A5100603033- Nuclear physics research studies
- Telomeres, Telomerase, and Senescence
- Advanced biosensing and bioanalysis techniques
- T-cell and B-cell Immunology
- Biosensors and Analytical Detection
- Quantum Chromodynamics and Particle Interactions
- MicroRNA in disease regulation
- Hemoglobinopathies and Related Disorders
- Circular RNAs in diseases
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- Neutrino Physics Research
- Cancer, Hypoxia, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Growth Hormone and Insulin-like Growth Factors
- Iron Metabolism and Disorders
- Circadian rhythm and melatonin
- Immune Cell Function and Interaction
- Radioactive Decay and Measurement Techniques
- CRISPR and Genetic Engineering
- Mitochondrial Function and Pathology
- Tuberculosis Research and Epidemiology
- Microbial Inactivation Methods
- Astronomical and nuclear sciences
Institute of Hydroecology
2025
Affiliated Hospital of Youjiang Medical University for Nationalities
2015-2024
Baise University
2024
Jilin Agricultural University
2009-2024
Second Xiangya Hospital of Central South University
2021-2024
Central South University
2021-2024
Shanxi Medical University
2007-2024
Wuhan University
2023-2024
Guangxi Center for Disease Prevention and Control
2024
Southwest Hospital
2024
Summary Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix‐degrading enzymes reactive oxygen species (ROS). Thus, it has been proposed that senescent can damage their local environment, a stimulatory effect on tumour cell invasiveness documented. However, was unknown what effect, if any, have normal, proliferation‐competent counterparts. We show here induce DNA response, characteristic for senescence, in neighbouring via gap...
The impact of cellular senescence onto aging organisms is not fully clear, at least because the scarcity reliable data on mere frequency senescent cells in tissues. Activation a DNA damage response including formation foci containing activated H2A.X (gamma-H2A.X) either uncapped telomeres or persistent strand breaks major trigger cell senescence. Therefore, gamma-H2A.X immunohistochemistry (IHC) was established by us as quantitative indicator fibroblasts vitro and hepatocytes vivo age...
Summary In senescent cells, a DNA damage response drives not only irreversible loss of replicative capacity but also production and secretion reactive oxygen species (ROS) bioactive peptides including pro‐inflammatory cytokines. This makes cells potential cause tissue functional decline in aging. To our knowledge, we show here for the first time evidence suggesting that induces senescence‐like state mature postmitotic neurons vivo . About 40–80% Purkinje 20–40% cortical, hippocampal...
Telomeres of most somatic cells progressively shorten, compromising the regenerative capacity human tissues during aging and chronic diseases after acute injury. Whether telomere shortening reduces renal regeneration injury is unknown. Here, ischemia-reperfusion led to greater impairment function increased histopathologic damage in fourth-generation telomerase-deficient mice compared with both wild-type first-generation mice. Critically short telomeres, expression cell-cycle inhibitor p21,...
Aging | doi:10.18632/aging.100196. Chunfang Wang, Mandy Maddick, Satomi Miwa, Diana Jurk, Rafal Czapiewski, Gabriele Saretzki, Sabine A.S. Langie, Roger W.L. Godschalk, Kerry Cameron, Thomas von Zglinicki
Background Carbapenem-resistant Acinetobacter baumannii (CRAB) poses a severe nosocomial threat, prompting need for efficient detection methods. Traditional approaches, such as bacterial culture and PCR, are time-consuming cumbersome. The CRISPR-based gene editing system offered potential approach point-of-care testing of CRAB. Methods We integrated recombinase polymerase amplification (RPA) CRISPR-Cas12a to swiftly diagnose CRAB-associated genes, OXA-51 OXA-23 . This multiplex...
Microscopic examination of thick and thin blood smears stained with Giemsa dye is considered the primary diagnostic tool for confirmation management suspected clinical malaria. However, detecting gametocytes relatively insensitive, particularly in asymptomatic individuals low-density Plasmodium infections. To complement existing methods, a rapid ultrasensitive point-of-care testing (POCT) platform malaria detection urgently needed necessary. A based on recombinase polymerase amplification...
Abstract Background Foxtail millet ( Setaria italica (L.) P. Beauv.), one of the most ancient domesticated crops, is becoming a model system for studying biofuel crops and comparative genomics in grasses. However, knowledge on level genetic diversity linkage disequilibrium (LD) very limited this crop its wild ancestor, green foxtail viridis Beauv.). Such information would help us to understand domestication process cultivated species will allow further research these species, including...
Epidemiological studies have demonstrated that type 2 diabetes mellitus (T2DM) and hyperinsulinemia are associated closely with endometrial carcinoma risk, although the molecular mechanism remains unclear. Insulin receptor isoformA expression is upregulated in many cancer cells tissues, which suggests IR-A-mediated signaling pathways may important implications for pathogenesis. We measured of insulin isoforms (IR-A IR–B normal endometrium tissues cell lines. found total (IR) IR-A mRNA levels...
Background The impairment of the inner blood–retinal barrier (iBRB) increases pathological development diabetic retinopathy (DR), a severe complication in patients. Identifying approaches to preserving iBRB integrity and function is significant challenge DR. C1q/tumor necrosis factor-related protein-3 (CTRP3) newly discovered adipokine vital biomarker, predicting DR severity. We sought determine whether how CTRP3 affects non-proliferative (NPDR). Methods To clarify pathophysiologic progress...
Green foxtail (Setaria viridis) is a new model plant for the genomic investigation of C4 photosynthesis biology. As ancestor millet italica), an ancient cereal great importance in arid regions world, green crucial study domestication and evolution this crop. In present study, 288 accessions, which were collected from all geographical China, analysed using 77 simple sequence repeats (SSRs) that cover whole genome. A high degree molecular diversity was detected these with average 33.5 alleles...
Accumulating evidence indicates that Clara cell protein-16 (CC16) has anti-inflammatory functions, although the involved molecular pathways have not been completely elucidated. Here, we evaluated effect of recombinant rat CC16 (rCC16) on expression tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and IL-8 in lipopolysaccharide (LPS)-stimulated mouse macrophages (RAW264.7 cells) explored underlying mechanisms. It was found rCC16 inhibited LPS-induced TNF-α, IL-6, at both messenger...