A5100401835- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Functional Brain Connectivity Studies
- Circular RNAs in diseases
- Protease and Inhibitor Mechanisms
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Alzheimer's disease research and treatments
- Bipolar Disorder and Treatment
- Visual perception and processing mechanisms
- Multisensory perception and integration
- S100 Proteins and Annexins
- Electrospun Nanofibers in Biomedical Applications
- Advanced Neuroimaging Techniques and Applications
- HER2/EGFR in Cancer Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- RNA regulation and disease
- Lung Cancer Treatments and Mutations
- Genetic Associations and Epidemiology
- Wound Healing and Treatments
- Signaling Pathways in Disease
- Advanced MRI Techniques and Applications
- Tissue Engineering and Regenerative Medicine
- Molecular Biology Techniques and Applications
Chongqing Technology and Business University
2025
Guangdong Medical College
2014-2024
Central Hospital of Wuhan
2024
Huashan Hospital
2024
Fudan University
2024
Huazhong University of Science and Technology
2024
Affiliated Hospital of Guangdong Medical College Hospital
2020-2023
Daping Hospital
2023
Army Medical University
2023
Jiangsu Hengrui Medicine (China)
2023
The motive forces for ciliary movement are generated by large multiprotein complexes referred to as outer dynein arms (ODAs), which preassembled in the cytoplasm prior transport axonemal compartment. In humans, defects structural components, docking complexes, or cytoplasmic assembly factors can cause primary dyskinesia (PCD), a disorder characterized chronic airway disease and laterality. By using combined high resolution copy-number variant mutation analysis, we identified ARMC4 mutations...
High-grade myopia (HM) is highly heritable, and has a high prevalence in the Han Chinese population. We carried out genome-wide association study involving 102 HM cases suffering from retinal degeneration, 335 controls who were free fundus diseases. Significant single-nucleotide polymorphisms replicated two follow-up studies: stage I involved 2628 independent 9485 controls, II further 263 586 HM-free controls. The results combined meta-analysis. Cases drawn A locus an intergenic region at...
MicroRNA-146a (miR-146a) acts as a pivotal regulatory molecule in immune response and various diseases, such carcinoma autoimmune diseases. Growing evidences have demonstrated the association of miR-146a gene single-nucleotide polymorphisms (SNPs) with risk several but no genetic relevance studies to sepsis been reported by now. Our study has analyzed two functional SNPs rs2910164 G/C rs57095329 A/G Chinese Han population (226 cases; 206 healthy controls). results indicated higher prevalence...
Background: miR-146a polymorphisms have been involved in susceptibility to multiple diseases. The aim of the present study was analyze potential association between two functional (rs2910164 and rs57095329) sclerosis (MS) Han Chinese population. Methods: A cohort 525 patients 568 healthy controls were genotyped detect by SNaPshot. Results: No significant differences detected distribution (P > 0.05). However, stratification gender showed a statistically difference frequency genotype...
Alzheimer's disease (AD) is neurodegenerative that occurs among the aging population and associated with impaired cognitive function. Amyloid-β (Aβ) oligomers initiate pathological cascade represent a neuropathic hallmark of AD. Th
miR146a is well known for its regulatory role in the immune response and inflammation. Recent studies have demonstrated links between Alzheimer disease (AD) suggested that may be involved neuroinflammation metabolism of amyloid-β (Aβ), which are critical events AD pathology. Although genetic focused on association gene susceptibility to several diseases, no study variability with has been conducted. In this report, we performed a case-control analyze genotype allele distributions miR146a,...
The study aimed to prepare a new type intra ocular lens (IOL), in which 5-Fu, as an antimetabolite drug, could be sustained released prevent posterior capsule opacification (PCO), and evaluate its efficacy safety vitro vivo.5-fluorouracil chitosan nanoparticles (5-Fu-CSNP) were prepared by template polymerization selected cell counting kit (CCK-8). 5-Fu-CSNPs that inhibit Human Lens Epithelial Cells (HLECs) proliferation most efficiently chosen for further analysis. We then investigated...
Although genetic variants of the A disintegrin and metalloproteinase 10 (ADAM10) gene have been shown to be associated with susceptibility several inflammatory-related diseases, date little is known about clinical relationship in development sepsis.Two promoter ADAM10 were selected analyze potential association risk sepsis. total 440 sepsis patients 450 matched healthy individuals two independent Chinese Han population enrolled. Pyrosequencing polymerase chain reaction-length polymorphism...
