS mutant cells vitro. Intriguingly, enriched nucleus notably nucleolus cells. The nuclear nucleolar, cytoplasmic, form essential for lung cell proliferation. Moreover, interacts with PeBoW complex controls its assembly...
Primary Coenzyme Q10 (CoQ10) deficiency is an ultra-rare disorder caused by defects in genes involved CoQ10 biosynthesis leading to multidrug-resistant nephrotic syndrome as the hallmark kidney manifestation. Promising early results have been reported anecdotally with oral supplementation. However, long-term efficacy and optimal prescription remain be established. In a global effort, we collected analyzed information from 116 patients who received supplements for primary due biallelic...
Background Lung cancer is the leading cause of cancer-related deaths globally and most common type in China, posing significant health socio-economic challenges. Despite effectiveness psychological interventions for death anxiety, discussions around are often avoided China due to cultural taboos neglect end-of-life care. Purpose This study aimed explore self-designed demands card game (ELDCG) mindfulness-based recovery program (MBCR) programs alleviating depression, stress patients with...
Down syndrome, caused by trisomic chromosome 21, is the leading genetic cause of mental retardation. Recent studies demonstrated that dosage-dependent increases in 21 gene expression occur trisomy 21. However, it unclear whether entire transcriptome disrupted, or there a more restricted increase those genes assigned to Also, statistical significance differentially expressed human syndrome tissues has not been reported.We measured levels transcripts fetal cerebellum and heart using DNA...
The differentiation of antigen-stimulated naive CD4 T cells into helper (Th)1 or Th2 effector can be prevented in vitro by transforming growth factor (TGF)-β and anti–interferon (IFN)-γ. These proliferate synthesize interleukin (IL)-2 but not IFN-γ IL-4, differentiate either Th1 cells. We have now used two-color Elispots to reveal substantial numbers primed producing IL-2 IL-4 during the Th1- Th2-biased immune responses induced soluble proteins with adjuvants. were CD4+CD44high present...
The mouse double minute 4 (MDM4) oncoprotein may inhibit tumorigenesis by regulating the apoptotic mediator p53. Ubiquitin-specific protease 2a (USP2a) is a deubiquitinating enzyme that protects MDM4 against degradation, so USP2–MDM4 interaction be key determinant of malignant potential human cancers. and USP2a, as well MDM4–USP2a complex, were more highly expressed in glioblastoma multiforme tissue samples from patients with good prognosis compared poor prognosis. Analysis prognostic...
Abstract Autophagy and cellular senescence are two critical responses of mammalian cells to stress may have a direct relationship given that they respond the same set stimuli, including oxidative stress, DNA damage, telomere shortening. Mesenchymal stem (MSCs) emerged as reliable cell sources for transplantation currently being tested in numerous clinical trials. However, effects autophagy on MSC corresponding mechanisms not been fully evaluated. Several studies demonstrated level increases...
A serious problem currently facing the field of wound healing is bacterial infection, especially Staphylococcus aureus (S. aureus) infection. Although application antibiotics has achieved good effects, their irregular use resulted in emergence drug-resistant strains. It thus purpose this study to analyze whether naturally extracted phenolic compound, juglone, can inhibit S. The results show that minimum inhibitory concentration (MIC) juglone against was 1000 μg/mL. Juglone inhibited growth...
Rab1A is a small GTPase known for its role in vesicular trafficking. Recent evidence indicates that essential amino acids (aas) sensing and signaling to regulate mTORC1 normal cancer cells. However, Rab1A's vivo function mammals not known. Here, we report the generation of tamoxifen (TAM)-induced whole body knockout (Rab1A
Many studies have found that dietary fiber can protect against colorectal cancer (CRC). Survival in CRC patients is significantly reduced due to metastasis. However, little known regarding the impact of on In this study, we analyzed effects inulin, cellulose, and their mixture metastasis a murine orthotopic transplantation model. BALB/C male mice were divided into normal control (NC) (AIN-93 M diet), MOD INU (10% w/w inulin), CEL cellulose), MIX (5% inulin + 5% cellulose) groups. Dietary...