A5026501701- Renal Transplantation Outcomes and Treatments
- Telomeres, Telomerase, and Senescence
- Organ Transplantation Techniques and Outcomes
- Blood Pressure and Hypertension Studies
- Renal and Vascular Pathologies
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Renal and related cancers
- Chronic Kidney Disease and Diabetes
- Cardiovascular Health and Disease Prevention
- Birth, Development, and Health
- Renal function and acid-base balance
- Transplantation: Methods and Outcomes
- Cytomegalovirus and herpesvirus research
- Liver Disease and Transplantation
- Electrolyte and hormonal disorders
- Organ Donation and Transplantation
- Genetics, Aging, and Longevity in Model Organisms
- Pregnancy and Medication Impact
- Physical Activity and Health
- Cardiovascular and exercise physiology
- Pediatric Urology and Nephrology Studies
- Complement system in diseases
- Cardiovascular Function and Risk Factors
- Pharmacological Effects and Toxicity Studies
Medizinische Hochschule Hannover
2016-2025
German Center for Infection Research
2022
Zentrum für Kinderheilkunde
2013-2020
Hannover Re (Germany)
2020
Institute for Sports Medicine
2018
University of Salerno
2017
Kinderkrankenhaus auf der Bult
2013-2017
In-Q-Tel
2015
Pediatric Nephrology of Alabama
2000-2014
Heidelberg University
1998-2013
Carotid intima-media thickness (cIMT) and carotid artery distensibility are reliable screening methods for vascular alterations the assessment of cardiovascular risk in adult pediatric cohorts. We sought to establish an international reference data set childhood adolescence period explore impact developmental changes body dimensions blood pressure (BP) on wall elasticity. cIMT, coefficient, incremental modulus elasticity, stiffness index β were assessed 1155 children aged 6 18 years...
Background and objectives Steroid-resistant nephrotic syndrome is a rare kidney disease involving either immune-mediated or genetic alterations of podocyte structure function. The nature, heterogeneity, slow evolution the disorder are major obstacles to systematic genotype-phenotype, intervention, outcome studies, hampering development evidence-based diagnostic therapeutic concepts. To overcome these limitations, PodoNet Consortium has created an international registry for congenital...
We investigated the value of genetic, histopathologic, and early treatment response information in prognosing long-term renal outcome children with primary steroid-resistant nephrotic syndrome. From PodoNet Registry, we obtained longitudinal clinical for 1354 patients (disease onset at >3 months <20 years age): 612 had documented responsiveness to intensified immunosuppression (IIS), 1155 kidney biopsy results, 212 an established genetic diagnosis. assessed risk factors ESRD using...
Senescent renal epithelia promote fibrosis and functional loss after injury, whereas depletion improves regeneration in aged or irradiated kidneys.
Long-term graft survival after kidney transplantation remains unsatisfactory and unpredictable. Interstitial fibrosis tubular atrophy are major contributors to late loss; features of cell senescence, such as increased p16INK4a expression, associate with these tubulointerstitial changes, but it is unknown whether the relationship causal. Here, loss INK4a locus in mice, which allows escape from p16INK4a-dependent significantly reduced interstitial associated improved renal function,...
Background and objectives Cardiovascular disease is the most important comorbidity affecting long-term survival in children with CKD. Design, setting, participants, & measurements The Comorbidity Children CKD Study a multicenter, prospective, observational study ages 6–17 years old initial GFR of 10–60 ml/min per 1.73 m 2 . cardiovascular status monitored annually, subclinical assessed by noninvasive surrogate markers, including left ventricular mass index, carotid intima-media...
Children and adolescents with chronic kidney disease (CKD) are at high risk for cardiovascular morbidity mortality. A systemic arteriopathy cardiomyopathy has been characterized in pediatric dialysis patients by the presence of morphologic functional abnormalities.The Cardiovascular Comorbidity CKD (4C) Study is a multicenter, prospective, observational study aiming to recruit more than 600 children, aged 6 17 years, initial GFR 10 45 ml/min per 1.73 m(2). The prevalence, degree, progression...