Background Globally, master’s and doctoral students, especially pregraduate are under great pressure. Probiotics emerging as a promising intervention to improve mental health via gut-brain axis. Objective The aim of this study was explore the impact Lacticaseibacillus paracasei K56 supplementation on perceived stress among students. Methods We conducted double-blind, randomized, placebo-controlled trial in 120 healthy students who faced graduation. Participants were randomly assigned either...
Context: Recent genome-wide association studies have revealed that common variations and rare copy-number contribute to the risk of mental disorders.Rare recurrent microdeletions at 1q21.1 were reported be associated with schizophrenia, BCL9 gene was also a functional candidate for disorders.Objectives: To investigate validate whether exist in variation region, and, if so, determine these confer schizophrenia or other disorders.Design: A 3-stage case-control study.Setting:
Summary Aim Dysregulation of the activity disintegrin/metalloproteinase ADAM 10 could contribute to development atherosclerosis. Although a number genetic studies have focused on association gene polymorphisms with susceptibility diseases, no variability atherosclerotic cerebral infarction ( ACI ) been conducted. The aim this study was analyze potential between promoter and . Methods associations rs653765 rs514049 possible risk were assessed among 347 patients 299 matched healthy individuals...
The RNA-Seq technology has revolutionized transcriptome characterization not only by accurately quantifying gene expression, but also the identification of novel transcripts like chimeric fusion transcripts. 'fusion' or 'chimeric' have improved diagnosis and prognosis several tumors, led to development therapeutic regimen. transcript detection is currently accomplished software packages, primarily relying on sequence alignment algorithms. sequencing reads from loci in cancer genomes can be...
In this study, a micropatterned scaffold with surface-loaded spherical bioactive glasses was successfully fabricated by the electrospinning technique and polydopamine (PDA) coating method for diabetic wound healing. The micro- to nanoscaled hierarchical structure PDA could mimic function of native extracellular matrix (ECM), sustainably release Si Ca ions. in vitro study revealed that adhesion, proliferation, migration, angiogenic differentiation human umbilical vein endothelial cells be...
Antibacterial hydrogel dressings play an important role in wound healing and infection treatment. The majority of hydrogels are obtained through chemical cross-linking complex synthesis or processing. Copper ions (Cu2+) have been involved sterilization; however, their direct use may lead to high local concentrations heavy metal toxic side effects. Herein, dopamine (DA) was polymerized situ along a polyvinyl alcohol (PVA) chain chelated copper form mixture. Ionic liquid (IL) choline-glycolate...
Cerebral small vessel disease (CSVD) closely correlates to cognitive impairment, but its pathophysiology and the neurovascular mechanisms of deficits were unclear. We aimed explore dysfunctional patterns coupling (NVC) in patients with CSVD further investigate CSVD-related impairment.
SARS-CoV-2 causes a spectrum of clinical symptoms from respiratory damage to gastrointestinal disorders. Intestinal infection triggers immune response. However, the cellular mechanism that how initiates and induces intestinal immunity is not understood. Here, we exploited SARS-CoV-2-GFP/ΔN trVLP pseudo-virus system demonstrated RIG-I DHX15 are required for sensing inducing response through MAVS signaling in epithelial cells (IECs) upon infection. NLRP6 also engages regulation by producing...
Background: Accumulating evidence suggests that the principal TNF-α converting enzyme, a disintegrin and metalloproteinase 17 (ADAM17), is involved in development of human abdominal aortic aneurysm (AAA). However, association between ADAM17 gene polymorphisms AAA has not been explored. The present study was aimed to determine promoter AAA. Methods: A total 316 patients with 306 age-matched healthy controls were enrolled this study. Two (rs12692386 rs1524668) determind. Real-time PCR employed...
The receptor for advanced glycation end products (RAGE) is a cell surface molecule of the immunoglobulin superfamily that binds diverse endogenous ligands involved in development chronic diseases and inflammatory damage. A growing body evidence has suggested RAGE progression obstructive pulmonary disease (COPD). present study investigated existence an association among three polymorphisms (-374T/A, -429T/C, G82S) gene with risk COPD Chinese population. genotypes were determined by polymerase...