A5101551236- PI3K/AKT/mTOR signaling in cancer
- Hemoglobin structure and function
- Hedgehog Signaling Pathway Studies
- Cellular transport and secretion
- Cancer Mechanisms and Therapy
- Innovative Microfluidic and Catalytic Techniques Innovation
- Glutathione Transferases and Polymorphisms
- RNA modifications and cancer
- Erythrocyte Function and Pathophysiology
- Extraction and Separation Processes
- Nerve injury and regeneration
- Nanoparticle-Based Drug Delivery
- Endoplasmic Reticulum Stress and Disease
- RNA and protein synthesis mechanisms
- Protein Degradation and Inhibitors
- Hemoglobinopathies and Related Disorders
- Genomics, phytochemicals, and oxidative stress
- Neonatal Health and Biochemistry
- Metal-Catalyzed Oxygenation Mechanisms
- Blood properties and coagulation
- Genetic and Kidney Cyst Diseases
- Signaling Pathways in Disease
- Amyotrophic Lateral Sclerosis Research
- Hippo pathway signaling and YAP/TAZ
- Advanced Biosensing Techniques and Applications
Second Affiliated Hospital of Zhejiang University
2025
Sun Yat-sen University
2015-2025
Sun Yat-sen University Cancer Center
2015-2025
Southeast University
2025
Rutgers, The State University of New Jersey
2015-2024
Rutgers Cancer Institute of New Jersey
2015-2024
Johnson University
2015
Washington University in St. Louis
2002
Hampton University
1999
Illinois Institute of Technology
1988-1998
SOD1 is known as the major cytoplasmic superoxide dismutase and an anticancer target. However, role of in cancer not fully understood. Herein we describe generation inducible Sod1 knockout KRAS-driven NSCLC mouse model. markedly reduces tumor burden vivo blocks growth KRAS mutant cells vitro. Intriguingly, enriched nucleus notably nucleolus cells. The nuclear nucleolar, cytoplasmic, form essential for lung cell proliferation. Moreover, interacts with PeBoW complex controls its assembly...
Peripheral nerve injury (PNI)-induced neuropathic pain (NP) is a severe disease with high prevalence in clinics. Gene reprogramming and tissue remodeling the dorsal root ganglia (DRG) spinal cord (SC) drive development maintenance of (NP). However, our understanding NP-associated spatial molecular processing landscape SC non-synaptic interactions between DRG neurons cells remains limited. We here integrate transcriptomics (ST) single-nucleus RNA-sequencing (snRNA-seq) bulk (bulk RNA-seq) to...
The phosphatidylinositol 3‐kinase/phosphatidylinositol 3,4,5‐trisphosphate 3‐phosphatase/protein kinase B/mammalian target of rapamycin (PI3K‐PTEN‐AKT‐mTOR) pathway is a central controller cell growth and key driver for human cancer. MAF1 an mTOR downstream effector transcriptional repressor ribosomal transfer RNA genes. expression markedly reduced in hepatocellular carcinomas, which correlated with disease progression poor prognosis. Consistently, displays tumor‐suppressor activity toward...
// Bi-Hong Xu 1,* , Xiao-Xing Li Yang 1 Mei-Yin Zhang Hui-Lan Rao 2 Hui-Yun Wang 1,3 and X.F. Steven Zheng State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Center, Guangzhou, China Department Pathology, Yat-Sen 3 Rutgers Institute New Jersey Pharmacology, Robert Wood Johnson Medical School, Rutgers, The Jersey, Brunswick, NJ, USA * These authors have contributed equally to this work Correspondence to: Zheng, email:...
Rab1A is a small GTPase known for its role in vesicular trafficking. Recent evidence indicates that essential amino acids (aas) sensing and signaling to regulate mTORC1 normal cancer cells. However, Rab1A's vivo function mammals not known. Here, we report the generation of tamoxifen (TAM)-induced whole body knockout (Rab1A
Objective EIF4EBP1 acts as a crucial effector in mTOR signaling pathway. Studies have suggested that plays critical role carcinogenesis. However, the clinical significance and biological of hepatocellular carcinoma (HCC) not been elucidated. Therefore, we aimed to investigate HCC. Methods Total 128 cases HCCs were included this study. expression HCC tissues was detected by qRT-PCR, Western blot immunohistochemistry, respectively. Then relationships between features well survival analyzed....
Poly-ADP-ribose polymerase (PARP) inhibitors are vital therapeutic agents that exploit synthetic lethality, particularly effective in tumors with homologous recombination (HR) defects. However, broadening their clinical utility remains a significant challenge. In this study, we conducted high-throughput kinase inhibitor screen to identify potential targets exhibiting synthetical lethality PARP inhibitors. Our results show thousand and one amino acid protein 1 (TAOK1) plays pivotal role the...
Combining molecular classification with clinicopathologic methods improves risk assessment and chooses therapies for endometrial cancer (EC). Detecting mismatch repair (MMR) deficiencies in EC is crucial screening Lynch syndrome identifying immunotherapy candidates. An affordable accessible tool urgently needed to determine MMR status patients. We introduce MMRNet, a deep convolutional neural network designed predict MMR-deficient from whole-slide images stained hematoxylin eosin. MMRNet...
The peripheral sensory nervous system (PNS) has been widely recognized for its role in the collection, processing, and transmission of information, including thermal, mechanical, chemical, proprioceptive stimuli. In recent years, there a growing scholarly interest PNS attributable to multiple physiological pathophysiological non-sensory roles organs it innervates. exerts regulatory functions within innervates through direct interactions with local cells or microbe-nerve-cell that differ from...
Hepatocellular carcinoma (HCC) is one of the most common and deadly human cancers. The 5-year survival rate very low. Unfortunately, there are few efficacious therapeutic options. Until recently, Sorafenib has been only available systemic drug for advanced HCC. However, it limited benefits, new therapies urgently needed. In this study, we investigated anti-HCC activity carfilzomib, a second-generation, irreversible proteasome inhibitor, as single agent in combination with sorafenib.
Spontaneous recovery after CNS injury is often very limited and incomplete, leaving most stroke patients with permanent disability. Maf1 known as a key growth suppressor in proliferating cells. However, its role neuronal cells remains unclear.
Protein kinases are therapeutic targets for human cancer. However, "gatekeeper" mutations in tyrosine cause acquired clinical resistance, limiting long-term treatment benefits. mTOR is a key cancer driver and drug target. Numerous small-molecule kinase inhibitors have been developed, with some already trials. Given our experience targeted therapeutics, resistance thought likely, but not yet documented. Herein, we describe identification of hot spot (L2185) drug-resistant mutations, which...
ABSTRACT Liposomes are microscopic vesicles composed of phospholipid bilayers surrounding discrete aqueous compartment. Eventhough formed spontaneously in water, their conventional preparation methods involve either organic solvents or detergent molecules. Organic may create a serious safety problem during liposome manufacturing especially on large scale and can cause denaturation proteins affect the membrane properties. very promising carriers for protein drugs which have aroused great...