A5042091424- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal Transplantation Outcomes and Treatments
- Atrial Fibrillation Management and Outcomes
- Organ Transplantation Techniques and Outcomes
- Polyomavirus and related diseases
- Respiratory viral infections research
- Cardiac Arrhythmias and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Mechanical Circulatory Support Devices
- Mycobacterium research and diagnosis
- Microbial infections and disease research
- Mental Health and Patient Involvement
- Cytomegalovirus and herpesvirus research
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Tracheal and airway disorders
- Venous Thromboembolism Diagnosis and Management
- Viral Infections and Immunology Research
- Pulmonary Hypertension Research and Treatments
- Organ and Tissue Transplantation Research
- Cancer-related molecular mechanisms research
- Medical Imaging and Pathology Studies
- Cardiac tumors and thrombi
- Opioid Use Disorder Treatment
University of Alberta
2016-2025
Alberta Health Services
2019-2024
International Society for Heart and Lung Transplantation
2024
IFC Research (United Kingdom)
2024
Texas A&M University
2023
The Metabolomics Innovation Centre
2022
University of Kentucky
2021
University Health Network
2018
Toronto General Hospital
2018
University of Alberta Hospital
2016
Pulmonary veins play an important role in triggering atrial fibrillation (AF). vein isolation (PVI) is effective treatment for patients with paroxysmal AF. However, the late AF recurrence rate long-term follow-up of circumferential PV antral (PVAI) not well documented. We sought to determine time arrhythmia after PVAI, and rates sinus rhythm PVAI.One hundred consecutive a mean age 54 ± 10 years, who underwent PVAI procedure were analyzed. Isolation pulmonary was based on electrophysiological...
The Lung session of the 2017 14th Banff Foundation for Allograft Pathology Conference, Barcelona focused on multiple aspects antibody-mediated rejection (AMR) in lung transplantation. Multidimensional approaches AMR diagnosis, including classification, histological and immunohistochemical analysis, donor- specific antibody (DSA) characterization with their current strengths limitations were reviewed view recent research. group also discussed role tissue gene expression analysis context unmet...
Diagnosing lung transplant rejection currently depends on histologic assessment of transbronchial biopsies (TBB) with limited reproducibility and considerable risk complications. Mucosal are safer but not histologically interpretable. Microarray-based diagnostic systems for TBBs other transplants suggest such could assess mucosal as well. We studied 243 from the third bronchial bifurcation (3BMBs) collected seven centers classified them using unsupervised machine learning algorithms. Using...
Baseline lung allograft dysfunction (BLAD) after transplant is associated with an increased risk of dying, but the association health-related quality life (HRQL) and exercise capacity not known. We hypothesized that BLAD would be reduced HRQL 6-min walk distance (6MWD) at 1 y post-lung transplant. analyzed patients who underwent transplants in our program from 2004 to 2018 completed 1-y 36-item Short Form (SF-36) questionnaire 6MWD testing. secondarily Beck Depression Inventory Borg dyspnea...
ABSTRACT Background Substance use is common among lung transplant donors, but concerns persist about graft damage. Stimulant drugs such as cocaine and methamphetamine can induce pulmonary arterial hypertension, while smoked products cannabis crack produce airway parenchymal diseases. We sought to characterize donor substance at our center evaluate the associations with recipient survival well chronic allograft dysfunction (CLAD), severe primary (PGD3), baseline (BLAD). Methods studied...
Non-tuberculous mycobacteria (NTM) are environmental organisms that colonize or infect lung transplant recipients. Because of differences in populations studied and geographical diversity species, risk factors for infection its impact on patient outcomes post conflicting the literature.We reviewed charts 375 recipients at University Alberta Hospital (Edmonton, Canada) between 2005 2014 to assess NTM epidemiology factors. positivity was determined from a laboratory database. The graft...
Care coordination models have developed in response to the recognition that Australia’s health and welfare service system can be difficult access, navigate is often inefficient caring for people with severe persistent mental illness (SPMI) complex care support needs. This paper explores how Australian Government’s establishment of Partners Recovery (PIR) initiative provides an opportunity development more effective efficient coordinated identified SPMI their families carers. In...
Fluoroscopy remains a cornerstone imaging technique in contemporary electrophysiology practice. We evaluated the impact of collimation to 'minimal required field size' on clinically significant parameters radiation exposure.Radiation dose measured by area product (DAP) and rate DAP per minute fluoroscopy were determined for all 571 procedures performed single laboratory from January 2010 December 2010. Data 205 one interventional electrophysiologist, who instituted practice routinely...
Hyperammonemia syndrome (HS) is a rare complication with high mortality described after lung transplantation. Its pathophysiology still unclear, but previous studies, including murine models, have linked the identification of Mycoplasmataceae in airway specimens HS occurrence. This study explores association between polymerase chain reaction (PCR) positivity, ammonia levels, HS, and post-lung transplant. Adults who underwent transplantation July 2017 August 2019 had prospective surveillance...
Abstract Lung transplantation remains the best treatment option for end-stage lung disease; however, is limited by a shortage of donor grafts. Ex situ perfusion, also known as ex vivo has been shown to allow safe evaluation and reconditioning extended criteria lungs, increasing utilization. Negative pressure ventilation perfusion shown, preclinically, result in less ventilator-induced injury than positive ventilation. Here we demonstrate that, single-arm interventional study...
Transplanted lungs suffer worse outcomes than other organ transplants with many developing chronic lung allograft dysfunction (CLAD), diagnosed by physiologic changes. Histology of transbronchial biopsies (TBB) yields little insight, and the molecular basis CLAD is not defined. We hypothesized that gene expression in TBBs would reveal nature distinguish from changes due simply to time posttransplant. Whole-genome mRNA profiling was performed microarrays 498 prospectively collected INTERLUNG...
In lung transplantation, antibody-mediated rejection (AMR) diagnosed by ISHLT criteria is uncommon compared to other organs, and previous studies failed find molecular AMR (ABMR) in biopsies. However, understanding of ABMR has changed with the recognition that kidney transplants often DSA-negative associated NK cell transcripts. We therefore searched for a similar ABMR-like state transbronchial biopsies (TBBs) using gene expression microarray results from INTERLUNG study (#NCT02812290)....
Abstract Canadian lung transplant centers currently use a subjective and dichotomous “Status” ranking to prioritize waitlisted patients for transplantation. The allocation score (LAS) is an objective composite derived from clinical parameters associated with both waitlist post‐transplant survival. We performed retrospective cohort study determine whether judgment (Status) or LAS better predicted mortality. All adult listed transplantation between 2007 2012 at three programs were included....