A5024811171- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Photoacoustic and Ultrasonic Imaging
- Extracellular vesicles in disease
- Nonmelanoma Skin Cancer Studies
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- bioluminescence and chemiluminescence research
- Circular RNAs in diseases
- Skin Protection and Aging
- Cancer Genomics and Diagnostics
- Retinoids in leukemia and cellular processes
- Muscle Physiology and Disorders
- RNA modifications and cancer
- Gold and Silver Nanoparticles Synthesis and Applications
- Immunotherapy and Immune Responses
- Quantum Dots Synthesis And Properties
- Nanoparticle-Based Drug Delivery
- Mitochondrial Function and Pathology
- Perovskite Materials and Applications
- Ultrasound and Hyperthermia Applications
University of Chinese Academy of Sciences
2016-2025
Henan Provincial People's Hospital
2014-2024
Hunan Normal University
2022-2024
Oslo University Hospital
2015-2024
Fudan University
2010-2024
Shanghai Institute of Nutrition and Health
2021-2024
Zhengzhou University
2015-2024
First Affiliated Hospital of Zhengzhou University
2020-2024
Southwest University
2024
Henan University
2024
Exosomes are extracellular vesicles produced by all cells with a remarkable ability to efficiently transfer genetic material, including exogenously loaded siRNA, cancer cells. Here, we report on bioreactor-based, large-scale production of clinical-grade exosomes employing good manufacturing practice (GMP) standards. A standard operating procedure was established generate engineered the target oncogenic Kras (iExosomes). The GMP iExosomes were tested in multiple vitro and vivo studies confirm...
The high non-radiative energy loss is a bottleneck issue that impedes the improvement of organic solar cells. formation triplet exciton thought to be main source large loss. Decreasing rate back charge transfer considered as an effective approach alleviate relaxation charge-transfer state and generation. Herein, we develops efficient ternary system based on D18:N3-BO:F-BTA3 by regulating disorder blend. With addition F-BTA3, well-defined morphology with more condensed molecular packing...
It is hard to imagine that a narrow, one-way, coherent, moving, amplified beam of light fired by excited atoms powerful enough slice through steel. In 1917, Albert Einstein speculated under certain conditions could absorb and be stimulated shed their borrowed energy. Charles Townes coined the term laser (light amplification emission radiation) in 1951. Theodore Maiman investigated glare flash lamp rod synthetic ruby, creating first human-made 1960. The involves exciting passing them medium...
Abstract Several parameters of the following dyes, all relevant as sensitizers for photochemotherapy cancer, have been studied: Photofrin II (PII), hematoporphyrin (HP)‐di‐hexyl‐ether, HP‐di‐ethyl‐ether, tetra (3‐hydroxyphenyl) porphyrin, (3THPP), tetraphenyl porphine tetrasulphonate (TPPS 4 ) aluminium phthalocyanine tetrasulfonate (A1PCTS), (A1PC), chlorin e, (Chi e 6 and merocyanine 540 (MC 540). The features these dyes were (1) Tumor uptake in C3H mouse mammary carcinomas. (2) Skin/tumor...
Abstract— Microscopic fluorescence photometry incorporating a light‐sensitive thermo‐electrically cooled charge‐coupled device (CCD) camera was employed to investigate the distribution of 5‐aminolevulinic acid (ALA)‐induced porphyrins in 22 patients with total number 52 noduloul‐cerative basal cell carcinomas (BCC) after topical ALA application or without dimethylsulfoxide (DMSO)/ethylenediaminetetraacetic (EDTA) intravenous administration ALA. Both localization patterns and amounts...
Abstract Currently the greatest challenge in oncology is lack of homogeneity lesions where different cell components respond differently to treatment. There growing consensus that monotherapies are insufficient eradicate disease and there an unmet need for more potent combinatorial treatments. We have previously shown hypericin photodynamic therapy (HYP-PDT) triggers electron transport chain (ETC) inhibition mitochondria. also tamoxifen (TAM) enhances cytotoxicity cells with high...
Minimizing energy loss is crucial for breaking through the efficiency bottleneck of organic solar cells (OSCs). The main mechanism can be attributed to non-radiative recombination (ΔEnr) that occurs due exciton-vibration coupling. To tackle this challenge, tuning intramolecular noncovalent interactions strategically utilized tailor novel fused ring electron acceptors (FREAs). Upon comprehensive analysis both theoretical and experimental results, approach effectively enhance molecular...
Abstract By means of a chemical extraction procedure and confocal laser scanning microscopy, we investigated the kinetic patterns uptake biolocalization 5‐aminolevulinic acid (ALA)‐induced porphyrins in s.c. transplanted tumors, adjacent normal skin muscle, liver mice bearing mammary carcinoma, after i.p. injection 250 mg/kg ALA or topical application (20% an oil‐in‐water emulsion). Furthermore, evaluated tumor responses either 5‐ALA followed by irradiation (632 nm, 150 mW/cm 2 , 25 min)...