Treatment of congenital nephrotic syndrome (CNS) and steroid-resistant (SRNS) is demanding, renal prognosis poor. Numerous causative gene mutations have been identified in SRNS that affect the podocyte. In era high-throughput sequencing techniques, patients with nongenetic frequently escape scientific interest. We here present long-term data German CNS/SRNS Follow-Up Study, focusing on response to cyclosporin A (CsA) versus genetic disease.Cross-sectional longitudinal clinical were collected...
BACKGROUND Aortic pulse wave velocity (PWV), an indicator of arterial stiffness, independently predicts cardiovascular mortality risk in adults. Arterial stiffening advances with age and seems accelerated children certain disease conditions such as chronic kidney or diabetes. The Vicorder, oscillometric device to measure PWV, has been validated children, but reference values a large pediatric cohort, association carotid stiffness influence individual family factors have not determined....
Age is a risk factor for cardiovascular disease, suggesting causal relationship between age-related changes and vascular damage. Endothelial dysfunction an early pathophysiological hallmark in the development of disease. Senescence, cellular equivalent aging, was proposed to be involved endothelial dysfunction, but functional data showing are missing. Endothelium-dependent vasodilation measured aortic rings ex vivo. We investigated aortas from aged C57Bl/6 mice (24–28 months), which p16...
Evidence suggests that autophagy promotes the development of cellular senescence. Because senescence contributes to renal aging and progression from AKI CKD, we investigated potential effect tubular on induction. Compared with kidneys control mice, mice conditional deletion autophagy-related 5 (Atg5) for selective ablation in proximal S3 segments (Atg5 Δ flox/ flox ) presented significantly less senescence, reduced interstitial fibrosis, superior function 30 days after ischemia/reperfusion...
Abstract. The histology and function of the kidney deteriorates with age age-related diseases, but mechanisms involved in renal aging are not known. In vitro studies suggest that telomere shortening is important replicative senescence, accelerated by stresses increase replication. This study explored relationship between length surgical samples from 24 human kidneys, which were either histologically normal (17) or displayed histologic abnormalities (7). Telomere loss was assessed two...
Some features of kidney transplants with dysfunction overlap the lesions aging, such as tubular atrophy and interstitial fibrosis (TA/IF) without major glomerular abnormalities. Somatic cell limitations could contribute to deterioration in aging disease states. Since expression p16(INK4a), a cycle inhibitor associated somatic senescence vitro, is induced aged kidney, we studied whether kidneys TA/IF manifested increased p16(INK4a) expression. We performed immunostaining on transplanted...
There is increasing evidence for a role of somatic cellular senescence in physiological aging but also injury and disease. Cell cycle inhibitor p16 INK4a the key mediator stress aberrant signaling induced senescence. Here we report that elevated blood pressure markedly expression rat kidneys hearts, as well human kidneys. In from deoxycorticosterone acetate-salt–treated rats, induction was found tubular, glomerular, interstitial, vascular cells correlated with typical histopathologic...
Telomeres of most somatic cells progressively shorten, compromising the regenerative capacity human tissues during aging and chronic diseases after acute injury. Whether telomere shortening reduces renal regeneration injury is unknown. Here, ischemia-reperfusion led to greater impairment function increased histopathologic damage in fourth-generation telomerase-deficient mice compared with both wild-type first-generation mice. Critically short telomeres, expression cell-cycle inhibitor p21,...
Chronic antibody-mediated rejection (CAMR) of renal allografts has recently been recognized as a defined nosologic entity. The outcome CAMR is poor; there no established treatment protocol for this condition. We therefore initiated pilot study on with an antihumoral regimen consisting high-dose intravenous immunoglobulin (IVIG) and the chimeric anti-CD20 antibody rituximab.Six pediatric transplant recipients received four weekly doses IVIG (1 g/kg body weight per dose), followed by single...