Irena Bałasz–Chmielewska
A5016610504- Renal Diseases and Glomerulopathies
- Pediatric Urology and Nephrology Studies
- Coenzyme Q10 studies and effects
- Renal function and acid-base balance
- Childhood Cancer Survivors' Quality of Life
- Dialysis and Renal Disease Management
- Genetic and Kidney Cyst Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Biomedical Research and Pathophysiology
- Adolescent and Pediatric Healthcare
- Renal and related cancers
- Blood Pressure and Hypertension Studies
- Ion Transport and Channel Regulation
- Biochemical Acid Research Studies
- Autoimmune Bullous Skin Diseases
- Celiac Disease Research and Management
- Liver Diseases and Immunity
- Muscle and Compartmental Disorders
- Ovarian cancer diagnosis and treatment
- Genetic Syndromes and Imprinting
- Iron Metabolism and Disorders
- Public health and occupational medicine
- Nuclear Receptors and Signaling
- Parathyroid Disorders and Treatments
- Kidney Stones and Urolithiasis Treatments
Gdańsk Medical University
2009-2025
Medical University of Białystok
2018
Instytut Matki i Dziecka
2011
Primary Coenzyme Q10 (CoQ10) deficiency is an ultra-rare disorder caused by defects in genes involved CoQ10 biosynthesis leading to multidrug-resistant nephrotic syndrome as the hallmark kidney manifestation. Promising early results have been reported anecdotally with oral supplementation. However, long-term efficacy and optimal prescription remain be established. In a global effort, we collected analyzed information from 116 patients who received supplements for primary due biallelic...
Background, Objectives, and Methods Hospitalization mortality rates in pediatric dialysis patients remain unacceptably high. Although studies have associated the presence of comorbidities with an increased risk for death a relatively small number patients, no large-scale study had set out to describe seen or evaluate impact those on outcomes beyond newborn period. In present study, we evaluated prevalence large international cohort chronic peritoneal (CPD) from International Pediatric...
Background: Idiopathic nephrotic syndrome (INS) is the most common cause of in children. A hallmark disease rapid remission proteinuria following a high dose steroids. Recurrent or steroid dependence are common, leading to burden and introduction sparing therapy. Anti-CD20 antibodies have been increasingly used with excellent results complicated INS. Nevertheless, their use can be limited by occurrence infusion-related reactions (IRRs). Methods: This report discusses further treatment...
The aim of this study was to analyze psychosocial aspects chronic kidney disease (CKD) in children treated with automated peritoneal dialysis (APD).The assessed 41 > 2 (range 2.1-18) years age and their parents. Data concerning the illness sociodemographic parameters were collected. Patients completed Paediatric Quality Life Inventory (PedsQL) parents PedsQL-proxy version, General Health Questionnaire (GHQ-12), Berlin Social Support Scales (BSSS), Caregiver's Burden Scale (CBS).Parents rated...
Background. The aim of this nationwide analysis was to assess the incidence and current treatment profile arterial hypertension in children undergoing chronic haemodialysis or peritoneal dialysis attitudes paediatric nephrologists towards choice antihypertensive drugs their patients.
Treatment of steroid resistant nephrotic syndrome is still a challenge for physicians. There are growing number studies exploring genetic background steroid-resistant glomerulopathies. We present the case 4-year-old girl with glomerulopathy due to COQ6 defect no additional systemic symptoms. The disease did not respond second-line therapy calcineurin inhibitor, but it remitted completely after oral treatment 30 mg/kg/d coenzyme Q10 (CoQ10). patient was identified be compound heterozygote two...
To test the association between bilateral nephrectomies in patients with autosomal recessive polycystic kidney disease (ARPKD) and long-term clinical outcome to identify risk factors for severe outcomes, a dataset comprising 504 from international registry study ARegPKD was analyzed characteristics complications of very early (≤ 3 months; VEBNE) (4-15 EBNE) nephrectomies. Patients dialysis (VED, onset ≤ months) without total volumes (TKV) comparable VEBNE infants served as additional control...
IntroductionUnlike idiopathic nephrotic syndrome (NS), hereditary podocytopathies are not expected to recur after kidney transplantation. However, some reports of post-transplant recurrence NS in patients carrying variants the NPHS2 gene have been described, notably with p.Arg138Gln variant, which is more prevalent Europe. The objective this study was assess risk transplantation a large cohort biallelic pathogenic variants.MethodsSince January 2010, 61 identified at Necker-Enfants Malades...
Hereditary nephrotic syndrome is caused by mutations in a number of different genes, the most common being NPHS2. The aim study was to identify spectrum NPHS2 Polish patients with disease. A total 141 children steroid-resistant (SRNS) were enrolled study. Mutational analysis included entire coding sequence and intron boundaries gene. Restriction fragment length polymorphism (RFLP) TaqMan genotyping assay applied detect selected variants 575 population-matched controls. Twenty (14 %) had...
1. Copelovitch L, Warady BA, Furth SL. Insights from the Chronic Kidney Disease in Children (CKiD) study. Clin J Am Soc Nephrol. 2011; 6(8): 2047–2053. CrossRef Google Scholar
Objective.Erythropoiesis-stimulating agents (ESAs) are applied as a standard therapy in children with anaemia chronic kidney disease. The aim of this study was to describe the efficacy and details ESA treatment population dialysed Poland. Material methods. had prospective observational design performed 12 dialysis centres. group comprised 117 mean age at enrolment 165.33 (97.18–196.45) months. Results.Dialysed were treated mostly epoietin beta darbepoietin. dose 99 (68–147) U/kg/week...
Steroid-resistant nephrotic syndrome (SRNS) is a highly heterogenic kidney disorder resulting from genetic abnormalities or immune system dysfunction affecting the establishment and maintenance of glomerular filtration barrier. The most common cause SRNS biallelic pathogenic variants in NPHS2 gene, especially individuals with an infantile childhood onset. type defect implies course disease stage its onset differs across populations. In cohort Polish patients SRNS, unique profile...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Jander A, Makulska I, Latoszyńska J, et al. Clinical research Successes and pitfalls of chronic peritoneal dialysis in infants – a Polish nationwide outcome study. Archives Medical Science. 2010;6(3):414-419. doi:10.5114/aoms.2010.14265. APA Jander, A., Makulska, I., Latoszyńska, J., Boguszewska-Bączkowska, H., Bałasz-Chmielewska, & Zagożdżon, I. (2010). Science, 6(3), 414-419....