A5053003109- Hemoglobinopathies and Related Disorders
- Heart Failure Treatment and Management
- Pulmonary Hypertension Research and Treatments
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Renin-Angiotensin System Studies
- Traditional Chinese Medicine Studies
- Biosensors and Analytical Detection
- COVID-19 and healthcare impacts
- Advanced biosensing and bioanalysis techniques
- Autoimmune Bullous Skin Diseases
- Cardiovascular Function and Risk Factors
- Toxin Mechanisms and Immunotoxins
- Renal Diseases and Glomerulopathies
- Long-Term Effects of COVID-19
- Steroid Chemistry and Biochemistry
- Cardiac Imaging and Diagnostics
- SARS-CoV-2 and COVID-19 Research
- Porphyrin Metabolism and Disorders
- GDF15 and Related Biomarkers
- COVID-19 and Mental Health
- Pharmacological Effects of Natural Compounds
- Chronic Kidney Disease and Diabetes
- Nosocomial Infections in ICU
- Enzyme Production and Characterization
Shanghai East Hospital
2025
Nanjing University of Aeronautics and Astronautics
2025
First Affiliated Hospital of Guangzhou Medical University
2023-2024
State Key Laboratory of Respiratory Disease
2023-2024
Guangzhou Medical University
2023-2024
National Clinical Research
2024
University of California, San Diego
2024
Sichuan Normal University
2019-2021
Sun Yat-sen University
2014-2020
Zhongshan Hospital
2011-2020
Talaromycosis is a rare fungal infection characterized by non-specific clinical features, often resulting in misdiagnosis. This study aimed to analyze four classic cases of Talaromyces marneffei diagnosed using metagenomic next-generation sequencing (mNGS) improve understanding its diagnosis and treatment. retrospectively analyzed T. identified through mNGS at Peking Union Medical College Hospital. Four confirmed talaromycosis were selected based on diagnoses, supplemented review relevant...
Abstract Introduction Procalcitonin (PCT) is a biomarker for the clinical diagnosis of bacterial infection that more specific and earlier than fever, changes in white blood cell count, cultures. Congestive heart failure an important cause endotoxin resorption from intestine, which significantly increases PCT expression noninfected patients with failure. The diagnostic performance cut-off value complicated by congestive needs to be confirmed. Methods A total 4,698 cases different cities...
Abstract It was reported that histopathologic lesions are risk factors for the progression of IgA Nephropathy (IgAN). The aim this study to investigate relationships between mesangial deposition C1q and renal outcomes in IgAN. 1071 patients with primary IgAN diagnosed by biopsy were enrolled multiple centers form January 2013 2017. Patients divided into two groups: C1q-positive C1q-negative. Using a 1: 4 propensity score matching (PSM) method identifying age, gender, treatment modality...
To differentiate the value of hemoglobin A1c (HbA1c), glycated albumin (GA) and glycosylated serum protein (GSP) in monitoring blood glucose patients with aplastic anemia.42 anemia (AA) 30 AA Type 2 diabetes mellitus (T2DM) were enrolled study, comparison 114 healthy subjects 88 T2DM. HbA1c, GA, GSP, fasting plasma (FPG), (Hb) (ALB) measured, group correlation analysis carried out.Compared non-diabetes while ALB <30 g/l or 30-40 g/l, HbA1c GSP values AA, T2DM AA+T2DM significantly higher GA...
Chronic kidney disease (CKD) is a significant risk factor for pulmonary hypertension (PH), complication that adversely affects patient prognosis. However, the mechanisms underlying this association remain poorly understood. A major obstacle to progress in field lack of reliable animal model replicating CKD-PH. This study aimed establish stable rat We employed combined approach, inducing CKD through 5/6 nephrectomy and concurrently exposing rats high-salt diet. The model's hemodynamics were...
: Hemoglobin (Hb) A
Background: The outbreak of coronavirus disease 2019 (COVID-19) has attracted global attention. During the lockdown period COVID-19, follow-up many patients with chronic had been interrupted, which brought severe challenges to better management their disease. This study aimed at exploring change illness, daily life, and psychological responses during COVID-19 pandemic among kidney (CKD) patients. Methods: A total 612 were enrolled in this study; 282 categorized into CKD stage 1–2 group 330...
ObjectiveTo determine whether BNP or NT-proBNP levels more strongly indicate predict cardiac diseases in patients with chronic heart failure, cerebral infarction, hemorrhage, and acute infarction complicated failure.
