A5101422139- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Circular RNAs in diseases
- Signaling Pathways in Disease
- Cancer-related molecular mechanisms research
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Neuroscience and Neuropharmacology Research
- RNA Research and Splicing
- Receptor Mechanisms and Signaling
- Epilepsy research and treatment
- Genetics and Neurodevelopmental Disorders
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Amino Acid Enzymes and Metabolism
- Sirtuins and Resveratrol in Medicine
- HER2/EGFR in Cancer Research
- Advanced Glycation End Products research
- Autophagy in Disease and Therapy
- RNA regulation and disease
- Biopolymer Synthesis and Applications
- RNA Interference and Gene Delivery
Nanchang University
2025
First Affiliated Hospital of Jiangxi Medical College
2025
First Affiliated Hospital of Zhengzhou University
2016-2024
Guangdong Medical College
2014-2023
Affiliated Hospital of Guangdong Medical College Hospital
2019-2022
Shantou University Medical College
2018-2022
Shantou University
2018-2022
Jiangnan University
2005-2016
Indus University
2005
Alzheimer's disease (AD) is the most common cause of dementia and cannot be cured. The etiology pathogenesis AD still not fully understood, genetics considered to one important factors for onset, identified susceptible genes could provide clues mechanism also potential targets. MicroRNA-146a-5p (miR-146a) well known in regulation inflammatory response, functional SNP miR-146a was associated with risk. In this study, using a noninvasive nasal administration, we discovered that agomir (M146AG)...
Alzheimer's disease (AD) is the most prevalent neurodegenerative and currently has no effective treatment. Mainstream research on mechanisms therapeutic targets of AD focused two important hallmarks, Aβ Tau, but results from clinical studies are not encouraging. Abnormal microglial polarization a clear typical pathological feature in progression AD. Microglia can be neuroprotective by degrading removing Tau. However, under conditions, microglia transform into pro-inflammatory phenotype that...
Advances in synthetic biology have enabled the development of tumor-targeted live bacterial therapeutics. In a recent study published Nature , Redenti et al. engineered Escherichia coli Nissle 1917(EcNcΔlon/ΔompT/LLO+ nAg), which exploits advantages living medicines to deliver arrays tumor-specific neoantigenic epitope optimal environments, thereby providing novel strategy for developing effective and durable cancer immunotherapies.
MicroRNA-146a (miR-146a) acts as a pivotal regulatory molecule in immune response and various diseases, such carcinoma autoimmune diseases. Growing evidences have demonstrated the association of miR-146a gene single-nucleotide polymorphisms (SNPs) with risk several but no genetic relevance studies to sepsis been reported by now. Our study has analyzed two functional SNPs rs2910164 G/C rs57095329 A/G Chinese Han population (226 cases; 206 healthy controls). results indicated higher prevalence...
Unveiling the key mechanism of temporal lobe epilepsy (TLE) for development novel treatments is increasing interest, and anti-inflammatory miR-146a now considered a promising molecular target TLE. In current study, C57BL/6 TLE mouse model was established using lithium-pilocarpine protocol. The seizure degree evaluated according to Racine scale, level 5 threshold generalized convulsions. Animals were sacrificed analyze hippocampus at three time points (2 h 4 8 weeks after pilocarpine...
miR146a is well known for its regulatory role in the immune response and inflammation. Recent studies have demonstrated links between Alzheimer disease (AD) suggested that may be involved neuroinflammation metabolism of amyloid-β (Aβ), which are critical events AD pathology. Although genetic focused on association gene susceptibility to several diseases, no study variability with has been conducted. In this report, we performed a case-control analyze genotype allele distributions miR146a,...
Although genetic variants of the A disintegrin and metalloproteinase 10 (ADAM10) gene have been shown to be associated with susceptibility several inflammatory-related diseases, date little is known about clinical relationship in development sepsis.Two promoter ADAM10 were selected analyze potential association risk sepsis. total 440 sepsis patients 450 matched healthy individuals two independent Chinese Han population enrolled. Pyrosequencing polymerase chain reaction-length polymorphism...
