Lina María Serna‐Higuita
A5022647682- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Pediatric Urology and Nephrology Studies
- Complement system in diseases
- Acute Kidney Injury Research
- Cardiac Imaging and Diagnostics
- Muscle and Compartmental Disorders
- Urinary Tract Infections Management
- Cardiovascular Function and Risk Factors
- Pneumocystis jirovecii pneumonia detection and treatment
- Intensive Care Unit Cognitive Disorders
- Chronic Kidney Disease and Diabetes
- Polyomavirus and related diseases
- Pregnancy and Medication Impact
- Neonatal Health and Biochemistry
- Cytomegalovirus and herpesvirus research
- Renal and Vascular Pathologies
- Pharmacological Effects and Toxicity Studies
- Respiratory Support and Mechanisms
- Bipolar Disorder and Treatment
- Coronary Interventions and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Organ Transplantation Techniques and Outcomes
University of Tübingen
2017-2025
Universidad de Antioquia
2012-2024
Universitätsklinikum Tübingen
2023-2024
University of Thessaly
2024
University of Iowa
2024
University of Pittsburgh
2024
University of Washington
2024
Charité - Universitätsmedizin Berlin
2024
University Medical Center Hamburg-Eppendorf
2022
University Children's Hospital Tübingen
2018-2022
In the diagnosis of obstructive coronary artery disease (CAD), computed tomography (CT) is an accurate, noninvasive alternative to invasive angiography (ICA). However, comparative effectiveness CT and ICA in management CAD reduce frequency major adverse cardiovascular events uncertain.We conducted a pragmatic, randomized trial comparing with as initial diagnostic imaging strategies for guiding treatment patients stable chest pain who had intermediate pretest probability were referred at one...
We investigated the value of genetic, histopathologic, and early treatment response information in prognosing long-term renal outcome children with primary steroid-resistant nephrotic syndrome. From PodoNet Registry, we obtained longitudinal clinical for 1354 patients (disease onset at >3 months <20 years age): 612 had documented responsiveness to intensified immunosuppression (IIS), 1155 kidney biopsy results, 212 an established genetic diagnosis. assessed risk factors ESRD using...
BACKGROUND: Rivaroxaban and dabigatran were not superior to aspirin in trials of patients with embolic stroke undetermined source (ESUS). It is unknown whether apixaban ESUS known risk factors for cardioembolism. METHODS: We conducted a multicenter, randomized, open-label, blinded-outcome trial (5 mg twice daily) compared (100 once initiated within 28 days after at least one predictive factor atrial fibrillation or patent foramen ovale. Cardiac monitoring was mandatory, treatment switched...
Primary Coenzyme Q10 (CoQ10) deficiency is an ultra-rare disorder caused by defects in genes involved CoQ10 biosynthesis leading to multidrug-resistant nephrotic syndrome as the hallmark kidney manifestation. Promising early results have been reported anecdotally with oral supplementation. However, long-term efficacy and optimal prescription remain be established. In a global effort, we collected analyzed information from 116 patients who received supplements for primary due biallelic...
Recent advances in digital pathology have enabled accurate and standardised enumeration of tumour-infiltrating lymphocytes (TILs). Here, we aim to evaluate TILs as a percentage electronic TIL score (eTILs) investigate its prognostic predictive relevance cutaneous melanoma.
Background Coronary artery calcium (CAC) has prognostic value for major adverse cardiovascular events (MACE) in asymptomatic individuals, whereas its role symptomatic patients is less clear. Purpose To assess the of CAC scoring MACE participants with stable chest pain initially referred invasive coronary angiography (ICA). Materials and Methods This prespecified subgroup analysis from Diagnostic Imaging Strategies Patients With Stable Chest Pain Intermediate Risk Artery Disease (DISCHARGE)...
Extracorporeal membrane oxygenation is used to stabilize severe cardiocirculatory and/or respiratory failure. However, extracorporeal associated with a coagulopathy characterized by thromboembolic and hemorrhagic complications. This study aimed characterize the pathomechanism of oxygenation-associated identify options optimize its monitoring therapy.Prospective observational clinical trial.ICU university hospital.Patients treated venovenous (n = 10) due acute distress syndrome patients...
In dialyzed patients, preservation of residual renal function is associated with better survival, lower morbidity, and greater quality life. To analyze the evolution diuresis over time, we prospectively monitored urine output in 401 pediatric patients global IPPN registry who commenced peritoneal dialysis (PD) significant function. Associations patient characteristics time-variant covariates daily risk developing oligoanuria (under 100 ml/m(2)/day) were analyzed by mixed linear modeling Cox...
Abstract While children approaching end-stage kidney disease (ESKD) are considered at risk of uremic anorexia and underweight they also exposed to the global obesity epidemic. We sought investigate variation nutritional status in undergoing chronic peritoneal dialysis (CPD) around globe. The distribution course body mass index (BMI) standard deviation score over time was examined prospectively 1001 adolescents from 35 countries starting CPD who were followed International Pediatric PD...
To assess the comparative effectiveness of computed tomography and invasive coronary angiography in women men with stable chest pain suspected to be caused by artery disease. Prospective, multicentre, randomised pragmatic trial. Hospitals at 26 sites 16 European countries. 2002 (56.2%) 1559 (43.8%) (total 3561 patients) disease referred for on basis a pre-test probability obstructive 10-60%. Both were 1:1 (with stratification gender centre) strategy either or as initial diagnostic test (1019...
Abstract Background Acute respiratory distress syndrome (ARDS) results in significant hypoxia, and ARDS is the central pathology of COVID-19. Inhaled prostacyclin has been proposed as a therapy for ARDS, but data regarding its role this are unavailable. Therefore, we investigated whether inhaled would affect oxygenation survival patients suffering from ARDS. Methods We performed prospective randomized controlled single-blind multicenter trial across Germany. The was conducted March 2019 with...
Sepsis is one of the most important complications in preterm infants. For this reason, many such infants receive antibiotics during their hospital stay. However, early antibiotic therapy has also been associated with adverse outcome. It yet largely unclear if time onset influences We here investigated whether timing initiation plays a role association between exposure and short-term outcome.Retrospective analysis data from 1762 very low birthweight born German neonatal intensive care unit...
Ambroxol is a well-known mucolytic expectorant, which has gained much attention in amyotrophic lateral sclerosis, Parkinson's and Gaucher's disease. A specific focus been placed on ambroxol's glucocerebrosidase-stimulating activity, grounds that the point mutation of gba1 gene, codes for this enzyme, risk factor developing However, ambroxol attributed other characteristics, such as potent inhibition sodium channels, modification calcium homeostasis, anti-inflammatory effects modifications...
IntroductionUnlike idiopathic nephrotic syndrome (NS), hereditary podocytopathies are not expected to recur after kidney transplantation. However, some reports of post-transplant recurrence NS in patients carrying variants the NPHS2 gene have been described, notably with p.Arg138Gln variant, which is more prevalent Europe. The objective this study was assess risk transplantation a large cohort biallelic pathogenic variants.MethodsSince January 2010, 61 identified at Necker-Enfants Malades...