A5103010164- Marine and coastal ecosystems
- Oceanographic and Atmospheric Processes
- Advanced Nanomaterials in Catalysis
- Ocean Acidification Effects and Responses
- Paraquat toxicity studies and treatments
- Hormonal Regulation and Hypertension
- DNA Repair Mechanisms
- Renin-Angiotensin System Studies
- Advanced Cellulose Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Electrospun Nanofibers in Biomedical Applications
- Advanced biosensing and bioanalysis techniques
- PARP inhibition in cancer therapy
- Acute Lymphoblastic Leukemia research
- TiO2 Photocatalysis and Solar Cells
- Peroxisome Proliferator-Activated Receptors
- Integrated Circuits and Semiconductor Failure Analysis
- Cancer-related molecular mechanisms research
- Nanoparticles: synthesis and applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Arctic and Antarctic ice dynamics
- Microbial metabolism and enzyme function
- biodegradable polymer synthesis and properties
- Chronic Kidney Disease and Diabetes
Sun Yat-sen University
2022-2025
Sun Yat-sen University Cancer Center
2022-2025
Jimei University
2022-2023
Honghe University
2018-2022
Second Institute of Oceanography
2017-2022
Ministry of Natural Resources
2022
Xidian University
2020
China XD Group (China)
2020
Qilu University of Technology
2016
First Affiliated Hospital of Wenzhou Medical University
2013-2015
Background Serum C-reactive protein (CRP) is a biomarker of an acute inflammatory response and has been successfully used as prognostic predictor for several malignancies. However, the clinicopathological significance CRP levels in hepatocellular carcinoma (HCC) patients being treated with PD-1 inhibitors remains unclear. Methods were measured total 101 HCC that had from July 2018 to November 2019. The data was retrospectively analyzed identify any clinical implications between responses...
Poly-ADP-ribose polymerase (PARP) inhibitors are vital therapeutic agents that exploit synthetic lethality, particularly effective in tumors with homologous recombination (HR) defects. However, broadening their clinical utility remains a significant challenge. In this study, we conducted high-throughput kinase inhibitor screen to identify potential targets exhibiting synthetical lethality PARP inhibitors. Our results show thousand and one amino acid protein 1 (TAOK1) plays pivotal role the...
Renal fibrosis is a common pathway of virtually all progressive kidney diseases. Osthole (OST, 7-Methoxy-8-(3-methylbut-2-enyl)-2-chromenone), derivative coumarin mainly found in plants the Apiaceae family, has shown inhibitory effects on inflammation, oxidative stress, and tumor progression. The present study investigated whether OST mediates its effect via suppressing fibroblast activation epithelial-mesenchymal transition (EMT) unilateral ureteral obstruction (UUO)-induced renal mice....
ABSTRACT The efficacy of photothermal therapy (PTT) in antitumor applications is often limited by inadequate tumor targeting and low conversion efficiency (PCE) photosensitizers. In this study, we designed a nanoparticle, MPF@IR780, to enhance photosensitizers' PCE. First, MPF@IR780 improves the delivery photosensitizers tissue through enhanced permeability retention (EPR) effect. Furthermore, hydrophobic ferrocene was incorporated into nanoparticle core increase structural compactness,...
Long noncoding RNAs (lncRNAs) play a critical role in gastric cancer (GC) progression and metastasis. However, research comprehensively exploring tissue-derived lncRNAs for predicting peritoneal recurrence patients with GC remains limited. This study aims to investigate the transcriptional landscape of metastasis (PM) develop an integrated lncRNA-based score predict after radical gastrectomy. We analyzed transcriptome profile paired peritoneal, primary tumor, normal tissue specimens from 12...
Multidrug resistance (MDR) is a huge challenge for gastric cancer chemotherapy. Therefore, MDR accurate monitoring of great significance the treatment cancer. GMBP1, an extracellular internalization peptide, can target cells through specific binding to GRP78, which MDR-related protein that overexpressed in cells. Herein, we constructed GMBP1 conjugated Mn3O4 nanoplates (Mn3O4@PEG-GMBP1 NPs) vivo magnetic resonance imaging (MRI). The generated Mn3O4@PEG-GMBP1 NPs had size about 11 nm and...
Optical properties of colored dissolved organic matter (CDOM) were investigated along a latitudinal transect (67°–77° N) in upper water (<80 m depth) the western Arctic Ocean. The absorption coefficient at 280 nm was 0.48–1.25 m−1, with average for oligotrophic basin area (1.04 ± 0.08 m−1) being slightly higher than that productive shelf (0.95 0.16 m−1), implying decoupling effect between CDOM concentration and biological productivity spectral slope S270–350 negatively correlated...
Deep ocean regeneration of dissolved silica (DSi) is an essential part the cycle and driven by a complex series biogeochemical processes. Here we compare distributions DSi other environmental parameters in several western Pacific marginal seas to explore role deep regeneration. Results show that oligotrophic (such as South China Sea), content waters similar adjacent waters. However, productive Bering markedly higher than at same depths. This mainly due sea basin, which fueled high biogenic...
Objective To observe the effects of nuclear factor erythroid 2-related 2 (Nrf2) overexpression on damaged bone marrow mesenchymal stem cells (BMSCs) induced by paraquat (PQ). Methods BMSCs were randomly (random number) divided into six groups: normal BMSCs group, BMSCs-mCherry (Red flurescent protein) BMSCs-Nrf2 BMSCs+ PQ BMSCs-mCherry+ group and BMSCs-Nrf2+ group. The cultured medium. 1.0 mmol/L final concentration PQ. All supernatant collected at 24 h after culture in medium or...