Previous studies have indicated that the monocyte chemo-attractant protein 1 (MCP-1), also referred to as C-C motif chemokine ligand 2 (CCL2), plays a significant role in pathogenesis of sepsis, and this study investigated clinical relevance two MCP-1 gene polymorphisms on sepsis onset progression. The Multiplex SNaPshot genotyping method was used detect Chinese Han population (403 patients 400 controls). mRNA expression levels were measured using real-time quantitative PCR, enzyme-linked...
Abstract Growing evidence indicated that single nucleotide polymorphisms (SNPs) in the apolipoprotein E ( APOE ) gene are related to increase risk of many inflammatory-related diseases. However, few genetic studies have associated polymorphism with sepsis. This study was investigate clinical relevance onset and progression A multicenter case–control association a large sample size (601 septic patients 699 healthy individuals) conducted. Clinical data showed APOEε4 allele overrepresented...
Radiation-induced brain injury is a major adverse event in head and neck tumor treatment, influencing the quality of life for more than 50% patients who undergo radiation therapy experience long-term survival. However, no effective treatments are available these patients, preventative drugs drug-delivery methods must be developed. Based on our results, miR-122-5p was upregulated mouse radiation-induced (RBI) model with nasopharyngeal carcinoma (NPC) received therapy. Intranasal...
Background: A disintegrin and metalloproteinase 17 (ADAM17) has been confirmed to play a significant role in the pathogenesis of sepsis. However, little is known about clinical relevance ADAM17 polymorphisms sepsis onset development. Methods: This study analyzed associations five promoter (rs55790676, rs12692386, rs11684747, rs1524668 rs11689958) with (370 cases 400 controls). Genotyping was performed using pyrosequencing polymerase chain reaction-length polymorphism method. The expression...
The RNA binding protein TRA2A, a member of the transformer 2 homolog family, plays crucial role in alternative splicing pre-mRNA.However, it remains unclear whether TRA2A is involved non-coding regulation and, if so, what are functional consequences.By analyzing expression profiling data, we found that highly expressed esophageal cancer and associated with disease-free survival overall time.Subsequent gain-and loss-of-function studies demonstrated promotes proliferation migration squamous...
Circular RNAs (circRNAs) are highly expressed in the central nervous system and have been reported to be associated with neuropsychiatric diseases, but their potential role major depressive disorder (MDD) remains unclear. Here, we demonstrated that there was a of circRNAs blood MDD patients. It has preliminarily proved hsa_circ_0002473, hsa_circ_0079651, hsa_circ_0137187, hsa_circ_0006010, hsa_circ_0113010 were patients can used as diagnostic markers for MDD. Bioinformatics analysis revealed...
Alzheimer's disease, among the most common neurodegenerative disorders, is characterized by progressive cognitive impairment. At present, disease main risk remains genetic risks, but major environmental factors are increasingly shown to impact development and progression. Microglia, important brain immune cells, play a central role in pathogenesis considered lifestyle “sensors.” Factors like pollution modern lifestyles (e.g., chronic stress, poor dietary habits, sleep, circadian rhythm...
Abstract Previous studies demonstrated significant roles of autophagy in the pathogenesis sepsis, but few focused on effect autophagy-related SNPs sepsis susceptibility. In this present study, five polymorphisms ATG5/ATG16L1 were investigated for possible risk a Chinese Han population. Our results showed that ATG5 expression levels decreased with severity and rs506027 T > C rs510432 G A associated progression mortality. Moreover, TT GG carriers also exhibited increased ATG5. Functional...
Background/Aims: Increasing evidence suggests the important role of sirtuin 2 (SIRT2) in pathology Parkinson’s disease (PD). However, association between potential functional polymorphisms SIRT2 gene and PD still needs to be identified. Exploring molecular mechanism underlying this could also provide novel insights into pathogenesis disorder. Methods: Bioinformatics analysis screening were first performed find microRNAs (miRNAs) that target gene, biology experiments carried out further...