The objectives of present study were to evaluate the effect casein kinase 1 (CK1) inhibition D4476 on in vitro maturation (IVM) and developmental competence bovine oocytes. cumulus oocyte complexes (COCs) cultured medium with (0, 2, 5, 10, 20 μM) for 24 hr. After IVM fertilization, through expansion average scores cells (CCs), efficiency, cleavage rate blastocyst zygote, we found 5 μM could increase development potential COCs treated D4476, results quantitative real-time PCR analysis, Lichen...
Abstract Right heart failure is the leading cause of death in pulmonary hypertension (PH), and echocardiography a commonly used tool for evaluating risk hierarchy PH. However, few studies have explored dynamic changes structural functional right during process Previous found that circulation coupling ventricular adaptation depends on degree pressure overload other factors. In this study, we performed time-dependent evaluation using transthoracic SU5416 plus hypoxia (SuHx)-induced PH rat...
Objective: To apply biological variation and six Sigma models to evaluate analysis performance of 6 HbA1c analyzers design the new quality control strategy. Method: We collected data imprecision inaccuracy from routine internal (June 2017-December 2017) proficiency test NGSP, respectively. The coefficient variance (CV)% bias% were plotted in sigma models. strategy was designed by value OPSpecs. improvement guided QGI. Results: analytical our laboratory good model, However, 50% (3/6) 67%...
Abstract Objective The interference of the hemoglobin variant (Hb J-Bangkok) was evaluated on 4 different glycated assays and compared with a reference immuno assay. Methods An overall test coincidence 2 least-squares linear regression lines performed to determine whether presence Hb J-Bangkok caused statistically significant difference in HbA1c results Statistical analysis estimated average glucose calculated from values fasting plasma group using detection systems. Deming used determinate...
Background To explore the effects of HbJ Bangkok, HbE, HbG Taipei, and α‐thalassemia HbH on results HbA1c assessment using ion‐exchange high‐performance liquid chromatography ( IE ‐ HPLC ). Methods We enrolled five patients in which assay were inconsistent with average levels FBG . performed hemoglobin capillary (Hb) electrophoresis whole‐blood samples. also sequenced genes encoding Hb dideoxy‐mediated chain termination analyzed borate affinity BA ) turbidimetric inhibition immunoassay TINIA...
NSC67657 is a new steroid drug that induces monocytic differentiation of acute myeloid leukemia cells. Here, we demonstrate has opposing effects on expression downstream targets inhibitor β-catenin and TCF (ICAT) Wnt signaling in HL60 ICAT binds to β-catenin, this interaction further increased NSC67657-differentiated overexpression decreases increases sensitivity cells NSC67657, while silencing delays the NSC67657-induced cell differentiation. In addition, pharmacological inhibition...
Abstract Background Pulmonary hypertension (PH) is a common complication in patients with chronic kidney disease (CKD), affecting prognosis. However, the pathogenesis not clear, and lack of stable animal model significant factor. Methods In this study, rat pulmonary (CKD-PH) was developed through 5/6 nephrectomy combined high-salt diet. The model’s hemodynamics pathological changes multiple organs were dynamically assessed. Lung tissues serum collected from rats to measure expression ACE2,...
Abstract Background： Pulmonary hypertension (PH) is a common complication in patients with chronic kidney disease (CKD), affecting prognosis. However, the pathogenesis not clear, and lack of stable animal model significant factor. Methods： In this study, rat pulmonary (CKD-PH) was developed through 5/6 nephrectomy combined high-salt diet. The model's hemodynamics pathological changes multiple organs were dynamically assessed. Lung tissues serum collected from rats to measure expression ACE2,...
To evaluate the interference of hemoglobin variants J-Bangkok on glycated (HbA(1)c) detected by five measurement systems.Seventy cases blood samples were collected at Zhongshan Hospital Sun Yat-sen University from July 2012 to January 2014, divided into normal control group (40 cases) and Hb variant (30 cases), was healthy (20 diabetic cases). HbA(1)c systems Primus Ultra2, Variant Ⅱ, Ⅱ Turbo, Modular P Leadman. Based standard American National Glycosylated Hemoglobin Standardization Program...
Objective To evaluate the interference of hemoglobin variant E (HbE) on five kinds glycosylated (HbA1c) system. Two them were ion-exchange high performance liquid chromatography (IE-HPLC) methods, one was affinity (AC-HPLC) method, turbidimetric inhibition immunoassay method (TINIA), enzyme (EM) method. Methods All 60 blood samples from May 2012 to October 2013 collected Zhongshan Hospital Yat-sen University, and then divided into normal control group (20 cases), diabetic cases) HbE...